US4900730A
Expired / Lapsed
US
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Preparation which promotes the absorption of peptides
Assignee: Toyo Jozo KK
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Filing: 1987-06-18
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Granted: 1990-02-13
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Expires: 2007-06-18
Abstract
Abstract Medicinal compositions containing a water soluble absorption promoter having chelating activity, preferably in the presence of a salt at a concentration exhibiting higher osmotic pressure than isotonic sodium chloride solution, to promote absorption of the medicine through a gastrointestinal organ such as colon or rectum, and through the vagina.
Inventors
- 👤 Yasuyo Miyauchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 05:46
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/02; A61K47/06; A61K47/08; A61K47/12; A61K47/14; A61K47/16; A61K47/18; A61K47/183; A61K47/20; A61K47/24; A61K47/26; A61K47/30; A61K47/32; A61K47/36; A61K47/38; A61K47/42; A61K9/00; A61K9/0012; A61K9/0031; B; B01; B01F; B01F25/00; B01F25/80; Y; Y10; Y10S; Y10S424/00; Y10S424/15
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
165 words
A rectal composition for promoting improved absorption of medicine through the rectum containing a therapeutically effective amount of water soluble peptide hormone, and additionally containing: (a) from 0.1 to 50 w/w % of at least one water soluble chelating agent selected from the group consisting of oxalic acid, malonic acid, glutaric acid, maleic acid, adipic acid, fumaric acid, trans-asonitic acid, pimelic acid, ethylmalonic acid, iminodiacetic acid, nitrilotriacetic acid, malic acid, lactic acid, glycero-3-phosphoric acid, fructose-1,6-diphosphoric acid, glucuronic acid, galacturonic acid, glyoxylic acid, oxaloacetic acid, α-ketobutyric acid, pyruvic acid, α-ketoglutaric acid, levulinic acid, 3-phenylacetylacetone and ethylacetoacetate, and their salts and their esters, and (b) at least 1 w/w % of a water soluble solute selected from the group consisting of halides, sulfates, phosphates, nitrates amd carbonates of alkali metals, the total concentration of the dissolved chelating agent and solute in an aqueous medium being sufficient so that the composition exhibits an osmotic pressure of 1.5 to 7 times greater than that of isotonic sodium chloride solution.
Claim 2
Dependent Claim
165 words
A rectal composition for promoting improved absorption of medicine through the rectum containing a therapeutically effective amount of water soluble peptide hormone, and additionally containing: (a) from 0.1 to 50 w/w % of at least one water soluble chelating agent selected from the group consisting of oxalic acid, malonic acid, glutaric acid, maleic acid, adipic acid, fumaric acid, trans-asonitic acid, pimelic acid, ethylmalonic acid, iminodiacetic acid, nitrilotriacetic acid, malic acid, lactic acid, glycero-3-phosphoric acid, fructose-1,6-diphosphoric acid, glucuronic acid, galacturonic acid, glyoxylic acid, oxaloacetic acid, α-ketobutyric acid, pyruvic acid, α-ketoglutaric acid, levulinic acid, 3-phenylacetylacetone and ethylacetoacetate, and their salts and their esters, and (b) at least 1 w/w % of a water soluble solute selected from the group consisting of halides, sulfates, phosphates, nitrates amd carbonates of alkali metals, the total concentration of the dissolved chelating agent and solute in an aqueous medium being sufficient so that the composition exhibits an osmotic pressure of 1.5 to 7 times greater than that of isotonic sodium chloride solution.
Claim 3
Dependent Claim
15 words
A rectal composition according to claim 1, wherein said water soluble peptide hormone is calcitonin.
Claim 4
Dependent Claim
28 words
A rectal composition according to claim 1, wherein said composition is in the form of a suppository which further comprises an oily vehicle or a water soluble vehicle.
Claim 5
Dependent Claim
27 words
A rectal composition according to claim 1, wherein said water soluble solute is selected from the group consisting of sulfates, phosphates, nitrates and carbonates of alkali metals.
