US5076911A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Centrifugation chamber having an interface detection surface
Assignee: Fenwal Inc
•
Filing: 1991-03-27
•
Granted: 1991-12-31
•
Expires: 2011-03-27
Abstract
Abstract A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis. The platelet rich plasma is separated from the residual red blood cells in a first part. The platelet rich plasma flows into the second part and is separated into platelet poor plasma and platelets. The platelet poor plasma can be drawn off and returned to a donor or collected. The platelet concentrate can then be accumulated in a separate container.
Inventors
- 👤 Richard J. Brown
- 👤 Sidney Smith
- 👤 David E. Cerny
- 👤 John T. Foley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:33
CPC Classifications
B; B04; B04B; B04B5/00; B04B5/04; B04B5/0442; A; A61; A61M; A61M1/00; A61M1/14; A61M1/30; A61M1/301; A61M1/302; A61M1/303; A61M1/305; A61M1/308; A61M1/36; A61M1/3601; A61M1/3603; A61M1/3693; A61M1/3696; A61M1/02; A61M1/025; A61M2205/00; A61M2205/33; A61M2205/3306; A61M2205/331; A61M2205/3331; A61M2205/3344; A61M2205/3351; A61M2205/3355; A61M2205/3379; A61M2205/3393; B04B2005/045
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
306 words
A centrifugation chamber for positioning within a field rotating about an axis comprising first and second side walls defining a generally elongated processing chamber having oppositely spaced ends, the first side wall, when positioned within the rotating field, being adapted to be disposed closer to the rotational axis than the second side wall and defining within the processing chamber a low-g force region adjacent the first side wall and a high-g force region adjacent the second side wall, a source inlet port at one end of the chamber for conveying source fluid to be processed into the chamber for flow toward the opposite end of the chamber while being separated in the rotating field into a first constituent that flows along the first side wall in the low-g force region of the chamber, a second constituent that flows along the second side wall in the high-g force region of the chamber, and an interface that flows between the first and second constituents in an intermediate-g force region between the first and second side walls, interior wall means extending into the intermediate-g force region of the processing chamber from one of the side walls, the interior wall means being oriented at a non-perpendicular angle relative to the one side wall in the direction of source fluid flow for directing fluid flow away from the one side wall toward the other side wall to expose the interface upon the interior wall means for detection through a side wall of the processing chamber, and at least one of the side walls includes a material in the region of the interior wall means that is transmissive to a preselected type of sensing energy for transmitting the sensing energy from outside the processing chamber upon the interior wall means to detect the location of the interface upon the interior wall means.
Claim 2
Dependent Claim
306 words
A centrifugation chamber for positioning within a field rotating about an axis comprising first and second side walls defining a generally elongated processing chamber having oppositely spaced ends, the first side wall, when positioned within the rotating field, being adapted to be disposed closer to the rotational axis than the second side wall and defining within the processing chamber a low-g force region adjacent the first side wall and a high-g force region adjacent the second side wall, a source inlet port at one end of the chamber for conveying source fluid to be processed into the chamber for flow toward the opposite end of the chamber while being separated in the rotating field into a first constituent that flows along the first side wall in the low-g force region of the chamber, a second constituent that flows along the second side wall in the high-g force region of the chamber, and an interface that flows between the first and second constituents in an intermediate-g force region between the first and second side walls, interior wall means extending into the intermediate-g force region of the processing chamber from one of the side walls, the interior wall means being oriented at a non-perpendicular angle relative to the one side wall in the direction of source fluid flow for directing fluid flow away from the one side wall toward the other side wall to expose the interface upon the interior wall means for detection through a side wall of the processing chamber, and at least one of the side walls includes a material in the region of the interior wall means that is transmissive to a preselected type of sensing energy for transmitting the sensing energy from outside the processing chamber upon the interior wall means to detect the location of the interface upon the interior wall means.
Claim 3
Dependent Claim
16 words
A chamber according to claim 1 wherein the side wall material is transmissive to radiant energy.
Claim 4
Dependent Claim
22 words
A chamber according to claim 1 wherein the interior wall means includes a material that is also transmissive to the sensing energy.
Claim 5
Dependent Claim
17 words
A chamber according to claim 3 wherein the interior wall means material is transmissive to radiant energy.
