US4886499A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Portable injection appliance
Assignee: Hoffmann La Roche Inc
•
Filing: 1987-12-04
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Granted: 1989-12-12
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Expires: 2007-12-04
Abstract
Abstract The portable appliance is of use for the subcutaneous or intradermal injection of a liquid formulation of an active principle and it comprises in combination: a supply vessel for the formulation; an injection needle adapted to communicate with the vessel; pump means for emptying the vessel through the injection needle; securing means for securing the appliance to an appropriate part of the patient's body; and needle-driving means for shooting the injection needle into the patient's skin.
Inventors
- 👤 Giorgio Cirelli
- 👤 Hans Steffen
- 👤 Christian Surber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 02:41
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/178; A61M5/14; A61M5/142; A61M5/145; A61M5/14586; A61M5/14593; A61M5/14244; A61M5/14248; A61M2005/14204; A61M2005/14252; A61M2005/14264; A61M2005/14268; A61M5/168; A61M5/16877; A61M5/16881; Y; Y10; Y10S; Y10S128/00; Y10S128/12
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
177 words
A portable appliance for subcutaneous or intradermal injection of a liquid formulation of an active principle into a patient comprising: a housing having a patient engaging surface to contact a patient's skin; a supply vessel positioned within said housing for storing the liquid formulation; infusion needle means having an infusion needle and positioned in said housing, said means used for establishing communication between said supply vessel and said infusion needle when said infusion needle is activated to advance into the patient's skin a preselected distance; pump means for emptying the liquid formulation from said supply vessel through said infusion needle means; needle driving means for subcutaneous or intradermal injection of the infusion needle through the patient engaging surface and into the patient's skin through an injection site the preselected distance; and securing means for securing the patient engaging surface of the appliance to a portion of the patient's skin substantially surrounding the injection site through which the infusion needle enters the patient's skin thereby providing a tight adherence of the patient engaging surface to the patient's skin.
Claim 2
Dependent Claim
177 words
A portable appliance for subcutaneous or intradermal injection of a liquid formulation of an active principle into a patient comprising: a housing having a patient engaging surface to contact a patient's skin; a supply vessel positioned within said housing for storing the liquid formulation; infusion needle means having an infusion needle and positioned in said housing, said means used for establishing communication between said supply vessel and said infusion needle when said infusion needle is activated to advance into the patient's skin a preselected distance; pump means for emptying the liquid formulation from said supply vessel through said infusion needle means; needle driving means for subcutaneous or intradermal injection of the infusion needle through the patient engaging surface and into the patient's skin through an injection site the preselected distance; and securing means for securing the patient engaging surface of the appliance to a portion of the patient's skin substantially surrounding the injection site through which the infusion needle enters the patient's skin thereby providing a tight adherence of the patient engaging surface to the patient's skin.
Claim 3
Dependent Claim
27 words
The apliance of claim 30 wherein said injection needle means further comprises: flow control means for controlling the flow of the liquid formulation through the injection needle.
Claim 4
Dependent Claim
26 words
The appliance of claim 1, wherein the supply vessel is in the form of a plunger syringe having a cylinder which is operative as supply vessel.
Claim 5
Dependent Claim
12 words
The appliance of claim 1, having at least one additional supply vessel.
Claim 6
Dependent Claim
13 words
The appliance of claim 1, wherein the pump means comprise a mechanical drive.
Claim 7
Dependent Claim
12 words
The appliance of claim 5, wherein the mechanical drive comprises a spring.
Claim 8
Dependent Claim
19 words
The appliance of claim 6, wherein only a fraction of a spring deflection of a driving spring is used.
Claim 9
Dependent Claim
13 words
The appliance of claim 5 wherein the mechanical drive comprises a memory alloy.
Claim 10
Dependent Claim
13 words
The appliance of claim 5 wherein the mechanical drive comprises a clockwork drive.
Claim 11
Dependent Claim
17 words
The appliance of claim 1, wherein the securing means is in the form of an adhesive layer.
Claim 12
Dependent Claim
13 words
The appliance of claim 10, wherein the advesive layer contains a local anesthetic.
