US5081042A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ionic component sensor and method for making and using same
Assignee: Terumo Cardiovascular Systems Corp
•
Filing: 1990-03-20
•
Granted: 1992-01-14
•
Expires: 2010-03-20
Abstract
Abstract A composition of matter useful in a sensor for sensing the concentration of an ionic component a medium is disclosed. This composition comprises a first material including a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, and a first matrix material, and a second material which includes a second matrix material which is compatible with the first matrix material, and an opague agent in an amount sufficient to render the second material effectively opaque. The first material and the second material are partially intermingled. Apparatus including such composition of matter and methods for making and using such compositions of matter are also disclosed.
Inventors
- 👤 Masao Yafuso
- 👤 Chong F. Yan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 10:08
CPC Classifications
G; G01; G01N; G01N31/00; G01N31/22; G01N31/221; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N2021/6434; G01N21/75; G01N21/77; G01N21/7703; G01N2021/7706; G01N2021/772; G01N2021/7769; G01N2021/7786
Claims Analysis
Total Claims: 47
Claim 1
Independent Claim
211 words
A composition of matter useful in sensing the concentration of an ionic component in a medium comprising: a first layer including a first matrix material which is solid and is permeable to the ionic component, and a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies; and a second layer which includes a second matrix material which is solid, is permeable to the ionic component, and is compatible with said first matrix material, and an opaque agent in an amount sufficient to render said second layer effectively opaque, said first layer and said second layer being partially intermingled to form an intermingled zone; wherein said second layer and said intermingled zone are formed by solubilizing said second matrix material in a liquid medium, contacting said first layer with said liquid medium such that a portion of said first matrix material in said first layer is also solubilized in said liquid medium, and solidifying the solubilized first matrix material and the solubilized second matrix material such that said solidified first matrix material and a portion of said solidified second matrix material form said intermingled zone and the remainder of said solidified second matrix material forms said second layer.
Claim 2
Dependent Claim
211 words
A composition of matter useful in sensing the concentration of an ionic component in a medium comprising: a first layer including a first matrix material which is solid and is permeable to the ionic component, and a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies; and a second layer which includes a second matrix material which is solid, is permeable to the ionic component, and is compatible with said first matrix material, and an opaque agent in an amount sufficient to render said second layer effectively opaque, said first layer and said second layer being partially intermingled to form an intermingled zone; wherein said second layer and said intermingled zone are formed by solubilizing said second matrix material in a liquid medium, contacting said first layer with said liquid medium such that a portion of said first matrix material in said first layer is also solubilized in said liquid medium, and solidifying the solubilized first matrix material and the solubilized second matrix material such that said solidified first matrix material and a portion of said solidified second matrix material form said intermingled zone and the remainder of said solidified second matrix material forms said second layer.
Claim 3
Dependent Claim
18 words
The composition of claim 1 wherein both said first matrix material and said second matrix material are polymeric.
Claim 4
Dependent Claim
21 words
The composition of claim 1 wherein said first matrix material and said second matrix material have substantially the same chemical composition.
Claim 5
Dependent Claim
18 words
The composition of claim 1 wherein both said first matrix material and said second matrix material are cellulose.
Claim 6
Dependent Claim
27 words
The composition of claim 1 wherein both said first matrix material and said second matrix material are cellulose and said liquid medium is an aqueous basic medium.
Claim 7
Dependent Claim
26 words
The composition of claim 5 wherein said liquid medium includes a basic component selected from the group consisting of metal hydroxides, organic amines and mixtures thereof.
Claim 8
Dependent Claim
16 words
The composition of claim 1 wherein the ionic component is H + or OH - .
Claim 9
Dependent Claim
13 words
The composition of claim 1 wherein said sensing component is an optical indicator.
Claim 10
Dependent Claim
13 words
The composition of claim 1 wherein said sensing component is a fluorescence indicator.
Claim 11
Dependent Claim
27 words
The composition of claim 1 wherein said sensing component is selected from the group consisting of hydroxypyrene trisulfonic acid, derivatives of hydroxypyrene trisulfonic acid, and mixtures thereof.
Claim 12
Dependent Claim
22 words
The composition of claim 1 wherein said second layer acts to substantially optically isolate at least a portion of said first layer.
