US4960908A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Isoflavone derivatives, salts thereof, and oncostatic and immunosuppressive agents
Assignee: Astellas Pharma Inc
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Filing: 1988-10-21
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Granted: 1990-10-02
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Expires: 2008-10-21
Abstract
Abstract Novel isoflavone derivatives are provided which have the formula ##STR1## and which exhibit cancerocidal and immunosuppressive activity. The invention also provides pharmaceutical compositions containing the derivatives, methods of use and processes for their preparation.
Inventors
- 👤 Noriki Ito
- 👤 Hiroshi Ogawara
- 👤 Shunichi Watanabe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 07:04
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/26; C07D311/34; C07D311/36; A; A61; A61P; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P43/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
100 words
An isoflavone derivative represented by the Formula (I) and salts thereof: ##STR27## wherein R 1 represents ##STR28## in which A denotes a lower alkylene group; R 3 and R 4 are each a hydrogen atom, a lower alkyl, a cycloalkyl or a sulfur- and nitrogen-containing 5-or 6-membered heterocyclic groups, which three groups may optionally be substituted by one or two hydroxyl groups, or R 3 and R 4 may be taken together to form, in conjunction with the nitrogen atom to which they are attached, pyrrolidine, piperidine or morpholine ring; and R 2 is hydroxyl, or a lower alkoxy radical.
Claim 2
Dependent Claim
100 words
An isoflavone derivative represented by the Formula (I) and salts thereof: ##STR27## wherein R 1 represents ##STR28## in which A denotes a lower alkylene group; R 3 and R 4 are each a hydrogen atom, a lower alkyl, a cycloalkyl or a sulfur- and nitrogen-containing 5-or 6-membered heterocyclic groups, which three groups may optionally be substituted by one or two hydroxyl groups, or R 3 and R 4 may be taken together to form, in conjunction with the nitrogen atom to which they are attached, pyrrolidine, piperidine or morpholine ring; and R 2 is hydroxyl, or a lower alkoxy radical.
Claim 3
Dependent Claim
10 words
The isoflavone derivative of claim 1, which is 2-(dimethylaminomethyl)-5,7-dihydroxy-4'-methoxyisoflavone hydrochloride.
References Cited (Backward Citations)
US3352754A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-01 | 1994-04-02 | 1994-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-01 | 1998-04-02 | 1998-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-01 | 2002-04-02 | 2002-10-02 | $7700.00 | Window Closed / Lapsed |