Claim 13
Dependent Claim
12 words
The appliance of claim 1, wherein the securing means comprise a plaster.
Claim 14
Dependent Claim
17 words
The appliance of claim 1, wherein the injection has a diameter of less than about 0.05 mm.
Claim 15
Dependent Claim
23 words
The appliance of claim 1, wherein the needle-driving means is combined with a valve controlling communication between the supply vessel and the needle.
Claim 16
Dependent Claim
28 words
The appliance of claim 1, wherein electronic control means for controlling the pump means are provided, the control means having a data memory for a programmed release profile.
Claim 17
Dependent Claim
33 words
The appliance of claim 1, wherein the pump means is in the form of a squeezable hose pump which is of variable hose cross-section and which enables the release profile to be programmed.
Claim 18
Dependent Claim
23 words
The appliance of claim 1, wherein the needle-driving means are designed for a penetration depth of from about 0.5 to about 5 mm.
Claim 19
Dependent Claim
18 words
The appliance of claim 1, further comprising sensor means to control or vary the release rate of formulation.
Claim 20
Dependent Claim
16 words
The appliance of claim 1 wherein the supply vessel is a supply chamber of the appliance.
Claim 21
Dependent Claim
19 words
The appliance of claim 19 wherein the pump means comprises a diaphragm separating the supply chamber into two subchambers.
Claim 22
Dependent Claim
46 words
The appliance of claim 1 wherein the pump means further comprises a pump chamber separated from said supply vessel by a resilient diaphragm; and pressure producing means positioned in said pump chamber for producing a preselected pressure to empty said supply vessel of said liquid formulation.
Claim 23
Dependent Claim
16 words
The appliance according to claim 21, wherein the pump chamber is filled with a propellant vapour.
Claim 24
Dependent Claim
17 words
The appliance according to claim 21 wherein the pressure producing means comprises an electrochemical pressure producing device.
Claim 25
Dependent Claim
18 words
The appliance according to claim 23, wherein said electrochemical pressure producing device is an electro-osmtic or osmotic pump.
Claim 26
Dependent Claim
34 words
The appliance according to claim 21 wherein said pressure producing means further comprises: a device having photochemical means for producing pressure to empty the liquid formulation from said supply vessel using a photochemical reaction.
Claim 27
Dependent Claim
29 words
The appliance according to claim 21 wherein said pressure-producing means further comprises: a device having chemical means for producing pressure to empty the supply vessel using a chemical reaction.
Claim 28
Dependent Claim
27 words
The appliance according to claim 1, wherein the supply vessel defines a closable aperture used to fill said vessel; and a partition means for closing said aperture.
Claim 29
Dependent Claim
30 words
The appliance according to claim 1 wherein the housing is divided into a reusable part and a discardable part, the reusable part comprising driving means for driving the pump means.
Claim 30
Dependent Claim
26 words
The appliance according to claim 28, wherein the discardable part comprises the supply vessel, the infusion needle means, the pump means and the needle driving means.
Claim 31
Dependent Claim
13 words
The appliance of claim 1 wherein the supply vessel is a compressible reservoir.
Claim 32
Dependent Claim
16 words
The appliance of claim 30 wherein the compressible reservoir is in the form of a bellows.
Claim 33
Dependent Claim
23 words
The appliance of claim 31, further comprising an absorbent material which is provided in the supply vessel to take up the active principle.
Claim 34
Dependent Claim
13 words
The appliance of claim 1 wherein the pump means comprises an electic drive.
Claim 35
Dependent Claim
13 words
The appliance of claim 33 wherein the electric drive is an electric pump.
Claim 36
Dependent Claim
13 words
The appliance of claim 34 wherein the electric drive is a piezoelectric pump.
Claim 37
Dependent Claim
13 words
The appliance of claim 34 wherein the electric drive is a diaphragm pump.
Claim 38
Dependent Claim
13 words
The appliance of claim 1 wherein the pump means comprises a magnetic drive.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-11 | 1993-06-12 | 1993-12-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-11 | 1997-06-12 | 1997-12-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-11 | 2001-06-12 | 2001-12-12 | $7700.00 | Window Closed / Lapsed |