Claim 6
Dependent Claim
46 words
A chamber according to claim 3 wherein both side walls are transmissive in the region of the transmissive interior wall means to transmit the sensing energy in a path that enters one side wall, passes through the interior wall means, and exits the other side wall.
Claim 7
Dependent Claim
23 words
A chamber according to claim 5 wherein the material of the side walls and the interior wall means is transmissive to radiant energy.
Claim 8
Dependent Claim
50 words
A chamber according to claim 1 and further including a first outlet port adjacent the first side wall for collecting separated constituent in the low-g region of the chamber, and a second outlet port adjacent the second side wall for collecting separated constituent in the high-g region of the chamber.
Claim 9
Dependent Claim
36 words
A chamber according to claim 7 wherein at least one of the first and second outlet ports is located, relative to the direction of source fluid flow, downstream of the region of the interior wall means.
Claim 10
Dependent Claim
33 words
A chamber according to claim 7 wherein both the first and second outlet ports are located, relative to the direction of source fluid flow, downstream of the region of the interior wall means.
Claim 11
Dependent Claim
57 words
A chamber according to claim 7 wherein one of the outlet ports is located, relative to the direction of source fluid flow, downstream of the region of the interior wall means, and wherein the other outlet port is located, relative to the direction of the source fluid flow, upstream of the region of the interior wall means.
Claim 12
Dependent Claim
38 words
A chamber according to claim 10 wherein the first outlet port is located downstream of the region of the interior wall means, and the second outlet port is located upstream of the region of the interior wall means.
Claim 13
Dependent Claim
56 words
A chamber according to claim 11 and further including ramp means on a portion of the second side wall extending toward the second outlet port for urging constituent separated in the high-g region to flow along the ramp means toward the second outlet port in a direction opposite to the flow direction of source fluid flow.
Claim 14
Dependent Claim
44 words
A chamber according to claim 12 wherein the ramp means joins the interior wall means adjacent the second side wall and extends therefrom along the second side wall in a direction opposite to the flow of the source fluid toward the second outlet port.
Claim 15
Dependent Claim
30 words
A chamber according to claim 11 or 12 or 13 wherein the inlet source port and the second outlet port are located at the same end of the processing chamber.
Claim 16
Dependent Claim
38 words
A chamber according to claim 11 or 12 or 13 wherein the inlet source port enters the processing chamber at a location that is adapted to be closer to the axis of rotation than the second outlet port.
Claim 17
Dependent Claim
34 words
A chamber according to claim 15 wherein the inlet source port enters the processing chamber at a location that is adapted to be farther from the axis of rotation than the first outlet port.
Claim 18
Dependent Claim
21 words
A chamber according to claim 7 wherein one of the first and second outlet ports communicates with a second processing chamber.
Claim 19
Dependent Claim
347 words
A centrifugation chamber for positioning within a field rotating about an axis comprising first and second side walls defining a generally elongated processing chamber having oppositely spaced ends, the first side wall, when positioned within the rotating field, being adapted to be disposed closer to the rotational axis than the second side wall and defining within the processing chamber a low-g force region adjacent the first side wall and a high-g force region adjacent the second side wall, a source inlet port at one end of the chamber for conveying source fluid to be processed into the chamber for flow toward the opposite end of the chamber while being separated in the rotating field into a first constituent that flows along the first side wall in the low-g force region of the chamber, a second constituent that flows along the second side wall in the high-g force region of the chamber, and an interface that flows between the first and second constituents in an intermediate-g force region between the first and second side walls, a first outlet port adjacent the first side wall for collecting separated constituent from the low-g region of the chamber, a second outlet port adjacent the second side wall for collecting separated constituent from the high-g region of the chamber, interior wall means extending into the intermediate-g force region of the processing chamber from one of the side walls, the interior wall means being oriented at a non-perpendicular angle relative to the one side wall in the direction of source fluid flow for directing fluid flow away from the one side wall toward the other side wall to expose the interface upon the interior wall means for detection through a side wall of the processing chamber, and the interior wall means and both side walls in the region of the interior wall means include a material that is transmissive to a preselected type of sensing energy for transmitting the sensing energy from outside the processing chamber through the interior wall means to detect the location of the interface upon the interior wall means.