Claim 13
Dependent Claim
33 words
The composition of claim 1 wherein the ratio of the thickness of the first layer to the thickness of the intermingled zone is within the range of from about 1:0.005 to about 1:0.25.
Claim 14
Independent Claim
223 words
An apparatus useful in sensing the concentration of an ionic component in a medium comprising: sensor means comprising a first layer which includes a first matrix material which is solid and is permeable to the ionic component and a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, and a second layer which includes a second matrix material which is solid, is permeable to the ionic component, and is compatible with said first matrix material and an opaque agent in an amount sufficient to render said second layer effectively opaque, said first and second layers being partially intermingled to form an intermingled zone; wherein said second layer and said intermingled zone are formed by solubilizing said second matrix material in a liquid medium, contacting said first layer with said liquid medium such that a portion of said first matrix material in said first layer is also solubilized in said liquid medium, and solidifying the solubilized first matrix material and the solubilized second matrix material such that said solidified first matrix material and a portion of said solidified second matrix material form said intermingled zone and the remainder of said solidified second matrix material forms said second layer; and signal means capable of transmitting said signal from said sensing component.
Claim 15
Independent Claim
223 words
An apparatus useful in sensing the concentration of an ionic component in a medium comprising: sensor means comprising a first layer which includes a first matrix material which is solid and is permeable to the ionic component and a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, and a second layer which includes a second matrix material which is solid, is permeable to the ionic component, and is compatible with said first matrix material and an opaque agent in an amount sufficient to render said second layer effectively opaque, said first and second layers being partially intermingled to form an intermingled zone; wherein said second layer and said intermingled zone are formed by solubilizing said second matrix material in a liquid medium, contacting said first layer with said liquid medium such that a portion of said first matrix material in said first layer is also solubilized in said liquid medium, and solidifying the solubilized first matrix material and the solubilized second matrix material such that said solidified first matrix material and a portion of said solidified second matrix material form said intermingled zone and the remainder of said solidified second matrix material forms said second layer; and signal means capable of transmitting said signal from said sensing component.
Claim 16
Dependent Claim
21 words
The apparatus of claim 13 wherein said sensing component is an optical indicator and said signal means comprises an optical fiber.
Claim 17
Dependent Claim
27 words
The apparatus of claim 14 wherein both said first matrix material and said second matrix material are cellulose and said liquid medium is an aqueous basic medium.
Claim 18
Dependent Claim
26 words
The apparatus of claim 15 wherein said liquid medium includes a basic component selected from the group consisting of metal hydroxides, organic amines and mixtures thereof.
Claim 19
Dependent Claim
16 words
The apparatus of claim 14 wherein said optical indicator is spaced apart from said optical fiber.
Claim 20
Dependent Claim
53 words
The apparatus of claim 13 further comprising holder means includes a cavity having an open end and being sized and adapted to receive at least a portion of said first layer, said sensor means being structured and oriented so that said first layer is located away from said open end of said cavity.
Claim 21
Dependent Claim
27 words
The apparatus of claim 18 wherein said holder means is substantially transparent, and said second layer, together with said holder means, substantially completely surrounds said first layer.
Claim 22
Dependent Claim
33 words
The apparatus of claim 13 wherein the ratio of the thickness of the first layer to the thickness of the intermingled zone is within the range of from about 1:0.005 to about 1:0.25.
Claim 23
Independent Claim
251 words
A method for sensing the concentration of an ionic component in a medium comprising: contacting said medium with a composition comprising a first layer including a first matrix material which is solid and is permeable to the ionic component and a sensing component in an amount effective to provide a signal which varies as the concentration of said ionic component in said medium varies, and a second layer which includes a second matrix material which is solid, is permeable to the ionic component, and is compatible with said first matrix material and an opaque agent in an amount sufficient to render said second layer effectively opaque, said first layer and said second layer being partially intermingled to form an intermingled zone; wherein said second layer and said intermingled zone are formed by solubilizing said second matrix material in a liquid medium contacting said first layer with said liquid medium such that a portion of said first matrix material in said first layer is also solubilized in said liquid medium, and solidifying the solubilized first matrix material and the solubilized second matrix material such that said solidified first matrix material and a portion of said solidified second matrix material form said intermingled zone and the remainder of said solidified second matrix material forms said second layer; causing said sensing component to emit a signal which varies as the concentration of said ionic component in said medium varies; and analyzing said signal to determine the concentration of said ionic component in said medium.
