US5028542A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Glucose measurement control reagent and method of making the same
Assignee: Roche Diabetes Care Inc
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Filing: 1990-02-07
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Granted: 1991-07-02
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Expires: 2010-02-07
Abstract
Abstract The invention relates to a non-serum based control reagent for glucose determination. Rather than using modified serum, the control reagent contains water, glucose, and the viscosity agent polystyrene sulphonate. The control reagent may also contain a buffer, preservatives, surfactants or surface active agents. A method of making the control reagent is also disclosed.
Inventors
- 👤 Jim Kennamer
- 👤 Diane Storhoff
- 👤 Roger Bontrager
- 👤 David Tabb
- 👤 Arthur Usmani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 22:34
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/54; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N2496/00; G01N2496/25; G01N33/66; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104998; Y10T436/108331; Y10T436/14; Y10T436/142222; Y10T436/143333; Y10T436/144444
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
26 words
Serum-free control reagent for glucose determination comprising a mixture of: (i) a predetermined amount of glucose, (ii) water, and (iii) polystyrene sulphonate or a salt thereof.
Claim 2
Dependent Claim
26 words
Serum-free control reagent for glucose determination comprising a mixture of: (i) a predetermined amount of glucose, (ii) water, and (iii) polystyrene sulphonate or a salt thereof.
Claim 3
Dependent Claim
28 words
Serum-free control reagent of claim 1, wherein said polystyrene sulphonate is present in an amount ranging from about 0.5 to about 60 weight percent of said control reagent.
Claim 4
Dependent Claim
28 words
Serum-free control reagent of claim 2, wherein said polystyrene sulphonate is present in an amount ranging from about 20 to about 30 weight percent of said control reagent.
Claim 5
Dependent Claim
28 words
Serum-free control reagent of claim 1, wherein said polystyrene sulphonate is present in an amount ranging from about 0.5 to about 40 weight percent of said control reagent.
Claim 6
Dependent Claim
21 words
Serum-free control reagent of claim 1, wherein said polystyrene sulphonate has an atomic weight of from about 5000 to about 6,000,000.
Claim 7
Dependent Claim
21 words
Serum-free control reagent of claim 5, wherein said polystyrene sulphonate has an atomic weight of from about 35,000 to about 750,000.
Claim 8
Dependent Claim
21 words
Serum-free control reagent of claim 6, wherein said polystyrene sulphonate has an atomic weight of from about 70,000 to about 500,000.
Claim 9
Dependent Claim
10 words
Serum-free control reagent of claim 1, further comprising a buffer.
Claim 10
Dependent Claim
32 words
Serum-free control reagent of claim 8, wherein said buffer is selected from the group consisting of 4-(2-hydroxy ethyl-1-piperazene-ethane sulphonic acid), 2-(N-cyclohexylamino)ethane sulphonic acid, 3-(N-morpholino)propane sulphonic acid, 2-(N-morpholino)ethane sulphonic acid, and 3-(cyclohexylamino)-1-1-propane-sulphonic acid.
Claim 11
Dependent Claim
12 words
Serum-free control reagent of claim 1, further comprising at least one preservative.
Claim 12
Dependent Claim
19 words
Serum-free control reagent of claim 10 wherein said preservative is imidazolidinyl urea, methylparaben, methanol(((2-(dihydro-5-methyl-3(2H)-oxazolyl)-1-methylethyloxy)methoxy) methoxy), phenoxyethanol, or gentamyacin sulphate.
Claim 13
Dependent Claim
10 words
Serum-free control reagent of claim 1, further comprising a surfactant.
Claim 14
Dependent Claim
11 words
Serum-free control reagent of claim 1, further comprising an ionic salt.
Claim 15
Dependent Claim
14 words
Serum-free control reagent of claim 1, further comprising a colored or color forming compound.
Claim 16
Dependent Claim
34 words
Serum-free control reagent for glucose determination consisting essentially of a mixture of: (i) glucose, (ii) water, (iii) polystyrene sulphonate or a salt thereof, (iv) a preservative, and (v) a surfactant or surface active agent.
Claim 17
Dependent Claim
34 words
Serum-free control reagent for glucose determination consisting essentially of a mixture of: (i) glucose, (ii) water, (iii) polystyrene sulphonate or a salt thereof, (iv) a preservative, and (v) a surfactant or surface active agent.
Claim 18
Dependent Claim
20 words
Lyophilized, serum-free control reagent comprising a mixture of a predetermined amount of glucose, and a polystyrene sulphonate or salt thereof.
Claim 19
Dependent Claim
20 words
Lyophilized, serum-free control reagent comprising a mixture of a predetermined amount of glucose, and a polystyrene sulphonate or salt thereof.
Claim 20
Dependent Claim
23 words
Process for making a serum free glucose control reagent comprising mixing a predetermined amount of glucose with a polystyrene sulphonate or salt thereof.
Claim 21
Dependent Claim
23 words
Process for making a serum free glucose control reagent comprising mixing a predetermined amount of glucose with a polystyrene sulphonate or salt thereof.
Claim 22
Dependent Claim
14 words
Process of claim 17, further comprising mixing water with said glucose and polystyrene sulphonate.
Claim 23
Dependent Claim
45 words
Process of claim 17, further comprising mixing at least one material selected from the group consisting of a buffer, a preservative, a surfactant, an inorganic salt and a colored or color forming compound to said predetermined amount of glucose and polystyrene sulphonate or salt thereof.
References Cited (Backward Citations)
US3682835A
Cited
US3920580A
Cited
US4517301A
Cited
US4684615A
Cited
US4729959A
Cited
US4731330A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-01 | 1994-12-31 | 1995-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-01 | 1998-12-31 | 1999-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-01 | 2002-12-31 | 2003-07-02 | $7700.00 | Window Closed / Lapsed |