US4894436A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Homologs of aprotinin produced from a recombinant host, process expression vector and recombinant host therefor and pharaceutical use thereof
Assignee: Bayer AG
•
Filing: 1987-03-23
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Granted: 1990-01-16
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Expires: 2007-03-23
Abstract
Abstract Microbially produced aprotinin and aprotinin homologs used for treating patients suffering from an excess release of pancreatic elastase, serum elastase or leukocyte elastase.
Inventors
- 👤 Ernst-August Auerswald
- 👤 Werner Schroder
- 👤 Eugen Schnabel
- 👤 Wolfgang Bruns
- 👤 Gerd Reinhardt
- 👤 Michael Kotick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:57
CPC Classifications
C; C12; C12N; C12N15/00; C07; C07K; C07K14/00; C07K14/81; C07K14/8107; C07K14/811; C07K14/8114; C07K14/8117; A; A61; A61P; A61P1/00; A61P29/00; A61P9/00; A61P9/14; C12N1/00; C12N15/09; C12N15/10; C12N15/63; C12N15/64; C12N15/67; A61K; A61K38/00; C07K2319/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
29 words
A microbially produced aprotinin or aprotinin homolog which is substituted in position 52 by an amino acid selected from the group consisting of Glu, Leu, Val, Thr and Ser.
Claim 2
Dependent Claim
29 words
A microbially produced aprotinin or aprotinin homolog which is substituted in position 52 by an amino acid selected from the group consisting of Glu, Leu, Val, Thr and Ser.
Claim 3
Dependent Claim
21 words
A microbially produced aprotinin or aprotinin homolog according to claim 1 substituted at position 15 by a naturally occurring amino acid.
Claim 4
Dependent Claim
18 words
A microbially produced aprotinin according to claim 1, wherein the amino acid is any amino acid except methionine.
Claim 5
Dependent Claim
33 words
A microbially produced aprotinin or aprotinin homolog according to claim 2, wherein said amino acid is selected from the group consisting of Arg-15-, Val-15-, Ile-15-, Leu-15-, Phe-15-, Gly-15, Ser-15-, Trp-15-, Tyr-15- and Ala-15-.
Claim 6
Dependent Claim
20 words
A microbially produced aprotinin or aprotinin homolog according to claim 1, wherein the amino acid in position 52 is Glu.
Claim 7
Dependent Claim
31 words
A microbially produced aprotinin or aprotinin homolog according to claim 1, wherein the amino acid at position 15 is Val or Arg and the amino acid at position 52 is Glu.
Claim 8
Dependent Claim
29 words
A microbially produced aprotinin or aprotinin homolog according to claim 1, wherein the amino acid at position 15 is Ile and the amino acid at position 52 is Glu.
Claim 9
Dependent Claim
29 words
A microbially produced aprotinin or aprotinin homolog according to claim 1, wherein the amino acid at position 15 is Leu and the amino acid at position 52 is Glu.
References Cited (Backward Citations)
EP0132732A2
Cited
US4595674A
Cited
EP0157235A1
Cited
EP0168342B1
Cited
WO1986000337A1
Cited
EP0171024B1
Cited
WO1986001229A1
Cited
EP0207402A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-15 | 1993-07-17 | 1994-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-15 | 1997-07-17 | 1998-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-15 | 2001-07-17 | 2002-01-16 | $7700.00 | Window Closed / Lapsed |