US5071965A
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US
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Novel tc-99m complexes
Assignee: Mallinckrodt Inc
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Filing: 1989-02-24
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Granted: 1991-12-10
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Expires: 2009-02-24
Abstract
Abstract Complexes useful as radiopharmaceutical imaging agents comprise technetium bonded to a ligand which generally can be described by the formula: ##STR1## wherein Z is N, C, B or P; the three Y groups can be the same or different, each characterized by the general formula ##STR2## and R 1 , R 2 , R 3 , R 4 , W, and X are further defined herein.
Inventors
- 👤 T. Jeffrey Dunn
- 👤 Dennis Nosco
- 👤 Steven Woulfe
- 👤 Richard Dean
- 👤 Dennis Wester
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 04:01
CPC Classifications
C; C07; C07F; C07F13/00; C07F13/005; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; C07C; C07C211/00; C07C211/01; C07C211/02; C07C211/13; C07C215/00; C07C215/46; C07C215/48; C07C215/50; C07C217/00; C07C217/02; C07C217/04; C07C217/42; C07C251/00; C07C251/02; C07C251/04; C07C251/06; C07C251/08; C07C251/24; C07F9/00; C07F9/02; C07F9/28; C07F9/50; C07F9/5013; A61K2123/00
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
111 words
A complex useful as a radiopharmaceutical imaging agent comprising technetium in the + 4 oxidation state bonded to a ligand having the formula: ##STR72## wherein Z is C, and the three Y groups are characterized by the general formula. ##STR73## wherein R 1 and R 2 taken together with the carbon atoms to which they are directly attached, form an aryl group, R 3 is H, R 4 is CH 2 OCH 2 CH 2 CH 3 , each of R 5 , R 6 , R 7 , and R 8 is H and W is CH 2 such that y has the general formula ##STR74## wherein X is OH.
Claim 2
Dependent Claim
111 words
A complex useful as a radiopharmaceutical imaging agent comprising technetium in the + 4 oxidation state bonded to a ligand having the formula: ##STR72## wherein Z is C, and the three Y groups are characterized by the general formula. ##STR73## wherein R 1 and R 2 taken together with the carbon atoms to which they are directly attached, form an aryl group, R 3 is H, R 4 is CH 2 OCH 2 CH 2 CH 3 , each of R 5 , R 6 , R 7 , and R 8 is H and W is CH 2 such that y has the general formula ##STR74## wherein X is OH.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-12-09 | 1995-06-10 | 1995-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-09 | 1999-06-10 | 1999-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-09 | 2003-06-10 | 2003-12-10 | $7700.00 | Window Closed / Lapsed |