Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents
Abstract
Abstract There are disclosed compounds of the formula ##STR1## wherein W represents a covalent bond or ##STR2## X is N or CR 2 ; Y is O, S, NR 2 or C(R 2 ) 2 when n=0, or N or CR 2 when n=1 Z is ##STR3## R 1 is hydrogen, lower alkyl, trifluoromethyl, nitro, hydroxy, lower alkoxy, mercapto, loweralkylthio or halo; R 2 is hydrogen or lower alkyl; n is 0-1; m is 1-6 with the proviso that m is 0-5 when W represents a covalent bond; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.
Inventors
- 👤 John H. Musser
- 👤 Dennis M. Kubrak
Bibliographic Details
Claims Analysis
Total Claims: 8References Cited (Backward Citations)
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