US4892736A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intra-pocket drug delivery devices for treatment of periodontal diseases
Assignee: ADA Forsyth Institute Inc
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Filing: 1988-06-03
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Granted: 1990-01-09
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Expires: 2008-06-03
Abstract
Abstract Therapeutic agent delivery devices and methods for using them in treatment of dental disease are disclosed. In the treatment of periodontal disease, a therapeutic agent such as tetracycline mixed in a polymeric matrix such as ethylene vinyl acetate copolymer is packed into the area to be treated and kept in place for a suitable time, during which the therapeutic agent diffuses out of the polymeric matrix, providing continuous therapy for the treatment site.
Inventors
- 👤 J. Max Goodson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:35
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61K6/00; A61K6/30; A61C; A61C19/00; A61C19/06; A61C19/063
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
191 words
A therapeutic agent delivery and maintenance system suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket and maintaining it there, comprising: (a) therapeutic material selected from the group of therapeutic agents consisting of antibacterials, antibiotics, antiinflammatory agents, immune-suppressive agents, immune-stimulatory agents, dentinal desensitizers, odor masking agents, immune reagents, anesthetics, nutritional agents, antioxidants, lipopolysaccharide complexing agents, and peroxides; (b) biocompatible polymeric material selected from the group of polymers consisting of collagen, cellulosic polymers, glycolic acid polymers, methacrylate polymers, ethylene vinyl acetate copolymers, ethylene vinyl alcohol copolymers, and polycaprolactone; said polymeric material containing said therapeutic material impregnated therein and being permeable to said therapeutic material; said polymeric material being in the form of a fiber having a diameter of 0.1 to 1 mm and being sufficiently formable and flexible to conform to the site to be treated; and (c) means, separate from the therapeutic agent-containing polymeric material, for maintaining said therapeutic agent-containing polymeric material within said periodontal pocket in contact with the site to be treated, said maintaining means also serving to limit diffusion of said therapeutic agent from said pocket.
Claim 2
Dependent Claim
191 words
A therapeutic agent delivery and maintenance system suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket and maintaining it there, comprising: (a) therapeutic material selected from the group of therapeutic agents consisting of antibacterials, antibiotics, antiinflammatory agents, immune-suppressive agents, immune-stimulatory agents, dentinal desensitizers, odor masking agents, immune reagents, anesthetics, nutritional agents, antioxidants, lipopolysaccharide complexing agents, and peroxides; (b) biocompatible polymeric material selected from the group of polymers consisting of collagen, cellulosic polymers, glycolic acid polymers, methacrylate polymers, ethylene vinyl acetate copolymers, ethylene vinyl alcohol copolymers, and polycaprolactone; said polymeric material containing said therapeutic material impregnated therein and being permeable to said therapeutic material; said polymeric material being in the form of a fiber having a diameter of 0.1 to 1 mm and being sufficiently formable and flexible to conform to the site to be treated; and (c) means, separate from the therapeutic agent-containing polymeric material, for maintaining said therapeutic agent-containing polymeric material within said periodontal pocket in contact with the site to be treated, said maintaining means also serving to limit diffusion of said therapeutic agent from said pocket.
Claim 3
Dependent Claim
28 words
The system of claim 1 wherein the therapeutic material is tetracycline or a pharmaceutically-acceptable acid addition salt thereof; and the polymeric material is an ethylene vinyl acetate copolymer.
Claim 4
Dependent Claim
27 words
The therapeutic agent delivery and maintenance system of claim 1 wherein said polymeric material contains said therapeutic material at a level of 10 to 50% by weight.
Claim 5
Dependent Claim
28 words
The therapeutic agent delivery and maintenance system of claim 1 wherein said means for maintaining the therapeutic agent-containing material in the periodontal pocket comprises an inert periodontal dressing.
Claim 6
Dependent Claim
28 words
The therapeutic agent delivery and maintenance system of claim 1 wherein said means for maintaining the therapeutic agent-containing material in the periodontal pocket comprises a biocompatible polymeric material.
Claim 7
Dependent Claim
27 words
The therapeutic agent delivery and maintenance system of claim 1 wherein said means for maintaining the therapeutic agent-containing material in the periodontal pocket comprises a metal cap.
Claim 8
Dependent Claim
27 words
The therapeutic agent delivery and maintenance system of claim 1 wherein said means for maintaining the therapeutic agent-containing material in the periodontal pocket comprises an elastic band.
Claim 9
Dependent Claim
26 words
The therapeutic agent delivery and maintenance system of claim 1 wherein said means for maintaining the therapeutic agent-containing material in the periodontal pocket comprises -n-butylcyanoacrylate adhesive.
Claim 10
Dependent Claim
108 words
A therapeutic agent delivery system suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket and maintaining it there, comprising: a fiber of an ethylene vinyl acetate copolymer, said fiber having a diameter of 0.1 to lmm and containing tetracycline or a pharmaceutically-acceptable acid addition salt thereof impregnated therein at a level of 10 to 50% by weight; and means, separate from said tetracycline-containing fiber, for maintaining said tetracycline-containing fiber within said periodontal pocket in contact with the site to be treated, said maintaining means also serving to limit diffusion of said therapeutic agent from said pocket.
Claim 11
Dependent Claim
108 words
A therapeutic agent delivery system suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket and maintaining it there, comprising: a fiber of an ethylene vinyl acetate copolymer, said fiber having a diameter of 0.1 to lmm and containing tetracycline or a pharmaceutically-acceptable acid addition salt thereof impregnated therein at a level of 10 to 50% by weight; and means, separate from said tetracycline-containing fiber, for maintaining said tetracycline-containing fiber within said periodontal pocket in contact with the site to be treated, said maintaining means also serving to limit diffusion of said therapeutic agent from said pocket.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-08 | 1993-07-10 | 1994-01-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-08 | 1997-07-10 | 1998-01-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-08 | 2001-07-10 | 2002-01-09 | $7700.00 | Window Closed / Lapsed |