US4931472A
Expired / Lapsed
US
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Fluorinated triethylenediamine as an oxygen transport agent
Assignee: Biomed-Technology Inc
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Filing: 1985-09-17
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Granted: 1990-06-05
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Expires: 2005-09-17
Abstract
Abstract Fluorinated triethylenediamine compounds such as perfluorotriethylenediamine and the novel compounds undecafluorotriethylenediamine and decafluorotriethylenediamine, prepared by indirect fluorination of triethylenediamine by passing triethylenediamine over, e.g., cobalt trifluoride (CoF 3 ), are useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation. The compounds undergo rapid biological elimination due to their low molecular weight.
Inventors
- 👤 William E. Erner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 13:59
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/08
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
36 words
An artificial blood comprising a physiologically acceptable, stable, essentially homogeneous formulation of an effective oxygen-transporting amount of highly fluorinated triethylenediamine dispersed in water, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine, undecafluorotriethylenediamine or decafluorotriethylenediamine, or any combination thereof.
Claim 2
Dependent Claim
36 words
An artificial blood comprising a physiologically acceptable, stable, essentially homogeneous formulation of an effective oxygen-transporting amount of highly fluorinated triethylenediamine dispersed in water, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine, undecafluorotriethylenediamine or decafluorotriethylenediamine, or any combination thereof.
Claim 3
Dependent Claim
17 words
An artificial blood as defined by claim 1, wherein said highly fluorinated triethylenediamine is emulsified in water.
Claim 4
Dependent Claim
13 words
An artificial blood as defined by claim 2, further comprising an emulsifying agent.
Claim 5
Dependent Claim
15 words
An artificial blood as defined by claim 3, wherein said highly fluorinated triethylenediamine comprises perfluorotriethylenediamine.
Claim 6
Dependent Claim
15 words
An artificial blood as defined by claim 3, wherein said highly fluorinated triethylenediamine comprises undecafluorotriethylenediamine.
Claim 7
Dependent Claim
15 words
An artificial blood as defined by claim 3, wherein said highly fluorinated triethylenediamine comprises decafluorotriethylenediamine.
Claim 8
Dependent Claim
21 words
An artificial blood as defined by claim 3, wherein said emulsifying agent is a copolymer of propylene oxide and ethylene oxide.
Claim 9
Dependent Claim
13 words
An artificial blood as defined by claim 3, wherein said formulation is isotonic.
Claim 10
Independent Claim
46 words
A method for replacing blood loss in a mammal, said method comprising intravenously administering a physiologically acceptable, stable, essentially homogeneous formulation of an effective oxygen transporting amount of highly fluorinated triethylenediamine emulsified in water, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine, undecafluorotriethylenediamine, decafluorotriethylenediamine or any combination thereof.
Claim 11
Independent Claim
46 words
A method for replacing blood loss in a mammal, said method comprising intravenously administering a physiologically acceptable, stable, essentially homogeneous formulation of an effective oxygen transporting amount of highly fluorinated triethylenediamine emulsified in water, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine, undecafluorotriethylenediamine, decafluorotriethylenediamine or any combination thereof.
Claim 12
Dependent Claim
29 words
A method for replacing blood loss in a mammal as defined by claim 9, wherein said homogeneous formulation is emulsified with a copolymer of propylene oxide and ethylene oxide.
Claim 13
Dependent Claim
24 words
An artificial blood as defined by claim 1, wherein said highly fluorinated triethylenediamine comprises about 5 to about 75% (W/V) of the artificial blood.
Claim 14
Dependent Claim
24 words
An artificial blood as defined by claim 11, wherein said highly fluorinated triethylenediamine comprises about 10 to about 40% (W/V) of the artificial blood.
Claim 15
Dependent Claim
30 words
A stable, essentially homogeneous dispersion comprising an effective oxygen transporting amount of highly fluorinated triethylenediamine in water, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine, undecafluorotriethylenediamine or decafluorotriethylenediamine, or any combination thereof.
Claim 16
Dependent Claim
30 words
A stable, essentially homogeneous dispersion comprising an effective oxygen transporting amount of highly fluorinated triethylenediamine in water, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine, undecafluorotriethylenediamine or decafluorotriethylenediamine, or any combination thereof.
Claim 17
Dependent Claim
17 words
A stable, essentially homegeneous dispersion as defined by claim 13, wherein said highly fluorinated triethylenediamine comprises perfluorotriethylenediamine.
Claim 18
Dependent Claim
29 words
A stable, essentially homogeneous emulsion comprising an effective oxygen transporting amount of highly fluorinated triethylenediamine in water, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine undecafluorotriethylenediamine, decafluorotriethylenediamine or any combination thereof.
Claim 19
Dependent Claim
29 words
A stable, essentially homogeneous emulsion comprising an effective oxygen transporting amount of highly fluorinated triethylenediamine in water, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine undecafluorotriethylenediamine, decafluorotriethylenediamine or any combination thereof.
Claim 20
Dependent Claim
17 words
A stable, essentially homogeneous emulsion as defined by claim 15, wherein said highly fluorinated triethylenediamine comprises perfluorotriethylenediamine.
Claim 21
Dependent Claim
75 words
A stable emulsion in a physiologically acceptable aqueous medium of highly fluorinated triethylenediamine having a particle size of about 0.005 to about 0.5 μm which comprises about 5 to about 75% (W/V) of the emulsion and an effective surfactant amount of a polymeric nonionic surfactant which is a copolymer of propylene oxide and ethylene oxide having a molecular weight of 2,000 to 20,000, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine, undecafluorotriethylenediamine, decafluorotriethylenediamine or any combination thereof.
Claim 22
Dependent Claim
75 words
A stable emulsion in a physiologically acceptable aqueous medium of highly fluorinated triethylenediamine having a particle size of about 0.005 to about 0.5 μm which comprises about 5 to about 75% (W/V) of the emulsion and an effective surfactant amount of a polymeric nonionic surfactant which is a copolymer of propylene oxide and ethylene oxide having a molecular weight of 2,000 to 20,000, said highly fluorinated triethylenediamine comprising perfluorotriethylenediamine, undecafluorotriethylenediamine, decafluorotriethylenediamine or any combination thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-04 | 1993-12-04 | 1994-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-04 | 1997-12-04 | 1998-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-04 | 2001-12-04 | 2002-06-05 | $7700.00 | Window Closed / Lapsed |