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US5055404A Expired / Lapsed US ⏱️ 0.0 years remaining

Monoclonal antibody specifically reactive to surface of human prostatic epithelial cells

Assignee: Individual
•
Filing: 1989-08-07
•
Granted: 1991-10-08
•
Expires: 2009-08-07
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Abstract

Abstract Monoclonal antibodies Pes-1, Pes-2, Pes-3 and Pes-4 which are respectively produced by hybridomas hPro-1.10G (FERM BP-1986), hPro-4.10H (FERM BP-2634), hPro-5.10F and hPro-1.5F specifically bind to the surface of human prostatic epithelial cells. They do not bind to any of many other normal or tumor tissues. The monoclonal antibodies are prepared by immunizing an animal with pieces of epithelial tissue from human prostate as an antigen, fusing antibody-producing cells of the animal with myeloma cells, selecting a hybridoma which produces the antibody, cultivating the hybridoma and recovering the antibody. The monoclonal antibodies have utility for histological examination for metastatic nests in prostatic cancer, preoperative examination in prostatic cancer, diagnosis of prostatic cancer.

Inventors

  • 👤 Masamichi Ueda
  • 👤 Tatsuhiro Yoshiki

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 12:44
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1024; A61K51/1045; A61K51/106; A61P; A61P35/00; C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/3038; A61K2123/00

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 30 words
A monoclonal antibody Pes-1 which is produced by hybridoma hPro-1.10G having the Fermentation Research Institute accession number FERM BP-1986 and specifically binds to the surface of human prostatic epithelial cells.
Claim 2
Dependent Claim 30 words
A monoclonal antibody Pes-1 which is produced by hybridoma hPro-1.10G having the Fermentation Research Institute accession number FERM BP-1986 and specifically binds to the surface of human prostatic epithelial cells.
Claim 3
Dependent Claim 30 words
A monoclonal antibody Pes-2 which is produced by hybridoma hPro-4.10H having the Fermentation Research Institute accession number FERM BP-2634 and specifically binds to the surface of human prostatic epithelial cells.
Claim 4
Dependent Claim 30 words
A monoclonal antibody Pes-2 which is produced by hybridoma hPro-4.10H having the Fermentation Research Institute accession number FERM BP-2634 and specifically binds to the surface of human prostatic epithelial cells.
Claim 5
Dependent Claim 12 words
A hybridoma hPro-1.10G having the Fermentation Research Institute accession number FERM BP-1986.
Claim 6
Dependent Claim 12 words
A hybridoma hPro-1.10G having the Fermentation Research Institute accession number FERM BP-1986.
Claim 7
Dependent Claim 12 words
A hybridoma hPro-4.10H having the Fermentation Research Institute accession number FERM BP-2634.
Claim 8
Dependent Claim 12 words
A hybridoma hPro-4.10H having the Fermentation Research Institute accession number FERM BP-2634.

References Cited (Backward Citations)

US4446122A Cited
GB2139645A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1994-10-07 1995-04-08 1995-10-08 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1998-10-07 1999-04-08 1999-10-08 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2002-10-07 2003-04-08 2003-10-08 $7700.00 Window Closed / Lapsed

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