Claim 24
Independent Claim
251 words
A method for sensing the concentration of an ionic component in a medium comprising: contacting said medium with a composition comprising a first layer including a first matrix material which is solid and is permeable to the ionic component and a sensing component in an amount effective to provide a signal which varies as the concentration of said ionic component in said medium varies, and a second layer which includes a second matrix material which is solid, is permeable to the ionic component, and is compatible with said first matrix material and an opaque agent in an amount sufficient to render said second layer effectively opaque, said first layer and said second layer being partially intermingled to form an intermingled zone; wherein said second layer and said intermingled zone are formed by solubilizing said second matrix material in a liquid medium contacting said first layer with said liquid medium such that a portion of said first matrix material in said first layer is also solubilized in said liquid medium, and solidifying the solubilized first matrix material and the solubilized second matrix material such that said solidified first matrix material and a portion of said solidified second matrix material form said intermingled zone and the remainder of said solidified second matrix material forms said second layer; causing said sensing component to emit a signal which varies as the concentration of said ionic component in said medium varies; and analyzing said signal to determine the concentration of said ionic component in said medium.
Claim 25
Dependent Claim
10 words
The method of claim 21 wherein said medium is blood.
Claim 26
Dependent Claim
16 words
The method of claim 21 wherein said ionic component is H + or OH - .
Claim 27
Dependent Claim
18 words
The method of claim 21 wherein said both first matrix material and said second matrix material are polymeric.
Claim 28
Dependent Claim
18 words
The method of claim 21 wherein both said first matrix material and said second matrix material are cellulose.
Claim 29
Dependent Claim
27 words
The method of claim 21 wherein both said first matrix material and said second matrix material are cellulose and said liquid medium is an aqueous basic medium.
Claim 30
Dependent Claim
35 words
The method of claim 21 wherein said sensing component is selected from the group consisting of hydroxypyrene trisulfonic acid, derivatives of hydroxypyrene trisulfonic acid, and mixtures thereof, and wherein said opaque agent is carbon black.
Claim 31
Dependent Claim
33 words
The method of claim 21 wherein the ratio of the thickness of the first layer to the thickness of the intermingled zone is within the range of from about 1:0.005 to about 1:0.25.
Claim 32
Independent Claim
167 words
A method for making a sensor useful in sensing the concentration of an ionic component in a medium comprising: applying to a surface of a first layer of liquid composition, said first layer comprising a first matrix material which is solid prior to said applying and a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, said liquid composition comprising a liquid medium, an opaque agent, and a second matrix material which is compatible with said first matrix material and which is solubilized in said liquid medium, a portion of said first matrix material from said first layer becoming solubilized in said liquid medium upon said applying; and solidifying the solubilized second matrix material and the solubilized first matrix material such that said solidified first matrix material and a portion of said solidified second matrix material form an intermingled zone and the remainder of said solidified second matrix material forms a second layer.
Claim 33
Independent Claim
167 words
A method for making a sensor useful in sensing the concentration of an ionic component in a medium comprising: applying to a surface of a first layer of liquid composition, said first layer comprising a first matrix material which is solid prior to said applying and a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, said liquid composition comprising a liquid medium, an opaque agent, and a second matrix material which is compatible with said first matrix material and which is solubilized in said liquid medium, a portion of said first matrix material from said first layer becoming solubilized in said liquid medium upon said applying; and solidifying the solubilized second matrix material and the solubilized first matrix material such that said solidified first matrix material and a portion of said solidified second matrix material form an intermingled zone and the remainder of said solidified second matrix material forms a second layer.
Claim 34
Dependent Claim
27 words
The method of claim 29 wherein both said first matrix material and said second matrix material are cellulose and said liquid medium is an aqueous basic medium.
Claim 35
Dependent Claim
13 words
The method of claim 30 wherein said aqueous basic medium includes an amine.
Claim 36
Dependent Claim
17 words
The method of claim 30 wherein said aqueous basic medium comprises water, cupric hydroxide and ethylene diamine.
Claim 37
Dependent Claim
22 words
The method of claim 29 which further comprises positioning said first layer in proximity to the optical surface of an optical fiber.
