US5124081A
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Amphiphilic lipid compounds, process for their preparation and their applications especially in cosmetics and dermopharmacy
Assignee: L'Oréal SA
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Filing: 1986-06-24
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Granted: 1992-06-23
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Expires: 2006-06-24
Abstract
Abstract Amphiphilic lipid compound having the formula: <IMAGE> (I) in which: R1 denotes a C7-C21 alkyl or alkenyl radical, R2 denotes a saturated or unsaturated C7-C31 hydrocarbon radical, COA denotes a group chosen from the following groups: a) COOM, M being H, Na, K, NH4 or a substituted ammonium ion derived from an amine, b) <IMAGE> B being a radical derived from mono- or polyhydroxylated primary or secondary amines and R denoting a hydrogen atom or a methyl, ethyl or hydroxyethyl radical, c) <IMAGE> Q denoting a substituted aminoalkyl or ammonioalkyl radical and R having the meaning indicated for b), and d) COOZ, Z representing the residue of a C3-C7 polyol, and a process for its preparation. Cosmetic or dermopharmaceutical composition comprising the said compound and especially an aqueous dispersion of liposomes.
Inventors
- 👤 Guy Vanlerberghe
- 👤 Alexandre Zysman
- 👤 Henri Sebag
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 08:52
CPC Classifications
A; A61; A61Q; A61Q5/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/68; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/1272; A61Q19/00; C; C07; C07D; C07D207/00; C07D207/46; C07H; C07H15/00; C07H15/02; C07H15/04; A61Q19/007; A61Q19/08; A61Q5/12
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
83 words
An amphiphilic lipid compound having the formula ##STR31## wherein R 1 represents a C 7 -C 21 alkyl or alkenyl radical. R 2 represents a saturated or unsaturated C 7 -C 31 hydrocarbon radical or a saturated or unsaturated C 7 -C 31 hydrocarbon radical or a saturated or unsaturated C 7 -C 31 hydrocarbon radical bearing one or more hydroxyl groups, and COA represents COOM wherein M is H, Na, K, NH 4 or a substituted ammonium ion derived from an amine.
Claim 2
Dependent Claim
83 words
An amphiphilic lipid compound having the formula ##STR31## wherein R 1 represents a C 7 -C 21 alkyl or alkenyl radical. R 2 represents a saturated or unsaturated C 7 -C 31 hydrocarbon radical or a saturated or unsaturated C 7 -C 31 hydrocarbon radical or a saturated or unsaturated C 7 -C 31 hydrocarbon radical bearing one or more hydroxyl groups, and COA represents COOM wherein M is H, Na, K, NH 4 or a substituted ammonium ion derived from an amine.
Claim 3
Dependent Claim
88 words
An amphiphilic lipid compound having the formula ##STR32## wherein R 1 represents a C 7 -C 21 alkyl or alkenyl radical, R 2 represents a saturated or unsaturated C 7 -C 31 hydrocarbon radical or a saturated or unsaturated C 7 -C 31 hydrocarbon radical bearing one or more hydroxyl groups, and COA represents (a) COOM wherein M is H, Na, K, NH 4 or a substituted ammonium ion derived from an amine or (b) COOZ wherein Z represents the residue of a C 3 -C 7 polyol.
Claim 4
Dependent Claim
88 words
An amphiphilic lipid compound having the formula ##STR32## wherein R 1 represents a C 7 -C 21 alkyl or alkenyl radical, R 2 represents a saturated or unsaturated C 7 -C 31 hydrocarbon radical or a saturated or unsaturated C 7 -C 31 hydrocarbon radical bearing one or more hydroxyl groups, and COA represents (a) COOM wherein M is H, Na, K, NH 4 or a substituted ammonium ion derived from an amine or (b) COOZ wherein Z represents the residue of a C 3 -C 7 polyol.
Claim 5
Dependent Claim
29 words
An amphiphilic lipid compound having the formula ##STR33## wherein R 2 represents a hydrocarbon chain of the formula: --(CH 2 ) 7 --CH═CH--(CH 2 ) 7 --CH 3 .
Claim 6
Dependent Claim
29 words
An amphiphilic lipid compound having the formula ##STR33## wherein R 2 represents a hydrocarbon chain of the formula: --(CH 2 ) 7 --CH═CH--(CH 2 ) 7 --CH 3 .
