US4871549A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Time-controlled explosion systems and processes for preparing the same
Assignee: Astellas Pharma Inc
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Filing: 1986-07-10
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Granted: 1989-10-03
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Expires: 2006-07-10
Abstract
Abstract The invention relates to a Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core, a drug, swelling agent and an outer membrane of water-insoluble coating material.
Inventors
- 👤 Yoshio Ueda
- 👤 Takehisa Hata
- 👤 Hisami Yamaguchi
- 👤 Satoshi Ueda
- 👤 Masateru Kodani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 09:33
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5084; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866; A61K9/5073; A61K9/5078
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
76 words
A Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core which is covered with an outer layer of drug, a further outer layer of disintegrating agent or synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid, and an outer membrane of a water-insoluble coating material.
Claim 2
Dependent Claim
76 words
A Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core which is covered with an outer layer of drug, a further outer layer of disintegrating agent or synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid, and an outer membrane of a water-insoluble coating material.
Claim 3
Dependent Claim
73 words
A Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core of a drug which is covered with an outer layer of disintegrating agent of synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid, and an outer membrane of a water-insoluble coating material.
Claim 4
Dependent Claim
73 words
A Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core of a drug which is covered with an outer layer of disintegrating agent of synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid, and an outer membrane of a water-insoluble coating material.
Claim 5
Dependent Claim
75 words
A Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core which is covered with an outer layer of the mixture of drug and disintegrating agent of synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid, and an outer membrane of a water-insoluble coating material.
Claim 6
Dependent Claim
75 words
A Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core which is covered with an outer layer of the mixture of drug and disintegrating agent of synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid, and an outer membrane of a water-insoluble coating material.
Claim 7
Dependent Claim
20 words
A Time-Controlled Explosion System according to any one of claims 1 to 3, wherein the water-insoluble coating material comprises ethylcelluose.
Claim 8
Dependent Claim
27 words
A Time-Controlled Exposion System according to any one of claims 1 to 3, wherein the disintegrating agent is low substituted hydroxypropylcellulose, sodium starch glycolate or carboxymethylcellulose sodium.
Claim 9
Dependent Claim
31 words
A Time-Controlled Explosion System according to any one of claims 1 to 3, characterized in mixing systems which have different lag times to obtain sustained release preparations with various release patterns.
Claim 10
Independent Claim
66 words
A method for preparing a Time-Controlled Explosion System in which drug release is caused by the explosion of a membrane after a definite time period characterized in that after preparing beads or granules comprising a drug, a disintegrating agent or synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid is firstly coated thereon, and then a water-insoluble coating material is further coated thereon.
Claim 11
Independent Claim
66 words
A method for preparing a Time-Controlled Explosion System in which drug release is caused by the explosion of a membrane after a definite time period characterized in that after preparing beads or granules comprising a drug, a disintegrating agent or synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid is firstly coated thereon, and then a water-insoluble coating material is further coated thereon.
Claim 12
Independent Claim
59 words
A method for preparing a Time-Controlled Explosion System in which drug release is caused by the explosion of a membrane after a definite time period characterized in that after preparing beads or granules comprising a drug and disintegrating agent or synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid, a water-insoluble coating material is coated thereon.
Claim 13
Independent Claim
59 words
A method for preparing a Time-Controlled Explosion System in which drug release is caused by the explosion of a membrane after a definite time period characterized in that after preparing beads or granules comprising a drug and disintegrating agent or synthesized polymer selected from the group consisting of polyvinylacetate and polyacrylic acid, a water-insoluble coating material is coated thereon.
References Cited (Backward Citations)
FR848389A
Cited
DE1617724A1
Cited
EP0077956A1
Cited
US4369172A
Cited
US4663150A
Cited
US4695467A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-02 | 1993-04-03 | 1993-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-02 | 1997-04-03 | 1997-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-02 | 2001-04-03 | 2001-10-03 | $7700.00 | Window Closed / Lapsed |