Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents

Claim 1

A method for treating cerebrovascular disorders which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula ##STR12## or a pharmaceutically acceptable salt thereof in unit dosage form wherein R 1 and R 2 are the same or different and are hydrogen, straight or branched alkyl of from one to six carbon atoms, lower alkylaryl, lower alkenyl, phenyl, CF 3 , hydroxy, lower alkoxy, lower alkylthio, lower alkylsulphonyl, CF 3 O at the six position, halogen, nitro, carboxy, lower alkoxycarbonyl, NR 5 R 6 CO, NR 5 R 6 , R 5 CONR 5 , CN, NR 5 R 6 SO 2 , wherein R 5 and R 6 may be the same or different and are hydrogen, lower alkyl, or aryl; R 1 and R 2 may together form a carbocyclic or methylenedioxy ring; R 3 is hydrogen; R 4 is hydrogen, lower alkyl, methylcycloalkyl, benzyl, phenethyl, phenyl, substituted phenyl, alkyl, propargyl with the proviso that R 1 , R 2 , and R 3 must be hydrogen when R 4 is not hydrogen.

Claim 2

A method for treating cerebrovascular disorders which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula ##STR12## or a pharmaceutically acceptable salt thereof in unit dosage form wherein R 1 and R 2 are the same or different and are hydrogen, straight or branched alkyl of from one to six carbon atoms, lower alkylaryl, lower alkenyl, phenyl, CF 3 , hydroxy, lower alkoxy, lower alkylthio, lower alkylsulphonyl, CF 3 O at the six position, halogen, nitro, carboxy, lower alkoxycarbonyl, NR 5 R 6 CO, NR 5 R 6 , R 5 CONR 5 , CN, NR 5 R 6 SO 2 , wherein R 5 and R 6 may be the same or different and are hydrogen, lower alkyl, or aryl; R 1 and R 2 may together form a carbocyclic or methylenedioxy ring; R 3 is hydrogen; R 4 is hydrogen, lower alkyl, methylcycloalkyl, benzyl, phenethyl, phenyl, substituted phenyl, alkyl, propargyl with the proviso that R 1 , R 2 , and R 3 must be hydrogen when R 4 is not hydrogen.