Claim 20
Dependent Claim
347 words
A centrifugation chamber for positioning within a field rotating about an axis comprising first and second side walls defining a generally elongated processing chamber having oppositely spaced ends, the first side wall, when positioned within the rotating field, being adapted to be disposed closer to the rotational axis than the second side wall and defining within the processing chamber a low-g force region adjacent the first side wall and a high-g force region adjacent the second side wall, a source inlet port at one end of the chamber for conveying source fluid to be processed into the chamber for flow toward the opposite end of the chamber while being separated in the rotating field into a first constituent that flows along the first side wall in the low-g force region of the chamber, a second constituent that flows along the second side wall in the high-g force region of the chamber, and an interface that flows between the first and second constituents in an intermediate-g force region between the first and second side walls, a first outlet port adjacent the first side wall for collecting separated constituent from the low-g region of the chamber, a second outlet port adjacent the second side wall for collecting separated constituent from the high-g region of the chamber, interior wall means extending into the intermediate-g force region of the processing chamber from one of the side walls, the interior wall means being oriented at a non-perpendicular angle relative to the one side wall in the direction of source fluid flow for directing fluid flow away from the one side wall toward the other side wall to expose the interface upon the interior wall means for detection through a side wall of the processing chamber, and the interior wall means and both side walls in the region of the interior wall means include a material that is transmissive to a preselected type of sensing energy for transmitting the sensing energy from outside the processing chamber through the interior wall means to detect the location of the interface upon the interior wall means.
Claim 21
Dependent Claim
14 words
A chamber according to claim 18 wherein the material is transmissive to radiant energy.
Claim 22
Dependent Claim
38 words
A chamber according to claim 18 or 19 wherein at least one of the first and second outlet ports is located, relative to the direction of source fluid flow, downstream of the region of the interior wall means.
Claim 23
Dependent Claim
33 words
A chamber according to claim 20 wherein both the first and second outlet ports are located, relative to the direction of source fluid flow, downstream of the region of the interior wall means.
Claim 24
Dependent Claim
57 words
A chamber according to claim 20 wherein one of the outlet ports is located, relative to the direction of source fluid flow, downstream of the region of the interior wall means, and wherein the other outlet port is located, relative to the direction of the source fluid flow, upstream of the region of the interior wall means.
Claim 25
Dependent Claim
38 words
A chamber according to claim 22 wherein the first outlet port is located downstream of the region of the interior wall means, and the second outlet port is located upstream of the region of the interior wall means.
Claim 26
Dependent Claim
23 words
A chamber according to claim 18 or 19 wherein one of the first and second outlet ports communicated with a second processing chamber.
Claim 27
Dependent Claim
434 words
A centrifugation chamber for positioning within a field rotating about an axis comprising first and second side walls defining a generally elongated processing chamber having oppositely spaced ends, the first side wall, when positioned within the rotating field, being adapted to be disposed closer to the rotational axis than the second side wall and defining within the processing chamber a low-g force region adjacent the first side wall and a high-g force region adjacent the second side wall, a source inlet port at one end of the chamber for conveying source fluid to be processed into the chamber for flow toward the opposite end of the chamber while being separated in the rotating field into a first constituent that flows along the first side wall in the low-g force region of the chamber, a second constituent that flows along the second side wall in the high-g force region of the chamber, and an interface that flows between the first and second constituents in an intermediate-g force region between the first and second side walls, interior wall means extending into the intermediate-g force region of the processing chamber from one of the side walls, the interior wall means being oriented at a non-perpendicular angle relative to the one side wall in the direction of source fluid flow for directing fluid flow away from the one side wall toward the other side wall to expose the interface upon the interior wall means for detection through a side wall of the processing chamber, the interior wall means and both side walls in the region of the interior wall means include a material that is transmissive to a preselected type of sensing energy for transmitting the sensing energy from outside the processing chamber through the interior wall means to detect the location of the interface upon the interior wall means, a first outlet port adjacent the first side wall for collecting separated constituent from the low-g region of the chamber, the first outlet port being located downstream of the region of the interior wall means, a second outlet port adjacent the second side wall for collecting separated constituent from the high-g region of the chamber, the second outlet port being located upstream of the region of the interior wall means, and ramp means joined to the interior wall means and extending therefrom along the second side wall toward the second outlet port for urging constituent separated in the high-g region to flow along the ramp means from the interior wall means toward the second outlet port in a direction opposite to the flow direction of source fluid flow.
