US4898920A
Expired / Lapsed
US
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Adhesive compositions, controlled release compositions and transdermal delivery device
Assignee: Dow Silicones Corp
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Filing: 1987-10-15
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Granted: 1990-02-06
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Expires: 2007-10-15
Abstract
Abstract Adhesive compositions comprising blends of polyethylene oxide-grafted silicone polymers with resinous copolymers are disclosed. The adhesive compositions enhance release, in a controlled fashion, of bioactive or chemical agents blended or otherwise dispersed through the compositions. Transdermal drug delivery devices incorporating the adhesive compositions are also disclosed.
Inventors
- 👤 Chi-Long Lee
- 👤 Katherine L. Ulman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:53
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7069; A61K47/00; A61K47/30; A61K47/34; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61L15/585; A61P; A61P25/00; A61P25/30; A61P29/00; A61P43/00; A61P9/00; A61P9/08; A61P9/10; A61P9/12; C; C08; C08G; C08G18/00; C08G18/06; C08G18/28; C08G18/40; C08G18/61; C08G18/70; C08G18/81; C08G18/8108; C08G18/8116; C08G65/00; C08G65/02; C08G65/04; C08G65/06; C08G65/08; C08L; C08L83/00; C09; C09J; C09J183/00; C09J183/04; C09J183/10; C09J183/12
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
180 words
An adhesive composition consisting essentially of a blend of (A) about 10 to 99 wt. % of said composition of a random graft copolymer having the average formula ##STR8## wherein x/y is in the range of 0.01 to 100, inclusive; x+y is in the range of 10 to 1000, inclusive; z is a number less than or equal to 15; R is selected from the group consisting of alkyl radicals having 1 to 8 carbon atoms, aryl radicals and haloalkyl radicals; all R groups can be the same or different; M is H, --COCH═CH 2 , or --CO--NH(CH 2 ) 2 --O--CO--C(CH 3 )═CH 2 ; G is a divalent radical selected from --CH 2 CH 2 CH 2 O--, --CH 2 CH 2 O--, or urethane groups; and (B) correspondingly I to 90 wt. % of a random resinous copolymer consisting essentially of structural units having the formulae R 3 3 SiO 0 .5 and SiO 2 wherein R 3 is a monovalent hydrocarbon radical, said resinous copolymer having an SiOH functionality of at least about 0.5 wt. %.
Claim 2
Dependent Claim
180 words
An adhesive composition consisting essentially of a blend of (A) about 10 to 99 wt. % of said composition of a random graft copolymer having the average formula ##STR8## wherein x/y is in the range of 0.01 to 100, inclusive; x+y is in the range of 10 to 1000, inclusive; z is a number less than or equal to 15; R is selected from the group consisting of alkyl radicals having 1 to 8 carbon atoms, aryl radicals and haloalkyl radicals; all R groups can be the same or different; M is H, --COCH═CH 2 , or --CO--NH(CH 2 ) 2 --O--CO--C(CH 3 )═CH 2 ; G is a divalent radical selected from --CH 2 CH 2 CH 2 O--, --CH 2 CH 2 O--, or urethane groups; and (B) correspondingly I to 90 wt. % of a random resinous copolymer consisting essentially of structural units having the formulae R 3 3 SiO 0 .5 and SiO 2 wherein R 3 is a monovalent hydrocarbon radical, said resinous copolymer having an SiOH functionality of at least about 0.5 wt. %.
Claim 3
Dependent Claim
46 words
The composition of claim 1 wherein G is a urethane group of the formula --R 1 NR 4 C(0)NHR 2 NHC(O)O--wherein R 1 is a divalent alkylene group, R 2 is selected from alkylene and arylene groups and R 4 is H or CH 3 .
Claim 4
Dependent Claim
22 words
The composition of claim 1 wherein said resinous copolymer of (B) comprises at least 5 wt. % of the total of (A)+(B).
Claim 5
Dependent Claim
23 words
The composition of claim 3 wherein said resinous copolymer of (B) comprises between about 30 and wt. % of the total of (A)+(B).