Claim 7
Dependent Claim
142 words
An amphiphilic lipid compound having the formula: ##STR34## R 1 represents C 7 -C 21 alkyl or C 7 -C 21 alkenyl, R 2 represents a saturated or unsaturated C 7 -C 31 hydrocarbon radical or a saturated or unsaturated C 7 -C 31 hydrocarbon radical substituted with at least one hydroxyl group, COA represents a radical selected from the group consisting of (a) COOM wherein M represents H, Na, K, NH 4 or a substituted ammonium ion derived from an amine, (b) ##STR35## wherein B is a radical derived from a mono- or polyhydroxylated primary or secondary amine, and R represents hydrogen, methyl, ethyl or hydroxyethyl, (c) ##STR36## wherein Q represents a substituted aminoalkyl or ammonioalkyl radical, and R has the meaning indicated in (b) above, and (d) COOZ wherein Z represents the residue of a C 2 -C 7 polyol.
Claim 8
Dependent Claim
142 words
An amphiphilic lipid compound having the formula: ##STR34## R 1 represents C 7 -C 21 alkyl or C 7 -C 21 alkenyl, R 2 represents a saturated or unsaturated C 7 -C 31 hydrocarbon radical or a saturated or unsaturated C 7 -C 31 hydrocarbon radical substituted with at least one hydroxyl group, COA represents a radical selected from the group consisting of (a) COOM wherein M represents H, Na, K, NH 4 or a substituted ammonium ion derived from an amine, (b) ##STR35## wherein B is a radical derived from a mono- or polyhydroxylated primary or secondary amine, and R represents hydrogen, methyl, ethyl or hydroxyethyl, (c) ##STR36## wherein Q represents a substituted aminoalkyl or ammonioalkyl radical, and R has the meaning indicated in (b) above, and (d) COOZ wherein Z represents the residue of a C 2 -C 7 polyol.
Claim 9
Dependent Claim
46 words
The compound of claim 4 wherein COA represents COOM wherein M represents H, Na, K, NH 4 or a substituted ammonium ion derived from a hydroxyalkylamine selected from the group consisting of mono-, di- or triethanolamine, mono-, di- or triisopropanolamine, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propane diol and tris(hydroxymethyl) aminomethane.
Claim 10
Dependent Claim
33 words
The compound of claim 4 wherein COA represents COOZ wherein Z represents the residue of a C 3 -C 7 polyol selected from the group consisting of glycerol, glucose, methyl glucose and sorbitol.
Claim 11
Dependent Claim
63 words
A composition for the treatment of hair or skin so as to prevent or correct the drying of the hair or skin, said composition comprising in a medium suitable for application to said hair or skin, the amphiphilic lipid compound of claim 4 present in an amount ranging from 0.2 to 50 percent by weight based on the total weight of said composition.
Claim 12
Dependent Claim
31 words
The composition of claim 7 wherein said amphiphilic lipid compound is present in an amount ranging from 0.5 to 25 percent by weight based on the total weight of said composition.
Claim 13
Dependent Claim
86 words
The composition of claim 7 in the form of an emulsion comprising an oily phase, an aqueous phase, and an emulsifying agent, said oily phase constituting 5 to 60 weight percent of said emulsion and comprising a mixture of said amphiphilic compound and at least one oil, said aqueous phase constituting 30-85 weight percent of said emulsion, and said emulsifying agent comprising said amphiphilic lipid compound present in an amount ranging from 1 to 20 percent by weight based on the total weight of said emulsion.
Claim 14
Dependent Claim
30 words
The composition of claim 9 wherein said emulsifying agent is present in an amount ranging from 2 to 12 percent by weight based on the total weight of said emulsion.
Claim 15
Dependent Claim
26 words
The composition of claim 7 in the form of an aqueous solution, an aqueous-alcoholic solution, an oily solution, an oleoalcoholic solution, a gel or a dispersion.
Claim 16
Dependent Claim
12 words
The composition of claim 7 in the form of a solid stick.
Claim 17
Dependent Claim
50 words
The composition of claim 7 in the form of a dispersion of spherules or liposomes surrounded by a continuous aqueous phase, said spherules or liposomes comprising organized molecular layers of said amphiphilic lipid compound and encapsulating an aqueous phase selected from water or an aqueous solution of an active product.
Claim 18
Dependent Claim
37 words
The composition of claim 13 wherein said aqueous phase encapsulated in said spherules or liposomes is an aqueous solution of an active substance which is isoosmotic relative to said continuous aqueous phase surrounding said spherules or liposomes.
Claim 19
Dependent Claim
20 words
The composition of claim 13 wherein the diameter of said spherules or liposomes ranges from 0.1 μm to 5 μm.
Claim 20
Dependent Claim
20 words
The composition of claim 13 wherein the aqueous phase encapsulated in said spherules or liposomes contains a cosmetically active adjuvant.
Claim 21
Dependent Claim
20 words
The composition of claim 13 wherein the aqueous phase encapsulated in said spherules or liposomes contains a dermopharmaceutically active substance.
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