US4863736A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Somatotropin prolonged release
Assignee: Monsanto Technology LLC
•
Filing: 1988-02-03
•
Granted: 1989-09-05
•
Expires: 2008-02-03
Abstract
Abstract Provided is a shaped article adapted for parenteral implantation, to obtain prolonged administration of a somatotropin to an animal comprising an effective dose of a solid somatotropin, which is essentially binder-free, essentially matrix-free and has at least one uncoated release surface.
Inventors
- 👤 Michael J. Azain
- 👤 Kenneth E. Eigenberg
- 👤 Thomas R. Kasser
- 👤 M. Jerome Sabacky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 05:43
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61P; A61P15/00
Claims Analysis
Total Claims: 55
Claim 1
Independent Claim
42 words
A shaped article adapted for parenteral administration of a somatotropin to an animal, comprising an effective dose of a solid somatotropin and an effective amount of a lubricant, which is essentially binder-free, essentially matrix-free, and has at least one uncoated release surface.
Claim 2
Dependent Claim
42 words
A shaped article adapted for parenteral administration of a somatotropin to an animal, comprising an effective dose of a solid somatotropin and an effective amount of a lubricant, which is essentially binder-free, essentially matrix-free, and has at least one uncoated release surface.
Claim 3
Dependent Claim
14 words
The article of claim 1 in which the somatotropin is a microbially expressed somatotropin.
Claim 4
Dependent Claim
21 words
The article of claim 1 in which the somatotropin is selected from the group consisting of bovine somatotropin and porcine somatotropin.
Claim 5
Dependent Claim
14 words
The article of claim 3 in which the somatotropin is microbially expressed bovine somatotropin.
Claim 6
Dependent Claim
14 words
The article of claim 4 in which the microbially expressed bovine somatotropin is MBS.
Claim 7
Dependent Claim
15 words
The article of claim 4 in which the microbially expressed bovine somatotropin is ala-val BST.
Claim 8
Dependent Claim
14 words
The article of claim 3 in which the somatotropin is microbially expressed porcine somatotropin.
Claim 9
Dependent Claim
14 words
The article of claim 7 in which the microbially expressed porcine somatotropin is APS.
Claim 10
Dependent Claim
28 words
The article of claim 7 in which the microbially expressed porcine somatotropin is copper-associated porcine somatotropin or a dry blend of a copper salt and a porcine somatotropin.
Claim 11
Dependent Claim
16 words
The article of claim 9 which has a copper content from about 0.1% to about 3%.
Claim 12
Dependent Claim
57 words
A shaped article adapted for parenteral administration of a somatotropin to an animal, comprising a. an effective dose of a solid somatotropin, selected from the group consisting of microbially expressed bovine and porcine somatotropin; b. an effective amount of a lubricant; and c. which is essentially binder-free, essentially matrix-free, and has at least one uncoated release surface.
Claim 13
Dependent Claim
57 words
A shaped article adapted for parenteral administration of a somatotropin to an animal, comprising a. an effective dose of a solid somatotropin, selected from the group consisting of microbially expressed bovine and porcine somatotropin; b. an effective amount of a lubricant; and c. which is essentially binder-free, essentially matrix-free, and has at least one uncoated release surface.
Claim 14
Dependent Claim
19 words
The article of claim 11 in which the lubricant is selected from the group consisting of stearates and palmitates.
Claim 15
Dependent Claim
14 words
The article of claim 11 in which the microbially expressed somatotropin is bovine somatotropin.
Claim 16
Dependent Claim
14 words
The article of claim 13 in which the microbially expressed bovine somatotropin is MBS.
Claim 17
Dependent Claim
15 words
The article of claim 13 in which the microbially expressed bovine somatotropin is ala-val BST.
Claim 18
Dependent Claim
15 words
The article of claim 11 in which the microbially expressed somatotropin is a porcine somatotropin.
