US4859606A
Expired / Lapsed
US
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Method for detecting cations in a test sample utilizing chromogenic cryptahemispherands
Assignee: Bayer Corp
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Filing: 1987-04-15
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Granted: 1989-08-22
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Expires: 2007-04-15
Abstract
Abstract The present invention resides in the discovery of a class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation; a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4. A test device utilizing one or more of the compounds for performing such measurements is also disclosed.
Inventors
- 👤 Donald J. Cram
- 👤 Eddy Chapoteau
- 👤 Bronislaw P. Czech
- 👤 Carl R. Gebauer
- 👤 Roger C. Helgeson
- 👤 Anand Kumar
- 👤 Koon-Wah Leong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:16
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/02; C07D498/08; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/84
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
146 words
A method for selectively determining the presence of a test cation in a test sample, comprising the steps of: (a) contacting said test sample with a compound which complexes selectively to the test cation and being of the formula: ##STR7## wherein: R, the same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R', the same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R", the same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or unsubstituted aryl; Q is a chromogenic moiety capable of providing a detectable response upon the complexation of said compound with said test cation; a, b, m and n, the same or different, are 1 to 3; x is 1 to 4; and y is 1 to 4; and y is 1 to 4; and (b) measuring said detectable response.
Claim 2
Independent Claim
146 words
A method for selectively determining the presence of a test cation in a test sample, comprising the steps of: (a) contacting said test sample with a compound which complexes selectively to the test cation and being of the formula: ##STR7## wherein: R, the same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R', the same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; R", the same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or unsubstituted aryl; Q is a chromogenic moiety capable of providing a detectable response upon the complexation of said compound with said test cation; a, b, m and n, the same or different, are 1 to 3; x is 1 to 4; and y is 1 to 4; and y is 1 to 4; and (b) measuring said detectable response.
Claim 3
Dependent Claim
29 words
The method of claim 1 wherein said chromogenic moiety Q of said compound has the structure: ##STR8## wherein G is 2,4,6e-trinitroanilino; 2,6-dinitro-4-trifluoromethylanilino; 2,4-dinitro-6-trifluoromethylanilino; 4-nitro-anilino; 2,4-dinitrophenylazo; 4-nitrophenylazo; 4-nitrostyryl; and 4-benzoquinonmonoimino.
Claim 4
Dependent Claim
53 words
The method of claim 2 wherein when R is not hydrogen, said chromogenic moiety Q has the structure: ##STR9## wherein: Y, the same or different, is an electron withdrawing group such as CN, NO 2 , CF 3 or COOR wherein R is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl.
Claim 5
Dependent Claim
13 words
The method of claim 3, wherein G is 2,4,6-trinitroanilino, 2,6-dinitro-4-trifluoromethylanilino, 2,4-dinitro-6-trifluoromethylanilino or 4-nitroanilino.
Claim 6
Independent Claim
41 words
The method of claims 1 to 4 wherein said compound is incorporated into a solid carrier member with a buffer capable of providing a pH in the range of about 5-9, and contacting said test sample with said solid carrier member.
Claim 7
Dependent Claim
64 words
A test device for determining the presence of a test cation in an aqueous test sample pursuant to the method of one of claims 1-4, said device comprising a solid carrier member, the compound of one of claims 1-4 incorporated into said solid carrier member and a buffer incorporated into said carrier member capable of providing a pH in the range of about 5-9.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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