Claim 28
Dependent Claim
434 words
A centrifugation chamber for positioning within a field rotating about an axis comprising first and second side walls defining a generally elongated processing chamber having oppositely spaced ends, the first side wall, when positioned within the rotating field, being adapted to be disposed closer to the rotational axis than the second side wall and defining within the processing chamber a low-g force region adjacent the first side wall and a high-g force region adjacent the second side wall, a source inlet port at one end of the chamber for conveying source fluid to be processed into the chamber for flow toward the opposite end of the chamber while being separated in the rotating field into a first constituent that flows along the first side wall in the low-g force region of the chamber, a second constituent that flows along the second side wall in the high-g force region of the chamber, and an interface that flows between the first and second constituents in an intermediate-g force region between the first and second side walls, interior wall means extending into the intermediate-g force region of the processing chamber from one of the side walls, the interior wall means being oriented at a non-perpendicular angle relative to the one side wall in the direction of source fluid flow for directing fluid flow away from the one side wall toward the other side wall to expose the interface upon the interior wall means for detection through a side wall of the processing chamber, the interior wall means and both side walls in the region of the interior wall means include a material that is transmissive to a preselected type of sensing energy for transmitting the sensing energy from outside the processing chamber through the interior wall means to detect the location of the interface upon the interior wall means, a first outlet port adjacent the first side wall for collecting separated constituent from the low-g region of the chamber, the first outlet port being located downstream of the region of the interior wall means, a second outlet port adjacent the second side wall for collecting separated constituent from the high-g region of the chamber, the second outlet port being located upstream of the region of the interior wall means, and ramp means joined to the interior wall means and extending therefrom along the second side wall toward the second outlet port for urging constituent separated in the high-g region to flow along the ramp means from the interior wall means toward the second outlet port in a direction opposite to the flow direction of source fluid flow.
Claim 29
Dependent Claim
14 words
A chamber according to claim 25 wherein the material is transmissive to radiant energy.
Claim 30
Dependent Claim
28 words
A chamber according to claim 25 or 26 wherein the inlet source port and the second outlet port are located at the same end of the processing chamber.
Claim 31
Dependent Claim
34 words
A chamber according to claim 27 wherein the inlet source port enters the processing chamber at a location that is adapted to be closer to the axis of rotation than the second outlet port.
Claim 32
Dependent Claim
34 words
A chamber according to claim 27 wherein the inlet source port enters the processing chamber at a location that is adapted to be farther from the axis of rotation than the first outlet port.
Claim 33
Dependent Claim
21 words
A chamber according to claim 27 wherein one of the first and second outlet ports communicates with a second processing chamber.
Claim 34
Dependent Claim
258 words
A centrifugation chamber for positioning within a field rotating about an axis comprising first and second side walls defining a processing chamber, the first side wall, when positioned within the rotating field, being adapted to be disposed closer to the rotational axis than the second side wall and defining within the processing chamber a low-g force region adjacent the first side wall and a high-g force region adjacent the second side wall, a source inlet port in the chamber for conveying source fluid to be processed into the chamber for separation in the rotating field into a first constituent that separates out along the first side wall in the low-g force region of the chamber, a second constituent that separates out along the second side wall in the high-g force region of the chamber, and an interface formed between the first and second constituents in an intermediate-g force region between the first and second side walls, interior wall means that extends into the intermediate-g force region of the processing chamber from one side wall toward the other side wall for directing fluid flow to expose the interface upon the interior wall means for detection through a side wall of the processing chamber, and at least one of the side walls includes a material in the region of the interior wall means that is transmissive to a preselected type of sensing energy for transmitting the sensing energy from outside the processing chamber upon the interior wall means to detect the location of the interface upon the interior wall means.
Claim 35
Dependent Claim
258 words
A centrifugation chamber for positioning within a field rotating about an axis comprising first and second side walls defining a processing chamber, the first side wall, when positioned within the rotating field, being adapted to be disposed closer to the rotational axis than the second side wall and defining within the processing chamber a low-g force region adjacent the first side wall and a high-g force region adjacent the second side wall, a source inlet port in the chamber for conveying source fluid to be processed into the chamber for separation in the rotating field into a first constituent that separates out along the first side wall in the low-g force region of the chamber, a second constituent that separates out along the second side wall in the high-g force region of the chamber, and an interface formed between the first and second constituents in an intermediate-g force region between the first and second side walls, interior wall means that extends into the intermediate-g force region of the processing chamber from one side wall toward the other side wall for directing fluid flow to expose the interface upon the interior wall means for detection through a side wall of the processing chamber, and at least one of the side walls includes a material in the region of the interior wall means that is transmissive to a preselected type of sensing energy for transmitting the sensing energy from outside the processing chamber upon the interior wall means to detect the location of the interface upon the interior wall means.
