US4931281A — Laminar structure for administering a chemical at…

Claim 1

Independent Claim 113 words

A laminar structure for administering a medicament which comprises: a. a boundary layer; b. a medicament containing layer contiguous to at least a portion of said boundary layer, for maintaining a supply of the medicament, comprising a polymeric resin matrix having dissolved therein a first portion of a mixture of active ingredients of the medicament dissolved therein and a second portion of said mixture dispersed therethrough, said mixture comprising at least two active ingredients of the medicament having different concentration transport rates through said matrix and present in a ratio to each other to give a controlled release of the medicament selected from the group consisting of tiamenidine and a suitable salt thereof.

Claim 2

Dependent Claim 113 words

A laminar structure for administering a medicament which comprises: a. a boundary layer; b. a medicament containing layer contiguous to at least a portion of said boundary layer, for maintaining a supply of the medicament, comprising a polymeric resin matrix having dissolved therein a first portion of a mixture of active ingredients of the medicament dissolved therein and a second portion of said mixture dispersed therethrough, said mixture comprising at least two active ingredients of the medicament having different concentration transport rates through said matrix and present in a ratio to each other to give a controlled release of the medicament selected from the group consisting of tiamenidine and a suitable salt thereof.

Claim 3

Dependent Claim 25 words

The structure of claim 1, which additionally comprises an adhesive layer adjacent to said medicament containing layer for affixing the structure to a host body.

Claim 4

Dependent Claim 23 words

The structure of claim 1 wherein said mixture contained in said matrix comprises a mixture consisting of tiamenidine and a suitable salt thereof.

Claim 5

Dependent Claim 25 words

The structure of claim 1 wherein said matrix comprises a polymeric material selected from the group consisting of polyethylene, polypropylene, ethylene/propylene copolymers, and silicone elastomers.

Claim 6

Dependent Claim 23 words

The structure of claim 1 wherein said mixture contained in said matrix comprises a mixture consisting of piretanide and a suitable salt thereof.

Claim 7

Independent Claim 154 words

A method of administering a drug, comprising at least two different forms of active ingredients, to a patient in need thereof which comprises: contacting a surface of the body of the patient with a controlled drug release device, said device comprising, a drug containing layer contiguous to said surface for containing and providing a controlled release of the drug, having dissolved and dispersed therethrough a mixture comprising a first form of active ingredient and a second form of active ingredient which differs from said first form in the rate at which it is transported through said layer therefrom to said surface, the ratio of dissolved to dispersed mixture and the ratio of first to second forms being selected to give a desired controlled release rate of the drug from said layer to said surface and whereas the mixture of active ingredients is selected from the groups consisting of tiamenidine and a suitable salt thereof.

Claim 8

Independent Claim 154 words

A method of administering a drug, comprising at least two different forms of active ingredients, to a patient in need thereof which comprises: contacting a surface of the body of the patient with a controlled drug release device, said device comprising, a drug containing layer contiguous to said surface for containing and providing a controlled release of the drug, having dissolved and dispersed therethrough a mixture comprising a first form of active ingredient and a second form of active ingredient which differs from said first form in the rate at which it is transported through said layer therefrom to said surface, the ratio of dissolved to dispersed mixture and the ratio of first to second forms being selected to give a desired controlled release rate of the drug from said layer to said surface and whereas the mixture of active ingredients is selected from the groups consisting of tiamenidine and a suitable salt thereof.

Claim 9

Dependent Claim 25 words

The method as defined in claim 6 wherein said device further comprises a boundary layer having at least a portion contacting said drug containing layer.

Claim 10

Dependent Claim 30 words

The method as defined in claim 7 wherein said device further comprises an adhesive layer adjacent to said drug containing layer to affix said drug containing layer to said surface.

Claim 11

Dependent Claim 37 words

The method as defined in claim 7 wherein said device comprises said drug containing layer having a matrix having dissolved therein and dispersed therethrough the drug selected from the group consisting of tiamenidine and a salt thereof.

Claim 12

Dependent Claim 29 words

The method as defined in claim 9 wherein said matrix is fabricated from a polymeric resin selected from the group consisting of polyethylene, polypropylene, ethylene/propylene copolymers and silicone elastomers.

Claim 13

Dependent Claim 34 words

The method as defined in claim 7 wherein said device comprises said drug containing layer having a matrix having dissolved therein and dispersed therethrough a drug mixture consisting of piretanide and a salt thereof.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1993-06-04	1993-12-04	1994-06-05	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1997-06-04	1997-12-04	1998-06-05	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2001-06-04	2001-12-04	2002-06-05	$7700.00	Window Closed / Lapsed

Laminar structure for administering a chemical at a controlled release rate

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