US4906450A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of arthritis, including rheumatoid arthritis, with the radionuclide, tin SN-121
Assignee: Individual
•
Filing: 1987-03-26
•
Granted: 1990-03-06
•
Expires: 2007-03-26
Abstract
Abstract The radionuclide Tin, Sn-121 in a carrier hydroxide aggregate is disclosed for the treatment of arthritis and, in particular, rheumatoid arthritis of the hands, the interphalangeal joints of the fingers and the metacarpal joints of the hand. The radioactive compound disclosed preferably has a particle size of <90 microns. The beta energy emission associated with Tin, Sn-121 has an energy of 0.38 meV. There are no gamma photons emited during the decay of Tin, Sn-121 to stable Antimony Sb-121. The half life of Tin, Sn-121 is 27.06 hours. The method of preparation of the compound is disclosed along with the method of administration to the patient in need thereof.
Inventors
- 👤 Ephraim Lieberman
- 👤 Maurice E. Bordoni
- 👤 Alfred K. Thornton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 05:24
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K2121/00
Claims Analysis
Total Claims: 66
Claim 1
Independent Claim
17 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with ferric hydroxide.
Claim 2
Dependent Claim
17 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with ferric hydroxide.
Claim 3
Dependent Claim
17 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with aluminum hydroxide.
Claim 4
Dependent Claim
17 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with aluminum hydroxide.
Claim 5
Dependent Claim
20 words
A radioactive suspension for treatment of arthritis wherein said suspension includes a 121Tin compound in aggregation with a metallic hydroxide.
Claim 6
Dependent Claim
20 words
A radioactive suspension for treatment of arthritis wherein said suspension includes a 121Tin compound in aggregation with a metallic hydroxide.
Claim 7
Dependent Claim
12 words
The radioactive suspension of claim 3, wherein the suspension is a macroaggregate.
Claim 8
Dependent Claim
13 words
The suspension of claim 4, wherein the aggregation includes a metallic hydroxide macroaggregate.
Claim 9
Dependent Claim
33 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with a metal hydroxide selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, and Manganese Hydroxide.
Claim 10
Dependent Claim
33 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with a metal hydroxide selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, and Manganese Hydroxide.
Claim 11
Dependent Claim
19 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with a ferric hydroxide macroaggregate.
Claim 12
Dependent Claim
19 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with a ferric hydroxide macroaggregate.
Claim 13
Dependent Claim
19 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with an aluminum hydroxide macroaggregate.
Claim 14
Dependent Claim
19 words
A radioactive suspension for treatment of arthritis including a 121 Tin compound in aggregation with an aluminum hydroxide macroaggregate.
Claim 15
Dependent Claim
41 words
A radioactive suspension for treatment of arthritis including 121 Tin in aggregation with a metal hydroxide, wherein the suspension includes a macroaggregate of a metal hydroxide selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide and Manganese Hydroxide.
Claim 16
Dependent Claim
41 words
A radioactive suspension for treatment of arthritis including 121 Tin in aggregation with a metal hydroxide, wherein the suspension includes a macroaggregate of a metal hydroxide selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide and Manganese Hydroxide.
Claim 17
Dependent Claim
19 words
A radioactive compound for the treatment of arthritis comprising 121 Tin Hydroxide and further including a ferric hydroxide aggregate.
Claim 18
Dependent Claim
19 words
A radioactive compound for the treatment of arthritis comprising 121 Tin Hydroxide and further including a ferric hydroxide aggregate.
Claim 19
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including a ferric hydroxide aggregate.
Claim 20
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including a ferric hydroxide aggregate.
Claim 21
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including a ferric hydroxide macroaggregate.
Claim 22
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including a ferric hydroxide macroaggregate.
Claim 23
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including an aluminum hydroxide aggregate.
Claim 24
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including an aluminum hydroxide aggregate.
Claim 25
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including an aluminum hydroxide macroaggregate.
Claim 26
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including an aluminum hydroxide macroaggregate.
Claim 27
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including a metallic hydroxide aggregate.
Claim 28
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including a metallic hydroxide aggregate.
Claim 29
Dependent Claim
30 words
The compound of claim 15, wherein the metallic hydroxide aggregate is a transition metallic hydroxide selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide and Manganese Hydroxide.
Claim 30
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including a metallic hydroxide macroaggregate.
Claim 31
Dependent Claim
20 words
A radioactive compound for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide and further including a metallic hydroxide macroaggregate.
Claim 32
Dependent Claim
30 words
The compound of claim 17, wherein the metallic hydroxide macroaggregate is a transition metallic hydroxide selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide and Manganese Hydroxide.
Claim 33
Dependent Claim
45 words
A radioactive compound for the treatment of arthritis comprising 121 Tin in a metallic hydroxide aggregate carrier having a particle size of approximately from 1 micron-90 microns, Beta energy emissions of said 121 Tin being substantially 0.38 MeV, and a half-life of approximately 27.06 hours.
Claim 34
Dependent Claim
45 words
A radioactive compound for the treatment of arthritis comprising 121 Tin in a metallic hydroxide aggregate carrier having a particle size of approximately from 1 micron-90 microns, Beta energy emissions of said 121 Tin being substantially 0.38 MeV, and a half-life of approximately 27.06 hours.
Claim 35
Independent Claim
29 words
A method for the treatment of arthritis of an articular joint comprising: administering by injection a therapeutically effective quantity of a suspension including 121 Tin to perform radiation synovectomy.
