US4883862A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Mercaptosuccinyl glycyl-glycyl-glycine a complex thereof with Tc-99m, and methods of making the same
Assignee: Albert Einstein College of Medicine
•
Filing: 1988-04-13
•
Granted: 1989-11-28
•
Expires: 2008-04-13
Abstract
Abstract The novel compound mercaptosuccinyl glycyl-glycyl-glycine (MSG 3 ) and a stable complex thereof with technetium-99m (Tc-99m) having utility as a renal agent. MSG 3 is made by coupling glycyl-glycyl-glycine with S-acetyl-mercapto succinic anhydride.
Inventors
- 👤 Lakshman R. Chervu
- 👤 Kuldeep K. Bhargava
- 👤 M. Donald Blaufox
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 10:25
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/088; C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0806; A61K2123/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
4 words
The compound mercaptosuccinyl glycyl-glycyl-glycine.
Claim 2
Dependent Claim
4 words
The compound mercaptosuccinyl glycyl-glycyl-glycine.
Claim 3
Dependent Claim
13 words
A compound capable of forming a stable complex with technetium-99m comprising mercaptosuccinyl glycyl-glycyl-glycine.
Claim 4
Dependent Claim
13 words
A compound capable of forming a stable complex with technetium-99m comprising mercaptosuccinyl glycyl-glycyl-glycine.
Claim 5
Dependent Claim
12 words
The compound of claim 2 characterized by utility as a renal agent.
Claim 6
Dependent Claim
11 words
A compound comprising a stable complex of technetium-99m and mercaptosuccinyl glycyl-glycyl-glycine.
Claim 7
Dependent Claim
11 words
A compound comprising a stable complex of technetium-99m and mercaptosuccinyl glycyl-glycyl-glycine.
Claim 8
Dependent Claim
12 words
The compound of claim 4 characterized by utility as a renal agent.
Claim 9
Independent Claim
21 words
A method of forming a compound capable of forming a stable complex with technetium-99m comprising coupling glycyl-glycyl-glycine with S-acetyl-mercapto succinic anhydride.
Claim 10
Independent Claim
21 words
A method of forming a compound capable of forming a stable complex with technetium-99m comprising coupling glycyl-glycyl-glycine with S-acetyl-mercapto succinic anhydride.
Claim 11
Dependent Claim
12 words
The method of claim 6 wherein said compound is a renal agent.
Claim 12
Dependent Claim
9 words
The compound formed by the process of claim 6.
Claim 13
Independent Claim
36 words
A method of forming a radiolabeled compound comprising the steps of: (A) coupling glycyl-glycyl-glycine with S-acetyl-mercapto succinic anhydride to form a compound, and (B) forming a stable complex of technetium-99m and the compound of step (A).
Claim 14
Independent Claim
36 words
A method of forming a radiolabeled compound comprising the steps of: (A) coupling glycyl-glycyl-glycine with S-acetyl-mercapto succinic anhydride to form a compound, and (B) forming a stable complex of technetium-99m and the compound of step (A).
Claim 15
Dependent Claim
12 words
The method of claim 9 wherein said compound is a renal agent.
Claim 16
Dependent Claim
10 words
The radiolabeled compound formed by the process of claim 9.
Claim 17
Dependent Claim
30 words
The compound of claim 4 wherein said stable complex is formed by the reaction of mercaptosuccinyl glycyl-glycyl-glycine and a pertechnetate at room temperature in the presence of a reducing agent.
Claim 18
Dependent Claim
14 words
The compound of claim 12 wherein the stable complex is formed at room temperature.
Claim 19
Dependent Claim
17 words
The method of claim 6 wherein said coupling reaction is performed using equimolar amounts of the reactants.
Claim 20
Dependent Claim
14 words
The method of claim 14 wherein the coupling reaction is conducted at room temperature.
Claim 21
Dependent Claim
36 words
The method of claim 9 wherein the coupling reaction is conducted at room temperature using equimolar amounts of the reactants and the stable complex is formed at room temperature in the presence of a reducing agent.
Claim 22
Dependent Claim
23 words
The method of claim 16 wherein the stable complex is formed with the technitium-99m being initially present in the form of a pertechnetate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-27 | 1993-05-29 | 1993-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-27 | 1997-05-29 | 1997-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-27 | 2001-05-29 | 2001-11-28 | $7700.00 | Window Closed / Lapsed |