Claim 36
Dependent Claim
16 words
A chamber according to claim 31 wherein the side wall material is transmissive to radiant energy.
Claim 37
Dependent Claim
22 words
A chamber according to claim 31 wherein the interior wall means includes a material that is also transmissive to the sensing energy.
Claim 38
Dependent Claim
17 words
A chamber according to claim 33 wherein the interior wall means material is transmissive to radiant energy.
Claim 39
Dependent Claim
46 words
A chamber according to claim 33 wherein both side walls are transmissive in the region of the transmissive interior wall means to transmit the sensing energy in a path that enters one side wall, passes through the interior wall means, and exits the other side wall.
Claim 40
Dependent Claim
23 words
A chamber according to claim 35 wherein the material of the side walls and the interior wall means is transmissive to radiant energy.
Claim 41
Dependent Claim
28 words
A chamber according to claim 31 and further including an outlet port adjacent the first side wall for collecting separated constituent in the low-g region of the chamber.
Claim 42
Dependent Claim
30 words
A chamber according to claim 31 or 37 and further including an outlet port adjacent the second side wall for collecting separated constituent in the high-g region of the chamber.
Claim 43
Dependent Claim
84 words
A chamber according to claim 31 and further including a first outlet port adjacent the first side wall for collecting separated constituent in the low-g region of the chamber, a second outlet port adjacent the second side wall for collecting separated constituent in the high-g region of the chamber, and at least one of the first and second outlet ports is located, relative to the direction of source fluid flowing through the inlet source port, downstream of the region of the interior wall means.
Claim 44
Dependent Claim
33 words
A chamber according to claim 39 wherein both the first and second outlet ports are located, relative to the direction of source fluid flow, downstream of the region of the interior wall means.
Claim 45
Dependent Claim
57 words
A chamber according to claim 39 wherein one of the outlet ports is located, relative to the direction of source fluid flow, downstream of the region of the interior wall means, and wherein the other outlet port is located, relative to the direction of the source fluid flow, upstream of the region of the interior wall means.
Claim 46
Dependent Claim
38 words
A chamber according to claim 41 wherein the fluid outlet port is located downstream of the region of the interior wall means, and the second outlet port is located upstream of the region of the interior wall means.
Claim 47
Dependent Claim
48 words
A chamber according to claim 31 and further including an outlet port adjacent the second side wall for collecting separated constituent in the high-g region of the chamber, and wherein the inlet source port and the outlet port are located adjacent to each other in the processing chamber.
Claim 48
Dependent Claim
33 words
A chamber according to claim 43 wherein the inlet source port enters the processing chamber at a location that is adapted to be closer to the axis of rotation than the outlet port.
Claim 49
Dependent Claim
91 words
A chamber according to claim 31 and further including a first outlet port adjacent the first side wall for collecting separated constituent in the low-g region of the chamber, a second outlet port adjacent the second side wall for collecting separated constituent in the high-g region of the chamber, and wherein the inlet source port enters the processing chamber at a location that is adapted to be farther from the axis of rotation than the first outlet port while being closer to the axis of rotation that the second outlet port.
Claim 50
Dependent Claim
31 words
A chamber according to claim 31 and further including an outlet port that is located adjacent one of the first and second sidewalls and that communicates with a second processing chamber.
Claim 51
Dependent Claim
106 words
A chamber according to claim 31 and further including an outlet port adjacent the second side wall for collecting separated constituent in the high-g region of the chamber, the inlet source port and the outlet port being located adjacent to each other in the processing chamber, and ramp means joined to the interior wall means and extending therefrom along the second side wall toward the outlet port for urging constituent separated in the high-g region to flow along the ramp means from the interior wall means toward the outlet port in a direction opposite to the flow direction of source fluid through the inlet source port.
Claim 52
Dependent Claim
33 words
A chamber according to claim 47 wherein the inlet source port enters the processing chamber at a location that is adapted to be closer to the axis of rotation than the outlet port.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-30 | 1995-07-01 | 1995-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-30 | 1999-07-01 | 1999-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-30 | 2003-07-01 | 2003-12-31 | $7700.00 | Window Closed / Lapsed |