Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity

Claim 1

A compound having the formula (II) ##STR56## and the nontoxic, pharmaceutically acceptable base or acid addition salts thereof, wherein is a single or double bond; (1) one of R a is present and is (a) hydrogen (b) alkyl of from one to twenty carbons, inclusive, (c) ##STR57## wherein y is zero, one, two, three, four, or five and R' is cycloalkyl of from four to twenty carbons, inclusive in a one, two or three saturated ring system, said ring comprising from four to eight carbons inclusive, each ring unsubstituted or substituted by a straight or branched lower alkyl group, naphthyl, heteroaryl, phenyl unsubstituted or substituted with of from one through five substituents selected from the group consisting of lower alkyl, halo, trifluoroemthyl, hydroxy, lower alkoxy, lower alkyl acyloxy, amino, N-lower monalkylamino, N,N-lower dialkylamino, lower thioalkyl, lower alkylsulfonyl, nitro and ##STR58## wherein R 10 is lower alkyl, phenyl unsubtituted or substituted by lower alkyl, or --NHR 11 wherein R 11 is hydrogen or lower alkyl, and R" is hydrogen, lower alkyl, cycloalkyl of from four to twenty carbons, inclusive in a one, two or three saturated ring system, said ring comprising from four to eight carbons inclusive, each ring unsubstituted or substituted by a straight or branched lower alkyl group, naphthayl, phenyl unsubstituted or substituted with of from one through five substituents selected from the group consisting of alkyl, halo, trifluoromethyl, amino, N-lower monalkylamino, N,N-lower dialkylamino, lower thioalkyl, lower alkylsulfonyl, and nitro; (2) Z is oxygen or sulfur; and (3) R 2 is (a) hydrogen (b) halo, (c) lower alkyl, (d) R'--CH 2 -- x wherein x is one, two, three, four, or five, and R' is independently as defined above, (e) ##STR59## wherein R' is independently as defined above, or (f) R'--CH(OH)-- wherein R' is independently as defined above; (4) R is selected from the group consisting of lower alkyl, heteroaryl, and phenyl or benzyl each unsubstituted or substituted with of from one through five substituents selected from the group consisting of lower alkyl, halo, trifluoromethyl, hyroxy, lower alkoxy, lower alkyl acyloxy, amino, N-lower monoalkylamino, N,N-lower dialkylamino, lower thioalkyl, lower alkylsulfonyl, and nitro; wherein the heteroaryl is 2-, 3-, or 4-pyridyl; 1-, 2-, or 4-imidazolyl; 1-, 2-, 3-, 4-, 5-, 6- or 7-indolyl; 2-, or 3-thienyl, 2-, or 3-furyl; of 1-, 2-, or 3-pyrazolyl.