US4820490A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device and method for chemical analysis of fluids with a reagent coated light source
Assignee: Bayer Corp
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Filing: 1987-07-20
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Granted: 1989-04-11
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Expires: 2007-07-20
Abstract
Abstract A device for measuring transmittance of light comprises a light source, photodetector and signal processor. The concentration of a substance in a fluid sample can be accurately determined by coating the light source with a reagent that is chemically reactive with the substance and measuring light transmitted from the coating before and after the substance is applied to the coating. The coating can contain a solid support matrix, such as a translucent nonwoven paper web of the type used in reagent test strips and similar indicator devices. The invention is useful for making clinical analyses on body fluids.
Inventors
- 👤 David A. N. Morris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:01
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/17; G01N21/25; G01N21/255; Y; Y10; Y10S; Y10S436/00; Y10S436/805
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
67 words
A light-emitting diode consisting of a light-emitting diode end surface through which light from the diode can pass; a liquid permeable, light-transmitting coating on the end surface of the diode; a reagent composition for a ligand from a body fluid, wherein the reagent composition is contained in the coating and is chemically reactive with the ligand to produce a change in transmittance of light by the coating.
Claim 2
Dependent Claim
67 words
A light-emitting diode consisting of a light-emitting diode end surface through which light from the diode can pass; a liquid permeable, light-transmitting coating on the end surface of the diode; a reagent composition for a ligand from a body fluid, wherein the reagent composition is contained in the coating and is chemically reactive with the ligand to produce a change in transmittance of light by the coating.
Claim 3
Dependent Claim
16 words
Light-emitting diode according to claim 1, wherein said end surface of the diode is substantially flat.
Claim 4
Dependent Claim
13 words
Light-emitting diode according to claim 1, wherein the coating also contains the ligand.
Claim 5
Dependent Claim
20 words
Light-emitting diode according to claim 1, wherein the coating contains the product of the reaction of ligand and reagent composition.
Claim 6
Dependent Claim
20 words
Light-emitting diode according to claim 1, wherein the reagent in the coating comprises glucose oxidase, peroxidase and a color indicator.
Claim 7
Dependent Claim
11 words
Light-emitting diode according to claim 5, wherein the indicator is tetramethylbenzidine.
Claim 8
Dependent Claim
19 words
Light-emitting diode according to claim 6, wherein the coating contains a solid, transparent or translucent, liquid permeable support matrix.
Claim 9
Independent Claim
146 words
A method for determining the presence or concentration of a ligand in a specimen by measuring transmission of light in a device comprising light source means for illuminating the specimen and means for measuring light from the specimen, wherein the method comprises providing a transparent or translucent coating on an end surface of the light source through which light from the light source passes, wherein the coating contains a reagent that displays chemical reactivity with a ligand by a change in optical characteristics; measuring light from the light source transmitted from the coating to said measuring means; applying a liquid specimen containing the ligand onto the coating; allowing sufficient time to react substantially all of the ligand in the liquid specimen to form an optically discernible product; and measuring light from the light source transmitted from the coating containing the reaction product to said measuring means.
Claim 10
Independent Claim
146 words
A method for determining the presence or concentration of a ligand in a specimen by measuring transmission of light in a device comprising light source means for illuminating the specimen and means for measuring light from the specimen, wherein the method comprises providing a transparent or translucent coating on an end surface of the light source through which light from the light source passes, wherein the coating contains a reagent that displays chemical reactivity with a ligand by a change in optical characteristics; measuring light from the light source transmitted from the coating to said measuring means; applying a liquid specimen containing the ligand onto the coating; allowing sufficient time to react substantially all of the ligand in the liquid specimen to form an optically discernible product; and measuring light from the light source transmitted from the coating containing the reaction product to said measuring means.
Claim 11
Dependent Claim
18 words
Method according to claim 8, wherein the coating contains a solid, transparent or translucent, liquid permeable, support matrix.
Claim 12
Dependent Claim
15 words
Method according to claim 9, wherein the support matrix is a translucent nonwoven paper web.
Claim 13
Dependent Claim
19 words
Method according to claim 10, wherein the reagent in the coating comprises glucose oxidase, peroxidase and a color indicator.
Claim 14
Dependent Claim
10 words
Method according to claim 11, wherein the indicator is tetramethylbenzidine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-10 | 1992-10-10 | 1993-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-10 | 1996-10-10 | 1997-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-10 | 2000-10-10 | 2001-04-11 | $7700.00 | Window Closed / Lapsed |