US4997643A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymeric salt delivery systems
Assignee: Union Carbide Chemicals and Plastics Technology LLC
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Filing: 1989-07-12
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Granted: 1991-03-05
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Expires: 2009-07-12
Abstract
Abstract A biocompatible, film-forming delivery system for the delivery of pharmaceutical or therapeutic actives to a desired topical site of a subject, the system including: an active salt compound, wherein the active salt compound is at least a partial salt of (1) a carboxylic acid moiety-containing, biocompatible, film-forming polymer with (2) at least one active selected from the group consisting of pharmaceutical actives, therapeutic actives and a combination thereof, wherein the at least one active is capable of complexing with at least one carboxylic acid moiety of the polymer to form the active salt compound, and wherein the active salt compound forms an active salt compound film on the topical site and the active salt compound disassociates into the polymer and the at least one active while the delivery system is in contact with the topical site such that the polymer remains thereon as a polymer film and the at least one active is delivered to the topical site in an absorbable form.
Inventors
- 👤 Emmett M. Partain, III
- 👤 II George L. Brode
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 11:54
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/0066; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/59; A61K9/00; A61K9/70; A61K9/7015; A61L2300/00; A61L2300/20; A61L2300/204; A61L2300/60; A61L2300/602; A61L2300/80
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
185 words
A biocompatible, film-forming delivery system for delivery of pharmaceutically or therapeutically effective amount of actives to a desired topical site of a subject, said system comprising: an active salt compound, wherein said active salt compound is at least a partial salt of (1) a carboxylic acid moiety-containing, biocompatible, film-forming polymer said carboxylic acid moiety-containing polymer being selected from the group consisting of polycarboxylic acid polymers and cyclic anhydride moiety containing polymers with (2) at least one active selected from the group consisting of pharmaceutical actives, therapeutic actives and a combination thereof, wherein said at least one active is capable of complexing with at least one carboxylic acid moiety of said polymer to form said active salt compound, and wherein said active salt compound forms an active salt compound film on said topical site and said active salt compound disassociates into said polymer and said at least one active while said delivery system is in contact with said topical site such that said polymer remains thereon as a polymer film and said at least one active is delivered to said topical site in an absorbable form.
Claim 2
Dependent Claim
185 words
A biocompatible, film-forming delivery system for delivery of pharmaceutically or therapeutically effective amount of actives to a desired topical site of a subject, said system comprising: an active salt compound, wherein said active salt compound is at least a partial salt of (1) a carboxylic acid moiety-containing, biocompatible, film-forming polymer said carboxylic acid moiety-containing polymer being selected from the group consisting of polycarboxylic acid polymers and cyclic anhydride moiety containing polymers with (2) at least one active selected from the group consisting of pharmaceutical actives, therapeutic actives and a combination thereof, wherein said at least one active is capable of complexing with at least one carboxylic acid moiety of said polymer to form said active salt compound, and wherein said active salt compound forms an active salt compound film on said topical site and said active salt compound disassociates into said polymer and said at least one active while said delivery system is in contact with said topical site such that said polymer remains thereon as a polymer film and said at least one active is delivered to said topical site in an absorbable form.
Claim 3
Dependent Claim
12 words
The delivery system of claim 1 wherein said polymer is a homopolymer.
Claim 4
Dependent Claim
26 words
The delivery system of claim 1 wherein said polymer is a copolymer of an ethylenically unsaturated carboxylic acid or cyclic anhydride thereof and a vinyl ether.
Claim 5
Dependent Claim
25 words
The delivery system of claim 1 wherein said polymer is a graft polymer, said graft polymer having at least one carboxylic acid moiety grafted thereto.
Claim 6
Dependent Claim
32 words
The delivery system of claim 1 where said active has an amine moiety capable of complexing with at least one carboxylic acid moiety of said polymer to form said active salt compound.
