US4833125A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of increasing bone mass
Assignee: General Hospital Corp
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Filing: 1987-05-21
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Granted: 1989-05-23
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Expires: 2007-05-21
Abstract
Abstract A method for increasing bone mass in a human afflicted with osteoporosis or a similar disease which comprises administering to the human so afflicated an effective amount of a composition comprising a parathyroid hormone or physiologically active fragment thereof, or equivalents thereof, in combination with either (a) a hydroxylated Vitamin D compound, or a structural or functional analogue thereof, or (b) a dietary calcium supplement. Pharmaceutical compositions containing the necessary components are also disclosed.
Inventors
- 👤 Robert M. Neer
- 👤 John T. Potts, Jr.
- 👤 David M. Slovik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 06:46
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/29
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
96 words
A kit useful for administering a bone mass increasing composition comprising a carrier being compartmentalized to receive in close confinement therein one or more containers wherein: (a) a first container or series of containers contain parathyoid hormone or a physiologically active fragment thereof; said hormone or said fragment obtainable from a human, or other animal; (b) a second container contains an agent selected from the group consisting of: (i) a hydroxylated Vitamin D compound, and (ii) a dietary calcium supplement, and (c) a third container contains a buffer for reconstituting or diluting components of said kit.
Claim 2
Dependent Claim
96 words
A kit useful for administering a bone mass increasing composition comprising a carrier being compartmentalized to receive in close confinement therein one or more containers wherein: (a) a first container or series of containers contain parathyoid hormone or a physiologically active fragment thereof; said hormone or said fragment obtainable from a human, or other animal; (b) a second container contains an agent selected from the group consisting of: (i) a hydroxylated Vitamin D compound, and (ii) a dietary calcium supplement, and (c) a third container contains a buffer for reconstituting or diluting components of said kit.
Claim 3
Dependent Claim
19 words
The kit of claim 1 wherein said kit contains means for administering said first agent and said second agent.
Claim 4
Dependent Claim
16 words
The kit of claim 1 wherein said first container contains a peptide fragment of parathyroid hormone.
Claim 5
Dependent Claim
24 words
The kit of claim 3 wherein said peptide fragment consists of the first 34 amino acid residues from the amino terminal of parathyroid hormone.
Claim 6
Dependent Claim
15 words
The kit of claim 1 wherein said synergistic agent is a hydroxylated Vitamin, D compound.
Claim 7
Dependent Claim
12 words
The kit of claim 5 wherein said compound is 1-hydroxy Vitamin D.
Claim 8
Dependent Claim
13 words
The kit of claim 5 wherein said compound is 1, 25-dihydroxy Vitamin D.
Claim 9
Dependent Claim
14 words
The kit of claim 1 wherein said synergistic agent is a dietary calcium supplement.
References Cited (Backward Citations)
US4698328A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-22 | 1992-11-21 | 1993-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-22 | 1996-11-21 | 1997-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-22 | 2000-11-21 | 2001-05-23 | $7700.00 | Window Closed / Lapsed |