US5106758A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analytical test device and the use thereof
Assignee: Bayer Corp
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Filing: 1988-12-12
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Granted: 1992-04-21
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Expires: 2008-12-12
Abstract
Abstract The analytical device includes a base adapted to support a porous member having dispersed throughout at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of the analyte in the test sample. A cover integral with the base is provided with a reaction well adapted for storing a dried reaction component and for receiving the liquid test sample deposited on the analytical device whereby the liquid test sample and the reaction component form a liquid reaction mixture therein. A passage is included in the reaction well for selectively transferring the reaction mixture therethrough. This passage is normally spaced from the porous member and effectively closed to transfer therethrough of the reaction mixture, and is selectively movable toward the porous member to effectively open to passage therethrough of the reaction mixture whereby the analyte responsive substance will undergo a detectable response to the analyte present in the liquid reaction mixture. The base is provided with a suitable viewing port to permit monitoring of the detectable response generated as a result of the at least one analyte responsive substance interacting with the analyte in the test sample. Such a detectable response may be detected by appropriate photometric or colorimetric apparatus.
Inventors
- 👤 Stanford L. Adler
- 👤 John Campisi
- 👤 Koon-Wah Leong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:25
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525; G01N33/528; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
286 words
An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising: a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage means in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to said porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said cover means includes a central portion, said reaction well positioned within said central portion and deflective means in the form of a deformable circumferential corrugation around said central portion integral with said center portion and said cover means to impart flexibility of said central portion in said cover means so that said central portion may be displaced towards said porous member.
Claim 2
Dependent Claim
286 words
An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising: a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage means in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to said porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said cover means includes a central portion, said reaction well positioned within said central portion and deflective means in the form of a deformable circumferential corrugation around said central portion integral with said center portion and said cover means to impart flexibility of said central portion in said cover means so that said central portion may be displaced towards said porous member.
Claim 3
Dependent Claim
44 words
The apparatus of claim 1 wherein said passage means is normally open and is sized such that surface tension of said liquid reaction mixture with said reaction well prevents said liquid reaction mixture held in said reaction well from transfer through said passage means.
Claim 4
Dependent Claim
36 words
The apparatus of claim 2 wherein said liquid reaction mixture held by said reaction well is drawn through said passage means by capillary attraction when said passage means is moved into engagement with said porous member.
Claim 5
Dependent Claim
17 words
The apparatus of claim 1 wherein said reaction well is a conical depression in said cover means.
Claim 6
Dependent Claim
27 words
The apparatus of claim 1 wherein said reaction component is a dry substance within said reaction well and is reconstituted upon contact with said liquid test sample.
Claim 7
Dependent Claim
265 words
An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising: a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage means in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to aid porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said reaction well is a cylindrical depression in said cover means and said passage means includes a projection centrally positioned within said cylindrical depression and at least two support arms extending from said projection to said reaction well defining openings therebetween.
Claim 8
Dependent Claim
265 words
An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising: a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage means in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to aid porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said reaction well is a cylindrical depression in said cover means and said passage means includes a projection centrally positioned within said cylindrical depression and at least two support arms extending from said projection to said reaction well defining openings therebetween.
Claim 9
Dependent Claim
27 words
The apparatus of claim 6 wherein said reaction component is a dry substance within said reaction well and is reconstituted upon contact with said liquid test sample.
Claim 10
Dependent Claim
271 words
An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising: a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage mans in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to said porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said reaction well is a cylindrical depression in said cover means and said passage means includes a projection centrally positioned within said cylindrical depression and a transverse wall extending from said projection to said reaction well and having openings therein normally substantially closed to fluid passage therethrough.
Claim 11
Dependent Claim
271 words
An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising: a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage mans in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to said porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said reaction well is a cylindrical depression in said cover means and said passage means includes a projection centrally positioned within said cylindrical depression and a transverse wall extending from said projection to said reaction well and having openings therein normally substantially closed to fluid passage therethrough.
Claim 12
Dependent Claim
27 words
The apparatus of claim 8 wherein said reaction component is a dry substance within said reaction well and is reconstituted upon contact with said liquid test sample.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-04-21 | 1995-10-21 | 1996-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-04-21 | 1999-10-21 | 2000-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-04-21 | 2003-10-21 | 2004-04-21 | $7700.00 | Window Closed / Lapsed |