US4814342A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nor-statine and nor-cyclostatine polypeptides
Assignee: Pfizer Inc
•
Filing: 1987-10-23
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Granted: 1989-03-21
•
Expires: 2007-10-23
Abstract
Abstract Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
Inventors
- 👤 Dennis J. Hoover
- 👤 Robert L. Rosati
- 👤 Ronald T. Wester
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:12
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/0202; C07K5/04; C07K5/06; C07K5/06008; C07K5/06078; C07K5/06139; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/86
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
91 words
A compound of the formula ##STR5## and a pharmaceutically acceptable salt thereof, wherein Z is R 1 -(Y) m -(A) p , where R 1 is morpholino; Y is C=O; A is NH; m and p are each 1; M is phenyl; Q is hydrogen; R 2 is alkyl or C 1 -C 3 alkylthioalkyl; X is cyclohexyl; X is CH OH; Z 1 is R-S-T where R is C═O, S is O, NH, N(CH 3 ), CH 2 or a chemical bond linking R and T; and T is alkyl.
Claim 2
Dependent Claim
91 words
A compound of the formula ##STR5## and a pharmaceutically acceptable salt thereof, wherein Z is R 1 -(Y) m -(A) p , where R 1 is morpholino; Y is C=O; A is NH; m and p are each 1; M is phenyl; Q is hydrogen; R 2 is alkyl or C 1 -C 3 alkylthioalkyl; X is cyclohexyl; X is CH OH; Z 1 is R-S-T where R is C═O, S is O, NH, N(CH 3 ), CH 2 or a chemical bond linking R and T; and T is alkyl.
Claim 3
Dependent Claim
35 words
A compound of claim 1, wherein Y is C═O, A is NH, Q is hydrogen, X is cyclohexyl, W is CH OH, R is C═O, T is alkyl and m and p are each 1.
Claim 4
Dependent Claim
24 words
The compound of claim 2, wherein R 1 is morpholino, M is phenyl, R 2 is n-propyl, S is O and T is i-propyl.
Claim 5
Dependent Claim
28 words
The compound of claim 2, wherein R 1 is morpholino, M is phenyl, R 2 is CH 3 SCH 2 --, S is O and T is i-propyl.
Claim 6
Dependent Claim
24 words
The compound of claim 2, wherein R 1 is morpholino, M is phenyl, R 2 is n-butyl, S is O and T is methyl.
Claim 7
Dependent Claim
36 words
The compound of claim 2, wherein R 1 is morpholino, M is phenyl, R 2 is n-butyl, S is a chemical bond linking R and T and T is CH 2 CH(CH 3 ) 2 .
Claim 8
Dependent Claim
40 words
The compound of claim 2, wherein R 1 is morpholino, M is phenyl, R 2 is CH 3 SCH 2 --, S is a chemical bond linking R and T and T is --CH 2 CH(CH 3 ) 2 .
Claim 9
Dependent Claim
24 words
The compound of claim 2, wherein R 1 is morpholino, M is phenyl, R 2 is methyl, S is O and T is i-propyl.
Claim 10
Dependent Claim
24 words
The compound of claim 2, wherein R 1 is morpholino, M is phenyl, R 2 is n-butyul, S is O and T is i-propyl.
Claim 11
Dependent Claim
31 words
A compound of claim 1, formula I, wherein M is phenyl, S is a chemical bond linking R and T, T is (C 1 -C 5 )alkyl and R is C═O.
Claim 12
Dependent Claim
25 words
A method of treating hypertension in a mammal which comprises administering to said mammal an antihypertensive effective amount of a compound according to claim 1.
Claim 13
Dependent Claim
22 words
A pharmaceutical composition comprising an antihypertensive effective amount of a compound according to claim 1 and a pharmaceutically acceptable diluent or carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-20 | 1992-09-19 | 1993-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-20 | 1996-09-19 | 1997-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-20 | 2000-09-19 | 2001-03-21 | $7700.00 | Window Closed / Lapsed |