US4994444A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Macromolecules for sealing capillary endothelial junctions
Assignee: Columbia University
•
Filing: 1987-07-31
•
Granted: 1991-02-19
•
Expires: 2007-07-31
Abstract
Abstract The present invention provides compositions of matter and methods for treating a human subject to prevent leakage of serum albumin from capillary endothelial junctions during a period of increased capillary permeability. The method comprises administering to the human subject an effective capillary pore sealing amount of a macromolecule which is biodegradable, non-toxic, globular in shape, with a molecular weight range from about 100,000 daltons to about 1,000,000 daltons and a pharmaceutically acceptable carrier. The composition of matter comprises a fraction derived from hydroxyethyl starch.
Inventors
- 👤 Bashir A. Zikria
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 01:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
69 words
A method of treating a human subject suffering from trauma to prevent leakage of serum albumin from capillary endothelial junctions during a period of increased capillary permeability which comprises administering to the human subject an effective capillary sealing amount of a macromolecule which is biodegradable, non-toxic, globular in shape, and has a molecular weight within the range above 100,000 daltons to about 1,000,000 daltons in a pharmaceutically acceptable carrier.
Claim 2
Independent Claim
69 words
A method of treating a human subject suffering from trauma to prevent leakage of serum albumin from capillary endothelial junctions during a period of increased capillary permeability which comprises administering to the human subject an effective capillary sealing amount of a macromolecule which is biodegradable, non-toxic, globular in shape, and has a molecular weight within the range above 100,000 daltons to about 1,000,000 daltons in a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
27 words
A method of claim 1, wherein the human subject is suffering from trauma associated with a burn, shock, ischemia, organ transplantation, or a pre- or postsurgical technique.
Claim 4
Dependent Claim
11 words
A method of claim 1, wherein the macromolecule is administered intravenously.
Claim 5
Dependent Claim
13 words
A method of claim 1, wherein the macromolecule is derived from hydroxyethyl starch.
Claim 6
Dependent Claim
30 words
A method of claim 4, wherein the macromolecule comprises a fraction derived from hydroxyethyl starch and has a molecular weight within the range from about 100,000 to about 300,000 daltons.
Claim 7
Dependent Claim
30 words
A method of claim 4, wherein the macromolecule comprises a fraction derived from hydroxyethyl starch and has a molecular weight within the range from about 300,000 to about 1,000,000 daltons.
Claim 8
Dependent Claim
11 words
A method of claim 1, wherein the macromolecule comprises a dextran.
Claim 9
Dependent Claim
23 words
A method of claim 7, wherein the dextran has a molecular weight within the range from about 100,000 daltons to about 200,000 daltons.
Claim 10
Dependent Claim
19 words
A method of claim 7, wherein the dextran has a molecular weight of about 200,000 to about 400,000 daltons.
Claim 11
Dependent Claim
16 words
A method of claim 7, wherein the dextran has a molecular weight of about 500,000 daltons.
Claim 12
Dependent Claim
10 words
A method of claim 1, wherein the macromolecule comprises glycogen.
Claim 13
Dependent Claim
22 words
A method of claim 11, wherein the glycogen has a molecular weight within the range from about 270,000 to about 350,000 daltons.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-02-18 | 1994-08-20 | 1995-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-02-18 | 1998-08-20 | 1999-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-02-18 | 2002-08-20 | 2003-02-19 | $7700.00 | Window Closed / Lapsed |