US5085864A
Expired / Lapsed
US
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Injectable formulation for lipophilic drugs
Assignee: Abbott Laboratories
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Filing: 1991-05-20
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Granted: 1992-02-04
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Expires: 2011-05-20
Abstract
Abstract An injectable drug composition including a therapeutically effective amount of a lipophilic drug and a bile salt.
Inventors
- 👤 John B. Cannon
- 👤 Chung-Chiang Hsu
- 👤 Karen J. Papp
- 👤 N. Adeyinka Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/10; A61K9/107; A61K9/1075
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
30 words
An injectable composition containing micelles which comprise a therapeutically effective amount of a lipophilic drug selected from the group consisting of erythromycin and clarithromycin and at least one bile salt.
Claim 2
Dependent Claim
30 words
An injectable composition containing micelles which comprise a therapeutically effective amount of a lipophilic drug selected from the group consisting of erythromycin and clarithromycin and at least one bile salt.
Claim 3
Dependent Claim
11 words
The composition of claim 1 wherein the bile salt is glycodeoxycholate.
Claim 4
Dependent Claim
14 words
The composition of claim 1 further comprising an agent which prevents or retards hemolysis.
Claim 5
Dependent Claim
18 words
The composition of claim 3 wherein the agent is selected from the group consisting of albumin and phospholipid.
Claim 6
Dependent Claim
25 words
The composition of claim 2 wherein the glycodeoxycholate is present in a molar ratio to the lipophilic drug of between about 2.5:1 and about 25:1.
Claim 7
Dependent Claim
26 words
The composition of claim 3 wherein the agent is phospholipid present in a molar ratio to the bile salt of between about 1:3 and about 1:1.
Claim 8
Dependent Claim
16 words
An injectable composition containing micelles which comprise a therapeutically effective amount of clarithromycin, glycodeoxycholate and phospholipid.
Claim 9
Dependent Claim
16 words
An injectable composition containing micelles which comprise a therapeutically effective amount of clarithromycin, glycodeoxycholate and phospholipid.
Claim 10
Dependent Claim
20 words
The composition of claim 7 wherein the clarithromycin, glycodeoxycholate and phospholipid are present in a molar ratio of about 1:3:2.
Claim 11
Independent Claim
48 words
A method for retreating or preventing a bacterial infection comprising administering intravenously, to a patient in need of treatment, a composition containing micelles which comprise a therapeutically effective amount of a lipophilic drug selected from the group consisting of erythromycin and clarithromycin and at least one bile salt.
Claim 12
Independent Claim
48 words
A method for retreating or preventing a bacterial infection comprising administering intravenously, to a patient in need of treatment, a composition containing micelles which comprise a therapeutically effective amount of a lipophilic drug selected from the group consisting of erythromycin and clarithromycin and at least one bile salt.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-02-03 | 1995-08-05 | 1996-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-02-03 | 1999-08-05 | 2000-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-02-03 | 2003-08-05 | 2004-02-04 | $7700.00 | Window Closed / Lapsed |