Claim 36
Independent Claim
29 words
A method for the treatment of arthritis of an articular joint comprising: administering by injection a therapeutically effective quantity of a suspension including 121 Tin to perform radiation synovectomy.
Claim 37
Dependent Claim
20 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide.
Claim 38
Dependent Claim
20 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide.
Claim 39
Dependent Claim
14 words
The radioactive composition of claim 21, wherein the aggregated metal hydroxide is a macroaggregate.
Claim 40
Dependent Claim
27 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the metal hydroxide is ferric hydroxide.
Claim 41
Dependent Claim
27 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the metal hydroxide is ferric hydroxide.
Claim 42
Dependent Claim
28 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the metal hydroxide is an aluminum hydroxide.
Claim 43
Dependent Claim
28 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the metal hydroxide is an aluminum hydroxide.
Claim 44
Dependent Claim
40 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the metal hydroxide is selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, and Manganese Hydroxide.
Claim 45
Dependent Claim
40 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the metal hydroxide is selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, and Manganese Hydroxide.
Claim 46
Dependent Claim
36 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the aggregated metal hydroxide is a macroaggregate, and wherein the metal hydroxide is ferric hydroxide.
Claim 47
Dependent Claim
36 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the aggregated metal hydroxide is a macroaggregate, and wherein the metal hydroxide is ferric hydroxide.
Claim 48
Dependent Claim
37 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the aggregated metal hydroxide is a macroaggregate, and wherein the metal hydroxide is an aluminum hydroxide.
Claim 49
Dependent Claim
37 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the aggregated metal hydroxide is a macroaggregate, and wherein the metal hydroxide is an aluminum hydroxide.
Claim 50
Dependent Claim
49 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the aggregated metal hydroxide is a macroaggregate, and wherein the metal hydroxide is selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, and Manganese Hydroxide.
Claim 51
Dependent Claim
49 words
A radioactive composition for the treatment of arthritis comprising a compound which includes 121 Tin and an aggregated metal hydroxide wherein the aggregated metal hydroxide is a macroaggregate, and wherein the metal hydroxide is selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, and Manganese Hydroxide.
Claim 52
Dependent Claim
19 words
A radioactive composition for the treatment of arthritis comprising 121 Tin Hydroxide with a carrier of ferric hydroxide aggregate.
Claim 53
Dependent Claim
19 words
A radioactive composition for the treatment of arthritis comprising 121 Tin Hydroxide with a carrier of ferric hydroxide aggregate.
Claim 54
Dependent Claim
20 words
A radioactive composition for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide with a carrier of metal hydroxide aggregate.
Claim 55
Dependent Claim
20 words
A radioactive composition for the treatment of rheumatoid arthritis comprising 121 Tin Hydroxide with a carrier of metal hydroxide aggregate.
Claim 56
Dependent Claim
23 words
The radioactive composition of claim 30 wherein the metal hydroxide aggregate is selected from the group consisting of ferric hydroxide and aluminum hydroxide.
Claim 57
Dependent Claim
30 words
The composition of claim 30, wherein the metal hydroxide aggregate is a transition metal hydroxide selected from the group consisting of Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide and Manganese Hydroxide.
Claim 58
Dependent Claim
46 words
A radioactive composition for the treatment of arthritis comprising 121 Tin in a carrier of a metal hydroxide aggregate having a particle size of approximately from 1 micron-90 microns, Beta energy emissions of said 121 Tin substantially 0.38 MeV, and a half-life of approximately 27.06 hours.
Claim 59
Dependent Claim
46 words
A radioactive composition for the treatment of arthritis comprising 121 Tin in a carrier of a metal hydroxide aggregate having a particle size of approximately from 1 micron-90 microns, Beta energy emissions of said 121 Tin substantially 0.38 MeV, and a half-life of approximately 27.06 hours.
Claim 60
Independent Claim
35 words
A method for the treatment of arthritis of an articular joint comprising: administering by injection a therapeutically effective quantity of a composition which includes 121 Tin and an aggregated metal hydroxide to perform radiation synovectomy.
Claim 61
Independent Claim
35 words
A method for the treatment of arthritis of an articular joint comprising: administering by injection a therapeutically effective quantity of a composition which includes 121 Tin and an aggregated metal hydroxide to perform radiation synovectomy.
Claim 62
Dependent Claim
21 words
The method of claim 34 wherein the metal hydroxide is selected from the group consisting of ferric hydroxide and aluminum hydroxide.
Claim 63
Independent Claim
28 words
A method for the treatment of arthritis of an articular joint comprising: administering by injection a therapeutically effective quantity of a composition including 121Tin to perform radiation synovectomy.
Claim 64
Independent Claim
28 words
A method for the treatment of arthritis of an articular joint comprising: administering by injection a therapeutically effective quantity of a composition including 121Tin to perform radiation synovectomy.
Claim 65
Independent Claim
29 words
A method for the treatment of rheumatoid arthritis of an articular joint comprising: administering by injection a therapeutically effective quantity of a composition including 121Tin to perform radiation synovectomy.
Claim 66
Independent Claim
29 words
A method for the treatment of rheumatoid arthritis of an articular joint comprising: administering by injection a therapeutically effective quantity of a composition including 121Tin to perform radiation synovectomy.
References Cited (Backward Citations)
US4511551A
Cited
US4533541A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-05 | 1993-09-04 | 1994-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-05 | 1997-09-04 | 1998-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-05 | 2001-09-04 | 2002-03-06 | $7700.00 | Window Closed / Lapsed |