US4921951A
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Nucleoside-phospholipid conjugate
Assignee: Asahi Kasei Corp
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Filing: 1987-09-28
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Granted: 1990-05-01
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Expires: 2007-09-28
Abstract
Abstract Novel nucleoside-phospholipid conjugates of the formula <IMAGE> wherein R1 is C14-24 long chain aliphatic acyl or C1-24 aliphatic alkyl and Ns is a nucleoside residue; and pharmacologically acceptable salts thereof are prepared in a one-step reaction by reacting the corresponding nucleoside and glycerophospholipid derivative in the presence of phospholipase D-P.
Inventors
- 👤 Satoshi Shuto
- 👤 Hiromichi Itoh
- 👤 Kiyofumi Fukukawa
- 👤 Masatoshi Tsujino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:13
CPC Classifications
C; C07; C07D; C07D473/00; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
34 words
A compound of the formula: ##STR6## wherein R 1 is C 14-24 long chain aliphatic acyl, R 2 is C 2-10 aliphatic acyl and N s is neplanocin A-6'-yl, and pharmacologically acceptable salts thereof.
Claim 2
Dependent Claim
34 words
A compound of the formula: ##STR6## wherein R 1 is C 14-24 long chain aliphatic acyl, R 2 is C 2-10 aliphatic acyl and N s is neplanocin A-6'-yl, and pharmacologically acceptable salts thereof.
Claim 3
Dependent Claim
15 words
Compound according to claim 1 wherein R 1 is C 16-18 long chain aliphatic acyl.
References Cited (Backward Citations)
US4291024A
Cited
JPS59187786A
Cited
JPS6188887A
Cited
JPS6188890A
Cited
US4797479A
Cited
JPH01152694A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-30 | 1993-10-30 | 1994-05-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-30 | 1997-10-30 | 1998-05-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-30 | 2001-10-30 | 2002-05-01 | $7700.00 | Window Closed / Lapsed |