US4809701A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method to measure the molecular diffusion and/or perfusion parameters of live tissue
Assignee: General Electric CGR SA
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Filing: 1987-09-23
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Granted: 1989-03-07
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Expires: 2007-09-23
Abstract
Abstract By synchronizing the radio-frequency excitations of a nuclear magnetic resonance experiment with the heart beat of a patient, notable improvement is obtained in the measurement of the molecular diffusion parameters of the tissues studied. In particular, good images of the brain are obtained in this way: the parameter represented is the molecular diffusion constant.
Inventors
- 👤 Denis Le Bihan
- 👤 Eric Breton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:08
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/567; G01R33/5673; G01R33/563; G01R33/56341
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
71 words
A method to measure the molecular diffusion parameters of a live and resting tissue of a patient using an NMR experiment, comprising at least one series of radio-frequency excitation sequences of said tissue, each sequence being followed by measurements of a NMR signal resulting from said excitations, said NMR signals being then processed for giving said molecular diffusion parameters, wherein the excitations are synchronized with the cardiac rhythm of the patient.
Claim 2
Independent Claim
71 words
A method to measure the molecular diffusion parameters of a live and resting tissue of a patient using an NMR experiment, comprising at least one series of radio-frequency excitation sequences of said tissue, each sequence being followed by measurements of a NMR signal resulting from said excitations, said NMR signals being then processed for giving said molecular diffusion parameters, wherein the excitations are synchronized with the cardiac rhythm of the patient.
Claim 3
Dependent Claim
16 words
A method according to the claim 1, wherein the measurement comprises an imaging of the parameters.
Claim 4
Dependent Claim
17 words
A method according to the claim 1, wherein one of the parameters is the molecular diffusion constant.
Claim 5
Dependent Claim
17 words
A method according to the claim 1, wherein the tissue is the tissue of the patient's brain.
Claim 6
Dependent Claim
20 words
A method according to the claim 1, wherein the excitations are synchronized with selected instants of the patient's heart rhythm.
Claim 7
Dependent Claim
61 words
A method according to the claim 1 wherein, at the end of a first and second series of excitation sequences, a first image and second image are acquired, a characteristic of the experiment being modified during the second series of the excitation sequence, the molecular diffusion parameters being deduced in a third image of point-to-point comparisons of the first two images.
Claim 8
Independent Claim
69 words
A method to measure the perfusion parameters of a live and resting tissue of a patient using an NMR experiment, comprising at least one series of radio-frequency excitation sequences of said tissue, each sequence being followed by measurements of a NMR signal resulting from said excitations, said NMR signals being then processed for giving said perfusion parameters, wherein the excitations are synchronized with the heart beat of the patient.
Claim 9
Independent Claim
69 words
A method to measure the perfusion parameters of a live and resting tissue of a patient using an NMR experiment, comprising at least one series of radio-frequency excitation sequences of said tissue, each sequence being followed by measurements of a NMR signal resulting from said excitations, said NMR signals being then processed for giving said perfusion parameters, wherein the excitations are synchronized with the heart beat of the patient.
Claim 10
Independent Claim
71 words
A method to measure the molecular diffusion and perfusion parameters of a live and resting tissue of a patient using an NMR experiment, comprising at least one series of radio-frequency excitation sequences of said tissue, each sequence being followed by measurements of a NMR signal resulting from said excitations, said NMR signals being then processed for giving said parameters, wherein the excitations are synchronized with the heart beat of the patient.
Claim 11
Independent Claim
71 words
A method to measure the molecular diffusion and perfusion parameters of a live and resting tissue of a patient using an NMR experiment, comprising at least one series of radio-frequency excitation sequences of said tissue, each sequence being followed by measurements of a NMR signal resulting from said excitations, said NMR signals being then processed for giving said parameters, wherein the excitations are synchronized with the heart beat of the patient.
References Cited (Backward Citations)
US4424487A
Cited
US4413233A
Cited
EP0132975A2
Cited
EP0132785A2
Cited
US4595879A
Cited
US4712560A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-06 | 1992-09-05 | 1993-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-06 | 1996-09-05 | 1997-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-06 | 2000-09-05 | 2001-03-07 | $7700.00 | Window Closed / Lapsed |