US4883668A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Material for endermic administration pre-treatment
Assignee: Advance KK
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Filing: 1989-02-15
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Granted: 1989-11-28
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Expires: 2009-02-15
Abstract
Abstract A material for endermic administration pre-treatment is disclosed wherein the material comprises a support and a substance capable of removing corneum, for example, an adhesive, and the substance is substantially uniformly distributed on the support in the form of small areas discontinuous to each other at a density of 0.001 to 5%. Pre-treatment of the skin by this material enhances the absorption of a medicament in an endermic administration.
Inventors
- 👤 Midori Ohta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 03:10
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61M; A61M35/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
124 words
In inontophoretic transdermal drug administration, the improved method which comprises pre-treating a portion of the skin to which the drug administration is to be made by pressing a substance capable of removing stratum corneum, and which is substantially uniformly distributed on a support in the form of small areas discontinuous to each other at a density of 0.001 to 5%, against a portion of the skin to which the drug administration is to be made, adhering said substance to the stratum corneum on said skin, and removing the substance together with the support from the skin so as to remove a portion of the stratum corneum and provide fine openings in the stratum corneum having reduced impedance and permitting enhanced iontophoretic transdermal drug administration.
Claim 2
Dependent Claim
124 words
In inontophoretic transdermal drug administration, the improved method which comprises pre-treating a portion of the skin to which the drug administration is to be made by pressing a substance capable of removing stratum corneum, and which is substantially uniformly distributed on a support in the form of small areas discontinuous to each other at a density of 0.001 to 5%, against a portion of the skin to which the drug administration is to be made, adhering said substance to the stratum corneum on said skin, and removing the substance together with the support from the skin so as to remove a portion of the stratum corneum and provide fine openings in the stratum corneum having reduced impedance and permitting enhanced iontophoretic transdermal drug administration.
Claim 3
Dependent Claim
21 words
The method according to claim 1, wherein said substance capable of removing stratum corneum is an adhesive substantially non-toxic to skin.
Claim 4
Dependent Claim
14 words
The method according to claim 2, wherein said adhesive is a pressure sensitive adhesive.
Claim 5
Dependent Claim
15 words
The method according to claim 3, wherein said pressure sensitive adhesive is a capsular adhesive.
Claim 6
Dependent Claim
21 words
The method according to claim 3, wherein said pressure sensitive adhesive is a natural adhesive, thermoplastic adhesive or synthetic rubber adhesive.
Claim 7
Dependent Claim
20 words
The method according to claim 1, wherein said small area is a circle having a diameter of about 10-300 μm.
Claim 8
Dependent Claim
20 words
The method according to claim 1, wherein said small area is a strip having a width of about 10-300 μm.
Claim 9
Dependent Claim
13 words
The method according to claim 1 having a density of 0.01 to 5%.
Claim 10
Dependent Claim
13 words
The method according to claim 1, wherein the support is a flexible sheet.
Claim 11
Dependent Claim
13 words
The method according to claim 1, wherein the support is a rigid plate.
Claim 12
Dependent Claim
28 words
The method according to claim 1, wherein the rigid plate has a handle on a surface opposite to a surface carrying the substance capable of removing stratum cornes.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-27 | 1993-05-29 | 1993-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-27 | 1997-05-29 | 1997-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-27 | 2001-05-29 | 2001-11-28 | $7700.00 | Window Closed / Lapsed |