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US4939149A
Expired / Lapsed
US
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Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization
Assignee: United States Department of Health and Human Services
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Filing: 1988-10-24
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Granted: 1990-07-03
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Expires: 2008-10-24
Abstract
Abstract The present invention relates to a method for desensitizing a subject animal, which comprises administering to the subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject animal to neurogenic inflammation, to chemically and thermally induced pain and to responses involving sensory afferent pathways sensitive to capsaicin and to responses involving the hypothalamic temperature control region, and a pharmaceutically acceptable carrier therefor.
Inventors
- 👤 Peter M. Blumberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:02
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
52 words
A method for desensitizing a subject animal, which comprises administering to said subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject to neurogenic inflammation, to chemically and thermally induced pain, to responses involving sensory afferent pathways sensitive to capsaicin or to responses involving the hypothalamic temperature control region.
Claim 2
Independent Claim
52 words
A method for desensitizing a subject animal, which comprises administering to said subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject to neurogenic inflammation, to chemically and thermally induced pain, to responses involving sensory afferent pathways sensitive to capsaicin or to responses involving the hypothalamic temperature control region.
Claim 3
Independent Claim
13 words
The method of claim wherein the resiniferatoxin is administered topically, subcutaneously or intraperitoneally.
Claim 4
Dependent Claim
23 words
The method of claim 1, wherein resiniferatoxin is administered in the range of 1×10 -5 mg/kg to 5×10 -2 mg/kg to the subject.
Claim 5
Dependent Claim
11 words
The method of claim 1, wherein the subject is a mammal.
Claim 6
Dependent Claim
16 words
The method of claim 4, wherein the subject mammal is mouse, rat, domestic animal, or human.
Claim 7
Dependent Claim
19 words
The method of claim 5, wherein the domestic animal is a dog, cat, horse, cow, pig, goat or sheep.
Claim 8
Dependent Claim
15 words
The method of claim 1, wherein the resiniferatoxin is administered by single or multiple application.
Claim 9
Dependent Claim
26 words
The method of claim 1, which comprises administering to said subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject to neurogenic inflammation.
Claim 10
Dependent Claim
29 words
The method of claim 1, which comprises administering to said subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject to chemically and thermally induced pain.
Claim 11
Dependent Claim
32 words
The method of claim 1, which comprises administering to said subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject to responses involving sensory afferent pathways sensitive to capsaicin.
Claim 12
Dependent Claim
31 words
The method of claim 1, which comprises administering to said subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject to responses involving the hypothalamic temperature control region.
References Cited (Backward Citations)
US4716179A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-07-02 | 1994-01-01 | 1994-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-07-02 | 1998-01-01 | 1998-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-07-02 | 2002-01-01 | 2002-07-03 | $7700.00 | Window Closed / Lapsed |