US5130116A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiotherapeutic immunoconjugates labeled with iodine-125
Assignee: Janssen Biotech Inc
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Filing: 1990-05-29
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Granted: 1992-07-14
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Expires: 2010-05-29
Abstract
Abstract A radiotherapeutic immunoconjugate comprising a tumor specific monoclonal antibody, or fragment thereof, and an Auger electron emitting radionuclide, wherein the tumor specific monoclonal antibody or fragment is capable of tumor nucleus localization of the radionuclide and method of using it is disclosed. The radiotherapeutic immunoconjugate is administered in a therapeutically effective amount to patients having or suspected of having a malignancy reactive with the antibody or fragment.
Inventors
- 👤 David V. Woo
- 👤 Zenon Steplewski
- 👤 Jeffrey A. Mattis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:54
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1045; A61P; A61P35/00; A61K2121/00; A61K2123/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
50 words
A method for delivering a cytotoxic radionuclide to the nuclei of tumor cells in vivo comprising contacting the tumor cells with an immunoconjugate comprising monoclonal antibody 17-1A, or a fragment thereof, labeled with 125 I, wherein the monoclonal antibody is capable of localizing the radionuclide at the tumor cell nucleus.
Claim 2
Independent Claim
50 words
A method for delivering a cytotoxic radionuclide to the nuclei of tumor cells in vivo comprising contacting the tumor cells with an immunoconjugate comprising monoclonal antibody 17-1A, or a fragment thereof, labeled with 125 I, wherein the monoclonal antibody is capable of localizing the radionuclide at the tumor cell nucleus.
Claim 3
Independent Claim
50 words
A method for delivering a cytotoxic radionuclide to the nuclei of tumor cells in vivo comprising contacting the tumor cells with an immunoconjugate comprising monoclonal antibody c17-1A, or a fragment thereof, labeled with 125 I, wherein the monoclonal antibody is capable of localizing the radionuclide at the tumor cell nucleus.
Claim 4
Independent Claim
50 words
A method for delivering a cytotoxic radionuclide to the nuclei of tumor cells in vivo comprising contacting the tumor cells with an immunoconjugate comprising monoclonal antibody c17-1A, or a fragment thereof, labeled with 125 I, wherein the monoclonal antibody is capable of localizing the radionuclide at the tumor cell nucleus.
Claim 5
Independent Claim
60 words
A method for treating a patient having a 17-1A positive malignancy comprising administering to the patient a therapeutically effective amount of a radiotherapeutic immunoconjugate consisting essentially of a monoclonal antibody, or fragment thereof, specific for CA 17-1A and 125 I, wherein the antibody or fragment is capable of localizing the 125 I radionuclide in the nuclei of the malignant cells.
Claim 6
Independent Claim
60 words
A method for treating a patient having a 17-1A positive malignancy comprising administering to the patient a therapeutically effective amount of a radiotherapeutic immunoconjugate consisting essentially of a monoclonal antibody, or fragment thereof, specific for CA 17-1A and 125 I, wherein the antibody or fragment is capable of localizing the 125 I radionuclide in the nuclei of the malignant cells.
Claim 7
Dependent Claim
35 words
A method according to claim 3, wherein the radiotherapeutic immunoconjugate is administered in an amount of from about 20 to 200 milliCuries of radioactivity representing mass quantities of antibody of about 2 to 20 mg.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-14 | 1996-01-13 | 1996-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-14 | 2000-01-13 | 2000-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-14 | 2004-01-13 | 2004-07-14 | $7700.00 | Window Closed / Lapsed |