US4742155A
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Plipastatin and method for preparation thereof
Assignee: Microbial Chemistry Research Foundation
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Filing: 1985-11-26
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Granted: 1988-05-03
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Expires: 2005-11-26
Abstract
Abstract Plipastatin represented by the general formula ##STR1## wherein R 1 is --C 13 H 27 or --C 14 H 29 ; and R 2 is Ala or Val, or salts thereof, which is prepared by culturing a Plipastatin-producing strain belonging to the genus Bacillus to produce and accumulate Plipastatin in a cultured broth and then isolating Plipastatin from the cultured broth. Plipastatin exhibits an enzyme inhibiting activity against phospholipase A 2 , C and D and which will be useful as an immunosuppressive agent or as a type I anti-allergic agent.
Inventors
- 👤 Hamao Umezawa
- 👤 Takaaki Aoyagi
- 👤 Tomio Takeuchi
- 👤 Masa Hamada
- 👤 Hiroshi Naganawa
- 👤 Yasuhiko Muraoka
- 👤 Takaaki Nishikiori
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:38
CPC Classifications
C; C12; C12P; C12P21/00; C12P21/02; C07; C07K; C07K7/00; C07K7/04; C07K7/06; A; A61; A61P; A61P37/00; A61P37/02; A61P37/06; A61P37/08; C12N; C12N1/00; C12N1/20; C12N1/205; A61K; A61K38/00; C12R; C12R2001/00; C12R2001/01; C12R2001/07; C12R2001/085; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/27
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
32 words
A compound of the following general formula: ##STR4## wherein R 1 is --C 13 H 27 or --C 14 H 29 ; and R 2 is Ala or Val, or salts thereof.
Claim 2
Dependent Claim
32 words
A compound of the following general formula: ##STR4## wherein R 1 is --C 13 H 27 or --C 14 H 29 ; and R 2 is Ala or Val, or salts thereof.
Claim 3
Dependent Claim
17 words
A compound according to claim 1, wherein R 1 is --C 13 H 27 or salts thereof.
Claim 4
Dependent Claim
17 words
A compound according to claim 1, wherein R 1 is --C 14 H 29 or salts thereof.
Claim 5
Dependent Claim
9 words
Plipastatin A 1 represented by the following formula ##STR5##
Claim 6
Dependent Claim
9 words
Plipastatin A 1 represented by the following formula ##STR5##
Claim 7
Dependent Claim
9 words
Plipastatin A 2 represented by the following formula ##STR6##
Claim 8
Dependent Claim
9 words
Plipastatin A 2 represented by the following formula ##STR6##
Claim 9
Dependent Claim
9 words
Plipastatin B 1 represented by the following formula ##STR7##
Claim 10
Dependent Claim
9 words
Plipastatin B 1 represented by the following formula ##STR7##
Claim 11
Dependent Claim
9 words
Plipastatin B 2 represented by the following formula ##STR8##
Claim 12
Dependent Claim
9 words
Plipastatin B 2 represented by the following formula ##STR8##
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-03 | 1991-11-02 | 1992-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-03 | 1995-11-02 | 1996-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-03 | 1999-11-02 | 2000-05-03 | $7700.00 | Window Closed / Lapsed |