Claim 19
Dependent Claim
14 words
The article of claim 16 in which the microbially expressed porcine somatotropin is APS.
Claim 20
Dependent Claim
29 words
The article of claim 16 in which the microbially expressed porcine somatotropin is a copper-associated porcine somatotropin or a dry blend of a copper salt and a porcine somatotropin.
Claim 21
Dependent Claim
63 words
A shaped article adapted for parenteral administration of a somatotropin to an animal, consisting essentially of: a. an effective dose of a solid somatotropin; b. an effective amount of a lubricant; and c. optionally, a coating on one or more surfaces of the article, which substantially inhibits release of the somatotropin from the coated surfaces, but with at least one uncoated release surface.
Claim 22
Dependent Claim
63 words
A shaped article adapted for parenteral administration of a somatotropin to an animal, consisting essentially of: a. an effective dose of a solid somatotropin; b. an effective amount of a lubricant; and c. optionally, a coating on one or more surfaces of the article, which substantially inhibits release of the somatotropin from the coated surfaces, but with at least one uncoated release surface.
Claim 23
Dependent Claim
14 words
The article of claim 19 in which the somatotropin is a microbially expressed somatotropin.
Claim 24
Dependent Claim
21 words
The article of claim 19 in which the somatotropin is selected from the group consisting of bovine somatotropin and porcine somatotropin.
Claim 25
Dependent Claim
14 words
The article of claim 19 in which the somatotropin is microbially expressed bovine somatotropin.
Claim 26
Dependent Claim
14 words
The article of claim 22 in which the microbially expressed bovine somatotropin is MBS.
Claim 27
Dependent Claim
15 words
The article of claim 24 in which the microbially expressed bovine somatotropin is ala-val BST.
Claim 28
Dependent Claim
14 words
The article of claim 21 in which the somatotropin is microbially expressed porcine somatotropin.
Claim 29
Dependent Claim
14 words
The article of claim 25 in which the microbially expressed porcine somatotropin is APS.
Claim 30
Dependent Claim
28 words
The article of claim 25 in which the microbially expressed porcine somatotropin is copper-associated porcine somatotropin or a dry blend of a copper salt and a porcine somatotropin.
Claim 31
Dependent Claim
16 words
The article of claim 27 which has a copper content from about 0.1% to about 3%.
Claim 32
Independent Claim
40 words
A method of prolonged administration of a somatotropin to an animal, comprising parenteral implantation of a shaped article comprising an effective dose of a solid somatotropin, which is essentially binder-free, essentially matrix-free and has at least one uncoated release surface.
Claim 33
Independent Claim
40 words
A method of prolonged administration of a somatotropin to an animal, comprising parenteral implantation of a shaped article comprising an effective dose of a solid somatotropin, which is essentially binder-free, essentially matrix-free and has at least one uncoated release surface.
Claim 34
Dependent Claim
13 words
The method of claim 29 wherein the somatotropin is a microbially expressed somatotropin.
Claim 35
Dependent Claim
13 words
The method of claim 30 wherein the microbially expressed somatotropin is bovine somatotropin.
Claim 36
Dependent Claim
11 words
The method of claim 31 wherein the bovine somatotropin is MBS.
Claim 37
Dependent Claim
15 words
The method of claim 31 in which the microbially expressed bovine somatotropin is ala-val BST.
Claim 38
Dependent Claim
13 words
The method of claim 30 wherein the microbially expressed somatotropin is porcine somatotropin.
Claim 39
Dependent Claim
14 words
The method of claim 34 in which the microbially expressed porcine somatotropin is APS.
Claim 40
Dependent Claim
25 words
The method of claim 35 wherein the porcine somatotropin is copper-associated porcine somatotropin or a dry blend of a copper salt and a porcine somatotropin.
Claim 41
Dependent Claim
19 words
The method of claim 36 wherein the shaped article has a copper content from about 0.1% to about 3%.
