US5075127A
Expired / Lapsed
US
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Sensor with overcoating and process for making same
Assignee: Terumo Cardiovascular Systems Corp
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Filing: 1990-03-12
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Granted: 1991-12-24
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Expires: 2010-03-12
Abstract
Abstract A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.
Inventors
- 👤 Masao Yafuso
- 👤 Henry K. Hui
- 👤 Cheng F. Yan
- 👤 William W. Miller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:15
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/1459; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N31/00; G01N31/22; G01N31/223; G01N2021/6434; G01N2021/7706; G01N2021/772; G01N21/78; G01N21/81
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
69 words
A process for forming an overcoating on a sensing element, comprising the steps of: contacting a sensing element with a composition comprising a solvent and a soluble cellulosic coating material or a soluble precursor of said cellulosic coating material to form a composition coated sensing element; and treating said composition coated sensing element so as to cross-link said cellulosic coating material and form said overcoating on said sensing element.
Claim 2
Dependent Claim
69 words
A process for forming an overcoating on a sensing element, comprising the steps of: contacting a sensing element with a composition comprising a solvent and a soluble cellulosic coating material or a soluble precursor of said cellulosic coating material to form a composition coated sensing element; and treating said composition coated sensing element so as to cross-link said cellulosic coating material and form said overcoating on said sensing element.
Claim 3
Dependent Claim
16 words
The process of claim 1 wherein said composition and thus said overcoating includes an opaque agent.
Claim 4
Dependent Claim
39 words
The process of claim 1 further comprising the step of contacting said sensing element with an opaque agent to at least partially coat said sensing element with said opaque agent prior to contacting said sensing element with said composition.
Claim 5
Dependent Claim
30 words
The process of claim 2 wherein said composition further includes an additional component in an amount effective to enhance the permeability of said overcoating to an analyte to be sensed.
Claim 6
Dependent Claim
20 words
The process of claim 1 wherein said composition includes acylated cellulose as a soluble precursor of said cellulosic coating material.
Claim 7
Dependent Claim
31 words
The process of claim 1 wherein said treating step acts to both hydrolyze the cellulosic material or precursor and cross-link the hydrolyzed material to form said cross-linked cellulosic coating material-containing overcoating.
Claim 8
Dependent Claim
19 words
The process of claim 1 which further comprises the step of forming a blood compatible film on said overcoating.
Claim 9
Dependent Claim
15 words
The process of claim 2 wherein said opaque agent is a dye adsorptive opaque agent.
Claim 10
Dependent Claim
14 words
The process of claim 8 wherein said dye adsorptive opaque agent is carbon black.
Claim 11
Dependent Claim
22 words
The process of claim 4 wherein said additional component is substantially removed from said composition coated sensing element during said treating step.
Claim 12
Dependent Claim
40 words
The process of claim 10 wherein said additional component is water soluble and said treating step comprises contacting said sensing element containing said cross-linked cellulosic coating material with an aqueous liquid at conditions effective to substantially remove said additional component.
Claim 13
Dependent Claim
65 words
The process of claim 11 wherein said treating step comprises both contacting said composition coated sensing element at conditions effective to hydrolyze at least a portion of said cellulosic coating material on said sensing element, and contacting said sensing element containing said hydrolyzed cellulosic material with at least one cross-linking agent at conditions effective to form said cross-linked cellulosic coating material on said sensing element.
Claim 14
Dependent Claim
65 words
The process of claim 1 wherein said treating step comprises both contacting said composition coated sensing element at conditions effective to hydrolyze at least a portion of said cellulosic coating material on said sensing element, and contacting said sensing element containing said hydrolyzed cellulosic material with at least one cross-linking agent at conditions effective to form said cross-linked cellulosic coating material on said sensing element.
Claim 15
Dependent Claim
38 words
The process of claim 13 wherein said cross-linking agent is selected from the group consisting of ethylene glycol diglycidyl ether, butanediol diglycidyl ether, epichlorohydrine, 1,3 butadiene diepoxide, 1,2,7,8-diepoxy octane, 1,2,5,6-diepoxy cyclooctane, diethylene glycol diglycidyl ether, and mixtures thereof.
Claim 16
Dependent Claim
14 words
The process of claim 13 wherein said cross-linking agent is ethylene glycol diglycidyl ether.
Claim 17
Dependent Claim
36 words
The process of claim 1 wherein said composition includes a soluble precursor of said cellulosic coating material, said precursor comprising acylated cellulose wherein the acyl groups contain about 1 to about 10 carbon atoms per molecule.
Claim 18
Dependent Claim
24 words
The process of claim 1 wherein said composition includes a soluble precursor of said cellulosic coating material and wherein said precursor is cellulose acetate.
Claim 19
Dependent Claim
15 words
The process of claim 2 wherein said opaque agent is a dye non-adsorptive opaque agent.
Claim 20
Dependent Claim
25 words
The process of claim 18 wherein said dye non-adsorptive opaque agent is selected from the group consisting of ferric oxide, metallic phthalocyanines, and mixtures thereof.
Claim 21
Dependent Claim
45 words
The process of claim 19 wherein said dye non-adsorptive opaque agent is a metallic phthalocyanine and wherein the metallic portion of said phthalocyanine is selected from the group of metals consisting of copper, iron, cobalt, lithium, magnesium, nickel, zinc, vanadium, manganese, sodium, and mixtures thereof.
References Cited (Backward Citations)
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