US5011920A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Disialofucoganglioside immunogen and fucoganglioside monosialosyl Lea II
Assignee: Fred Hutchinson Cancer Center
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Filing: 1989-05-05
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Granted: 1991-04-30
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Expires: 2009-05-05
Abstract
Abstract Disialosyl Lea (IV3NeuAcIII6NeuAcIII4FucLc4), a novel human cancer-associated fucoganglioside that is highly immunogenic. Also, a hybridoma cell line (ATCC No. HB 8861) secreting a monoclonal IgG3 antibody (FH7) directed to disialosyl Lea. The disialosyl Lea antigen was detected in various cancer tissues and their cell lines but was absent in various normal tissues and blood cells. Sera of patients with various cancers, particularly early cases of colonic and gastric cancers, showed an elevated disialosyl Lea antigen level, which subsequently decreased after surgical tumor removal.
Inventors
- 👤 Sen-itiroh Hakomori
- 👤 Yasuo Fukushi
- 👤 Edward D. Nudelman
- 👤 Steven B. Levery
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 13:51
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/02; C07H15/04; C07H15/10; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/3046; Y; Y10; Y10S; Y10S530/00; Y10S530/861
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
12 words
The substantially purified fucoganglioside disialosyl Le a which has the structure ##STR11##
Claim 2
Dependent Claim
12 words
The substantially purified fucoganglioside disialosyl Le a which has the structure ##STR11##
Claim 3
Dependent Claim
13 words
The substantially purified fucoganglioside monosialosyl Le a II which has the structure ##STR12##
Claim 4
Dependent Claim
13 words
The substantially purified fucoganglioside monosialosyl Le a II which has the structure ##STR12##
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-29 | 1994-10-29 | 1995-04-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-29 | 1998-10-29 | 1999-04-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-29 | 2002-10-29 | 2003-04-30 | $7700.00 | Window Closed / Lapsed |