Claim 7
Dependent Claim
14 words
The delivery system of claim 1 which is in the form of a film.
Claim 8
Dependent Claim
28 words
The delivery system of claim 1 which is in a form selected from the group consisting of a gel, a solution, a lotion, a cream and an ointment.
Claim 9
Dependent Claim
14 words
The delivery system of claim 1 which is in the form of a patch.
Claim 10
Dependent Claim
14 words
The delivery system of claim 1 which is in the form of an aerosol.
Claim 11
Dependent Claim
14 words
The delivery system of claim 1 which is in the form of a suppository.
Claim 12
Dependent Claim
14 words
The delivery system of claim 1 which is in the form of a fiber.
Claim 13
Dependent Claim
14 words
The delivery system of claim 1 which is in the form of a rod.
Claim 14
Dependent Claim
13 words
The delivery system of claim 1 which is in the form of microspheres.
Claim 15
Independent Claim
210 words
A method for the preparation of a delivery system for use in administration of a pharmaceutically and, therapeutically effective amount of actives to a topical site of a subject, said method comprising: preparing an active salt compound by complexing (1) a carboxylic acid moiety-containing, biocompatible, film-forming polymer said carboxylic acid moiety-containing polymer being selected from the group consisting of polycarboxylic acid polymers and cyclic anhydride moiety containing polymers with (2) at least one active selected from the group consisting of pharmaceutical actives, therapeutic actives and a combination thereof and formulating said delivery system which comprises said active salt compound, wherein said at least one active is capable of complexing with at least one carboxylic acid moiety of said polymer to form said active salt compound, and wherein said active salt compound forms an active salt compound film on said topical site and said active salt compound disassociates into said polymer and said at least one active while said delivery system is in contact with said topical site such that said polymer remains thereon as a polymer film and said at least one active is delivered to said topical site in an absorbable form; which method comprises blending said active, said polymer, and a solvent and forming said active salt compound.
Claim 16
Independent Claim
210 words
A method for the preparation of a delivery system for use in administration of a pharmaceutically and, therapeutically effective amount of actives to a topical site of a subject, said method comprising: preparing an active salt compound by complexing (1) a carboxylic acid moiety-containing, biocompatible, film-forming polymer said carboxylic acid moiety-containing polymer being selected from the group consisting of polycarboxylic acid polymers and cyclic anhydride moiety containing polymers with (2) at least one active selected from the group consisting of pharmaceutical actives, therapeutic actives and a combination thereof and formulating said delivery system which comprises said active salt compound, wherein said at least one active is capable of complexing with at least one carboxylic acid moiety of said polymer to form said active salt compound, and wherein said active salt compound forms an active salt compound film on said topical site and said active salt compound disassociates into said polymer and said at least one active while said delivery system is in contact with said topical site such that said polymer remains thereon as a polymer film and said at least one active is delivered to said topical site in an absorbable form; which method comprises blending said active, said polymer, and a solvent and forming said active salt compound.
Claim 17
Dependent Claim
18 words
The method of claim 14 wherein said formulating step comprises blending a diluent with said active salt compound.
Claim 18
Dependent Claim
17 words
The method of claim 14 wherein said polymer is dissolved in a solvent before said complexing step.
Claim 19
Dependent Claim
15 words
The method of claim 14 wherein said active is dissolved in a solvent before blending.
Claim 20
Dependent Claim
38 words
A method for the topical administration of a pharmaceutical or therapeutic active to a subject, which comprises administering to said subject at a designated site, a pharmaceutically or therapeutically effective amount of the delivery system of claim 1.
Claim 21
Dependent Claim
14 words
The delivery system of claim 7 which is in the form of a solution.
References Cited (Backward Citations)
US4013820A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-03-04 | 1994-09-03 | 1995-03-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-04 | 1998-09-03 | 1999-03-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-04 | 2002-09-03 | 2003-03-05 | $7700.00 | Window Closed / Lapsed |