US4882314A
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A composition and method of treating selected malignant conditions
Assignee: Kaken Pharmaceutical Co Ltd
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Filing: 1987-08-04
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Granted: 1989-11-21
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Expires: 2007-08-04
Abstract
Abstract Disclosed is a novel carcinostatic composition comprising 4,6-0-benzylidene-D-glucopyranose as the active ingredient. This active ingredient exerts a very high carcinostatic activity according to a specific carcinostatic mechanism quite different from that of conventional carcinostatic chemotherapeutic agents. The active ingredient is very low in toxicity and is highly stable and water-soluble. This composition is effective against selected malignant conditions which are carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver and malignancies induced by SV40 virus.
Inventors
- 👤 Setsuo Takeuchi
- 👤 Mutsuyuki Kochi
- 👤 Akira Kawarada
- 👤 Shinichiro Esumi
- 👤 Kaguya Sasaki
- 👤 Shozo Kawabata
- 👤 Tsuneo Saita
- 👤 Yukio Inoue
- 👤 Makoto Yamamoto
- 👤 Keiji Sekine
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 02:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7004
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
113 words
A composition, effective against a malignant condition which is carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver or malignancies induced by SV 40 virus, which comprises 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of a sterile injection preparation or a sterile intravenous drip preparation in unit dosage form containing a dosage of about 0.5 to about 5000 mg of 4,6-O-Benzylidene-D-glucopyranose in the liquid concentration, wherein the injection preparation is in the form of a solution, emulsion, suspension or oil base and the intravenous drip preparation is in the form of a sterile solution, emulsion or suspension, and at least one inert carrier.
Claim 2
Dependent Claim
113 words
A composition, effective against a malignant condition which is carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver or malignancies induced by SV 40 virus, which comprises 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of a sterile injection preparation or a sterile intravenous drip preparation in unit dosage form containing a dosage of about 0.5 to about 5000 mg of 4,6-O-Benzylidene-D-glucopyranose in the liquid concentration, wherein the injection preparation is in the form of a solution, emulsion, suspension or oil base and the intravenous drip preparation is in the form of a sterile solution, emulsion or suspension, and at least one inert carrier.
Claim 3
Dependent Claim
40 words
A preparation according to claim 1, which comprises 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of a sterile intraperitoneal injection preparation or a sterile intravenous drip preparation containing a dosage of about 20 to about 200 mg of 4,6-O-benzylidene-D-glucopyranose.
Claim 4
Dependent Claim
72 words
A composition, effective against a malignant condition which is carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver or malignancies induced by SV 40 virus, which comprises 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of an enteric tablet or enteric granule or a capsule containing a dosage of about 1.5 to about 15000 mg of 4,6-O-benzylidene-D-glucopyranose and at least one inert carrier.
Claim 5
Dependent Claim
72 words
A composition, effective against a malignant condition which is carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver or malignancies induced by SV 40 virus, which comprises 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of an enteric tablet or enteric granule or a capsule containing a dosage of about 1.5 to about 15000 mg of 4,6-O-benzylidene-D-glucopyranose and at least one inert carrier.
Claim 6
Dependent Claim
33 words
The composition according to claim 3, wherein the inert carrier is a member selected from the group consisting of surface active agents, excipients, lubricants, adjuvants, pharmaceutically acceptable film forming agents and coating assistants.
Claim 7
Independent Claim
97 words
A method of causing at least temporary relief to humans and animals suffering from a malignant condition which is carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver or malignancies induced by SV 40 virus, which consists of administering to said humans and animals an amount effective to cause regression of the carcinoma of a composition comprising 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of an injection preparation or an intravenous drip preparation containing a dosage of about 0.5 to about 5000 mg per day of 4,6-O-benzylidene-D-glucopyranose.
Claim 8
Independent Claim
97 words
A method of causing at least temporary relief to humans and animals suffering from a malignant condition which is carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver or malignancies induced by SV 40 virus, which consists of administering to said humans and animals an amount effective to cause regression of the carcinoma of a composition comprising 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of an injection preparation or an intravenous drip preparation containing a dosage of about 0.5 to about 5000 mg per day of 4,6-O-benzylidene-D-glucopyranose.
Claim 9
Dependent Claim
20 words
The method according to claim 5, wherein the dosage is about 20 to about 200 mg per day of 4,6-O-benzylidene-D-glucopyranose.
Claim 10
Independent Claim
98 words
A method of causing at least temporary relief to humans and animals suffering from a malignant condition which is carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver or malignancies induced by SV 40 virus, which consists of administering to said humans and animals an amount effective to cause regression of the carcinoma of a composition comprising 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of an enteric tablet or enteric granule or a capsule containing a dosage of about 1.5 to about 15000 mg per day of 4,6-O-benzylidene-D-glucopyranose.
Claim 11
Independent Claim
98 words
A method of causing at least temporary relief to humans and animals suffering from a malignant condition which is carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver or malignancies induced by SV 40 virus, which consists of administering to said humans and animals an amount effective to cause regression of the carcinoma of a composition comprising 4,6-O-benzylidene-D-glucopyranose as the active ingredient in the form of an enteric tablet or enteric granule or a capsule containing a dosage of about 1.5 to about 15000 mg per day of 4,6-O-benzylidene-D-glucopyranose.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-20 | 1993-05-22 | 1993-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-20 | 1997-05-22 | 1997-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-20 | 2001-05-22 | 2001-11-21 | $7700.00 | Window Closed / Lapsed |