US4753965A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating multiple sclerosis with chalcone derivatives
Assignee: Aventis Pharmaceuticals Inc
•
Filing: 1987-04-09
•
Granted: 1988-06-28
•
Expires: 2007-04-09
Abstract
Abstract Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are found to inhibit the destruction of the myelin sheath covering an axon of the central nervous system of a patient suffering from multiple sclerosis and are thus useful in the treatment of multiple sclerosis.
Inventors
- 👤 David M. Stemerick
- 👤 Sai P. Sunkara
- 👤 Michael L. Edwards
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 22:33
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/12; A61K31/13; A61K31/135
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
93 words
A method for inhibiting destruction of the myelin sheath covering an axon in the central nervous system of a patient suffering from multiple sclerosis which comprises administering to said patient suffering from said multiple sclerosis an effective amount of chalcone derivative of the structure ##STR4## wherein Ar is a 2,5-dimethoxyphenyl, 2,3,4-trimethoxyphenyl, or 3,4,5-trimethoxyphenyl group; R 1 is a hydrogen, (C 1 -C 4 )alkyl, chloro, or bromo group; and R 2 is a --N(R) 2 or --NH(O)R wherein R is a (C 1 -C 4 )alkyl group, or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
93 words
A method for inhibiting destruction of the myelin sheath covering an axon in the central nervous system of a patient suffering from multiple sclerosis which comprises administering to said patient suffering from said multiple sclerosis an effective amount of chalcone derivative of the structure ##STR4## wherein Ar is a 2,5-dimethoxyphenyl, 2,3,4-trimethoxyphenyl, or 3,4,5-trimethoxyphenyl group; R 1 is a hydrogen, (C 1 -C 4 )alkyl, chloro, or bromo group; and R 2 is a --N(R) 2 or --NH(O)R wherein R is a (C 1 -C 4 )alkyl group, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
16 words
A method of claim 1 wherein R 1 is a (C 1 -C 4 ) group.
Claim 4
Dependent Claim
12 words
A method of claim 1 wherein R 1 is a methyl group.
Claim 5
Dependent Claim
16 words
A method of claim 1, 2, or 3 wherein R 2 is a --N(R) 2 .
Claim 6
Dependent Claim
11 words
A method of claim 4 wherein R is a methyl group.
Claim 7
Independent Claim
14 words
A method of any of the preceding claims wherein Ar is a 2,5-dimethoxyphenyl group.
Claim 8
Dependent Claim
24 words
A method of claim 1 wherein R 1 is a methyl group, R 2 is a dimethylamino group, and Ar is a 2,5-dimethoxyphenyl group.
Claim 9
Independent Claim
79 words
A method of treating a human suffering from multiple sclerosis which comprises administering to said human suffering from multiple sclerosis an effective amount of a chalcone derivative of the structure ##STR5## wherein Ar is a 2,5-dimethoxyphenyl, 2,3,4-trimethoxyphenyl, or 3,4,5-trimethoxyphenyl group; R 1 is a hydrogen, (C 1 -C 4 )alkyl, chloro, or bromo group; and R 2 is a --N(R) 2 or --NH(O)R wherein R is a (C 1 -C 4 )alkyl group, or a pharmaceutically acceptable salt thereof.
Claim 10
Independent Claim
79 words
A method of treating a human suffering from multiple sclerosis which comprises administering to said human suffering from multiple sclerosis an effective amount of a chalcone derivative of the structure ##STR5## wherein Ar is a 2,5-dimethoxyphenyl, 2,3,4-trimethoxyphenyl, or 3,4,5-trimethoxyphenyl group; R 1 is a hydrogen, (C 1 -C 4 )alkyl, chloro, or bromo group; and R 2 is a --N(R) 2 or --NH(O)R wherein R is a (C 1 -C 4 )alkyl group, or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
16 words
A method of claim 8 wherein R 1 is a (C 1 -C 4 ) group.
Claim 12
Dependent Claim
12 words
A method of claim 8 wherein R 1 is a methyl group.
Claim 13
Dependent Claim
16 words
A method of claim 8, 9, or 10 wherein R 2 is a --N(R) 2 .
Claim 14
Dependent Claim
11 words
A method of claim 11 wherein R is a methyl group.
Claim 15
Independent Claim
14 words
A method of any of the preceding claims wherein Ar is a 2,5-dimethoxyphenyl group.
Claim 16
Dependent Claim
24 words
A method of claim 8 wherein R 1 is a methyl group, R 2 is a dimethylamino group, and Ar is a 2,5-dimethoxyphenyl group.
References Cited (Backward Citations)
GB943266A
Cited
US3729313A
Cited
US3808006A
Cited
DE2558813A1
Cited
US4054682A
Cited
US4367280A
Cited
US4162162A
Cited
US4290870A
Cited
US4279930A
Cited
EP0013960A1
Cited
EP0028305A1
Cited
GB2081716A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-28 | 1991-12-28 | 1992-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-28 | 1995-12-28 | 1996-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-28 | 1999-12-28 | 2000-06-28 | $7700.00 | Window Closed / Lapsed |