Claim 6
Dependent Claim
157 words
A rectal composition according for promoting improved absorption of medicine through the rectum containing a therapeutically effective amount of water soluble peptide hormone, and additionally containing: (a) from 0.1 to 50 w/w % of at least one water soluble chelating agent selected from the group consisting of oxalic acid, malonic acid, glutaric acid, maleic acid, adipic acid, fumaric acid, trans-aconitic acid, pimelic acid, ethylmalonic acid, iminodiacetic acid, nitrilotriacetic acid, malic acid, lactic acid, glycero-3-phosphoric acid, fructose-1,6-diphosphoric acid, glucuronic acid, galaturonic acid, glyoxylic acid, oxaloacetic acid, α-ketobutyric acid, pyruvic acid, α-ketoglutaric acid, levulinic acid, 3-phenylacetylacetone, and ethylacetoacetate, and their salts and their esters, and (b) at least 0.25M of a water soluble solute selected from the group consisting of mono- and di-saccharides, the total concentration of dissolved chelating agents and solute in an aqueous medium being sufficient so that the composition exhibits an osmotic pressure of 1.5 to 7 times greater than that of isotonic sodium chloride solution.
Claim 7
Dependent Claim
157 words
A rectal composition according for promoting improved absorption of medicine through the rectum containing a therapeutically effective amount of water soluble peptide hormone, and additionally containing: (a) from 0.1 to 50 w/w % of at least one water soluble chelating agent selected from the group consisting of oxalic acid, malonic acid, glutaric acid, maleic acid, adipic acid, fumaric acid, trans-aconitic acid, pimelic acid, ethylmalonic acid, iminodiacetic acid, nitrilotriacetic acid, malic acid, lactic acid, glycero-3-phosphoric acid, fructose-1,6-diphosphoric acid, glucuronic acid, galaturonic acid, glyoxylic acid, oxaloacetic acid, α-ketobutyric acid, pyruvic acid, α-ketoglutaric acid, levulinic acid, 3-phenylacetylacetone, and ethylacetoacetate, and their salts and their esters, and (b) at least 0.25M of a water soluble solute selected from the group consisting of mono- and di-saccharides, the total concentration of dissolved chelating agents and solute in an aqueous medium being sufficient so that the composition exhibits an osmotic pressure of 1.5 to 7 times greater than that of isotonic sodium chloride solution.
Claim 8
Dependent Claim
15 words
A rectal composition according to claim 5, wherein said water soluble peptide hormone is calcitonin.
Claim 9
Dependent Claim
28 words
A rectal composition according to claim 5, wherein said composition is in the form of a suppository which further comprises an oily vehicle or a water soluble vehicle.
Claim 10
Dependent Claim
18 words
A preparation according to claim 5 wherein the water-soluble saccharide is sorbitol, glucose, mannitol, maltose, lactose or sucrose.
Claim 11
Dependent Claim
21 words
A preparation according to claim 1 wherein the water-soluble peptide hormone has a partition coefficient of 50 or less in chloroform/water.
Claim 12
Dependent Claim
24 words
A preparation according to claim 1 wherein the amount of water soluble chelating agent is in the range from 1.0 to 30 W/W %.
Claim 13
Dependent Claim
24 words
A preparation according to claim 1 wherein the amount of water soluble is in the range of from about 2 to 30 W/W %.
Claim 14
Dependent Claim
21 words
A preparation according to claim 5, wherein the water-soluble peptide hormone has a partition coefficient of 50 or less in chloroform/water.
Claim 15
Dependent Claim
24 words
A preparation according to claim 5 wherein the amount of water soluble chelating agent is in the range from 1.0 to 30 W/W %.
References Cited (Backward Citations)
US3849388A
Cited
EP0031561A2
Cited
GB2092002A
Cited
US4405597A
Cited
US4609640A
Cited
JPH07144214A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-02-12 | 1993-08-14 | 1994-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-12 | 1997-08-14 | 1998-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-12 | 2001-08-14 | 2002-02-13 | $7700.00 | Window Closed / Lapsed |