Claim 42
Independent Claim
86 words
A method of prolonged administration of a somatotropin to an animal comprising parenteral implantation of a shaped article comprising: a. an effective dose of a solid somatotropin selected from the group consisting of microbially expressed bovine and porcine somatotropin; b. optionally an effective amount of a lubricant; c. optionally a coating on one or more surfaces of the article, which substantially inhibits release of the somatotropin from the coated surfaces; and d. which is essentially binder-free, essentially matrix-free and has at least one uncoated release surface.
Claim 43
Independent Claim
86 words
A method of prolonged administration of a somatotropin to an animal comprising parenteral implantation of a shaped article comprising: a. an effective dose of a solid somatotropin selected from the group consisting of microbially expressed bovine and porcine somatotropin; b. optionally an effective amount of a lubricant; c. optionally a coating on one or more surfaces of the article, which substantially inhibits release of the somatotropin from the coated surfaces; and d. which is essentially binder-free, essentially matrix-free and has at least one uncoated release surface.
Claim 44
Independent Claim
69 words
A method of prolonged administration of a somatotropin to an animal, comprising parenteral implantation of a shaped article consisting essentially of: a. an effective dose of a solid somatotropin; b. optionally, an effective amount of a lubricant; and c. optionally, a coating on one or more surfaces of the article, which substantially inhibits release of the somatotropin from the coated surfaces, but with at least one uncoated release surface.
Claim 45
Independent Claim
69 words
A method of prolonged administration of a somatotropin to an animal, comprising parenteral implantation of a shaped article consisting essentially of: a. an effective dose of a solid somatotropin; b. optionally, an effective amount of a lubricant; and c. optionally, a coating on one or more surfaces of the article, which substantially inhibits release of the somatotropin from the coated surfaces, but with at least one uncoated release surface.
Claim 46
Dependent Claim
13 words
The method of claim 39 wherein the somatotropin is a microbially expressed somatotropin.
Claim 47
Dependent Claim
13 words
The method of claim 40 wherein the microbially expressed somatotropin is bovine somatotropin.
Claim 48
Dependent Claim
11 words
The method of claim 41 wherein the bovine somatotropin is MBS.
Claim 49
Dependent Claim
15 words
The method of claim 41 in which the microbially expressed bovine somatotropin is ala-val BST.
Claim 50
Dependent Claim
13 words
The method of claim 40 wherein the microbially expressed somatotropin is porcine somatotropin.
Claim 51
Dependent Claim
13 words
The method of claim 44 in which the microbially expressed somatotropin is APS.
Claim 52
Dependent Claim
24 words
The method of claim 44 wherein the porcine somatotropin is copper-associated somatotropin or a dry blend of a copper salt and a porcine somatotropin.
Claim 53
Dependent Claim
19 words
The method of claim 46 wherein the shaped article has a copper content from about 0.1% to about 3%.
Claim 54
Independent Claim
81 words
A method of prolonged administration of a somatotropin to an animal comprising parenteral implantation of a shaped article consisting essentially of a. an effectiye dose of a solid somatotropin selected from the group consisting of microbially expressed bovine and porcine somatotropin; b. optionally, an effective amount of a lubricant; and c. optionally, a coating on one or more surfaces of the article, which substantially inhibits release of the somatotropin from the coated surfaces, but with at least one uncoated release surface.
Claim 55
Independent Claim
81 words
A method of prolonged administration of a somatotropin to an animal comprising parenteral implantation of a shaped article consisting essentially of a. an effectiye dose of a solid somatotropin selected from the group consisting of microbially expressed bovine and porcine somatotropin; b. optionally, an effective amount of a lubricant; and c. optionally, a coating on one or more surfaces of the article, which substantially inhibits release of the somatotropin from the coated surfaces, but with at least one uncoated release surface.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-04 | 1993-03-06 | 1993-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-04 | 1997-03-06 | 1997-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-04 | 2001-03-06 | 2001-09-05 | $7700.00 | Window Closed / Lapsed |