Claim 38
Dependent Claim
38 words
The method of claim 29 wherein both said first matrix material and said second matrix material are polymeric and wherein said first layer is positioned in a cavity of a sensor holder, said cavity having an open end.
Claim 39
Dependent Claim
18 words
The method of claim 29 wherein both said first matrix material and said second matrix material are cellulose.
Claim 40
Dependent Claim
27 words
The method of claim 35 wherein said solidifying step includes contacting said solubilized second matrix material and said solubilized first matrix material with an aqueous acidic medium.
Claim 41
Dependent Claim
21 words
The method of claim 29 wherein said first matrix material and said second matrix material have substantially the same chemical composition.
Claim 42
Dependent Claim
33 words
The method of claim 29 wherein the ratio of the thickness of the first layer to the thickness of the intermingled zone is within the range of from about 1:0.005 to about 1:0.25.
Claim 43
Independent Claim
165 words
A method of making a sensor useful in sensing the concentration of an ionic component in a medium comprising: applying to a surface of a first composition a second composition, said first composition comprising a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies and a first matrix material which is solid prior to said applying, said second composition comprising a liquid medium, an opaque agent, and a second matrix material which is compatible with said first matrix material and is solubilized in said liquid medium, a portion of said first matrix material from said first composition becoming solubilized in said liquid medium upon said applying, both said first matrix material and said second matrix material being cellulose, said liquid medium including a basic component selected from the group consisting of metal hydroxides, organic amines, and mixtures thereof; and solidifying the solubilized second matrix material and the solubilized first matrix material.
Claim 44
Independent Claim
165 words
A method of making a sensor useful in sensing the concentration of an ionic component in a medium comprising: applying to a surface of a first composition a second composition, said first composition comprising a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies and a first matrix material which is solid prior to said applying, said second composition comprising a liquid medium, an opaque agent, and a second matrix material which is compatible with said first matrix material and is solubilized in said liquid medium, a portion of said first matrix material from said first composition becoming solubilized in said liquid medium upon said applying, both said first matrix material and said second matrix material being cellulose, said liquid medium including a basic component selected from the group consisting of metal hydroxides, organic amines, and mixtures thereof; and solidifying the solubilized second matrix material and the solubilized first matrix material.
Claim 45
Dependent Claim
145 words
A composition of matter useful in sensing the concentration of an ionic component in a medium comprising: a first layer including a first matrix material which is solid and is permeable to the ionic component, and a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies; and a second layer which includes a second matrix material which is solid, is permeable to the ionic component, and is compatible with said first matrix material, and an opaque agent in an amount sufficient to render said second layer effectively opaque, said first layer and said second layer being partially intermingled to form an intermingled zone; wherein the ratio of the thickness of the first layer to the thickness of the intermingled zone is within the range of from about 1:0.005 to about 1:0.25.
Claim 46
Dependent Claim
145 words
A composition of matter useful in sensing the concentration of an ionic component in a medium comprising: a first layer including a first matrix material which is solid and is permeable to the ionic component, and a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies; and a second layer which includes a second matrix material which is solid, is permeable to the ionic component, and is compatible with said first matrix material, and an opaque agent in an amount sufficient to render said second layer effectively opaque, said first layer and said second layer being partially intermingled to form an intermingled zone; wherein the ratio of the thickness of the first layer to the thickness of the intermingled zone is within the range of from about 1:0.005 to about 1:0.25.
Claim 47
Dependent Claim
16 words
The composition of claim 40 wherein the ionic component is H + or OH - .
References Cited (Backward Citations)
US3449080A
Cited
US3865548A
Cited
US3904373A
Cited
USRE31879E
Cited
US4194877A
Cited
US4321057A
Cited
US4600310A
Cited
US4557900A
Cited
US4568518A
Cited
US4543335A
Cited
US4577309A
Cited
US4775514A
Cited
US4548907A
Cited
US4637978A
Cited
US4640820A
Cited
US4919891A
Cited
US4801551A
Cited
US4824789A
Cited
US4824789B1
Cited
US4833091A
Cited
US4851195A
Cited
US4954318A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-13 | 1995-07-15 | 1996-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-13 | 1999-07-15 | 2000-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-13 | 2003-07-15 | 2004-01-14 | $7700.00 | Window Closed / Lapsed |