Claim 6
Dependent Claim
23 words
The composition of claim 1 wherein said resinous copolymer of B comprises at least about 50 wt. % of the total of (A)+(B).
Claim 7
Dependent Claim
17 words
The composition of claim 1 wherein at least a portion of said R groups comprise methyl groups.
Claim 8
Dependent Claim
15 words
The composition of claim 6 wherein substantially all of said R groups are methyl groups.
Claim 9
Dependent Claim
18 words
The composition of claim 1 wherein R 3 is an alkyl group having 1 to 8 carbon atoms.
Claim 10
Dependent Claim
17 words
The composition of claim 1 wherein y/(x+y) is in the range of about 0.1 to 0.5, inclusive.
Claim 11
Dependent Claim
17 words
The composition of claim 1 wherein (x+y) is in the range of about 10 to 500, inclusive.
Claim 12
Dependent Claim
21 words
The composition of claim 1 wherein the average value of z is in the range of about 1 to 12.5, inclusive.
Claim 13
Dependent Claim
14 words
The composition of claim 1 wherein the weight ratio of (x+y)/z is about 1.5:1.
Claim 14
Dependent Claim
15 words
The composition of claim 1 wherein G is --CH 2 CH 2 CH 2 O--.
Claim 15
Dependent Claim
26 words
The composition of claim 1 wherein said resinous copolymer of (B) has a number average molecular weight (Mn) in the range of about 2000 to 9000.
Claim 16
Dependent Claim
17 words
The composition of claim 14 wherein said Mn is in the range of about 2000 to 6000.
Claim 17
Dependent Claim
37 words
The composition of claim 14 wherein the molar ratio of R 3 3 SiO 0 .5 units to SiO 2 units in said resinous copolymer of (B) is in the range of about 0.6 to about 2.0.
Claim 18
Dependent Claim
26 words
The composition of claim 14 wherein the SiOH functionality of said resinous copolymer of (B) is in the range of about 0.5 to 5 wt. %.
Claim 19
Dependent Claim
20 words
The composition of claim 17 wherein said SiOH functionality is in the range of about 1 to 3 wt. %.
Claim 20
Dependent Claim
13 words
The composition of claim 1 wherein said resinous copolymer of (B) is endcapped.
Claim 21
Dependent Claim
24 words
The composition of claim 19 wherein said endcapping is present in the form of a functionality selected from hydroxyl, vinyl, acrylate, and mercapto groups.
Claim 22
Dependent Claim
17 words
The composition of claim 1 wherein at least one of said graft and resinous copolymers is crosslinked.
Claim 23
Dependent Claim
11 words
The composition of claim 21 in the form of a membrane.
Claim 24
Dependent Claim
11 words
The composition of claim 1 wherein M is --COCH═CH 2 .
Claim 25
Dependent Claim
17 words
The composition of claim 23 wherein M is --CO--NH(CH 2 ) 2 --O--CO--C(CH 3 )═CH 2 .
References Cited (Backward Citations)
US25727A
Cited
USRE25727E
Cited
US2736721A
Cited
US2814601A
Cited
US2868824A
Cited
US3057469A
Cited
FR1361668A
Cited
US3541127A
Cited
US3483240A
Cited
US3387061A
Cited
GB1201778A
Cited
US3528940A
Cited
US3734097A
Cited
US3797494A
Cited
US3527842A
Cited
US3699963A
Cited
US3965150A
Cited
US3957843A
Cited
US3731683A
Cited
US3742951B1
Cited
US3996934A
Cited
US3742951A
Cited
US3819745A
Cited
US3983298A
Cited
US4151319A
Cited
CA1106993A
Cited
US4235988A
Cited
US4286592A
Cited
GB2115431A
Cited
JPS5936608A
Cited
JPS5936609A
Cited
US4463115A
Cited
US4591622A
Cited
US4584337A
Cited
US4600751A
Cited
EP0188895A1
Cited
DE3502928A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-05 | 1993-08-07 | 1994-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-05 | 1997-08-07 | 1998-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-05 | 2001-08-07 | 2002-02-06 | $7700.00 | Window Closed / Lapsed |