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US5162042A Expired / Lapsed US ⏱️ 0.0 years remaining

Electrotransport transdermal system

Assignee: Alza Corp
•
Filing: 1991-12-27
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Granted: 1992-11-10
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Expires: 2011-12-27
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Abstract

Abstract A transdermal therapeutic system which utilizes electrical current to facilitate drug delivery.

Inventors

  • 👤 J. Richard Gyory
  • 👤 Ronald P. Haak
  • 👤 Felix Theeuwes

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-04 03:58
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0432; A61N1/044; A61N1/0436; A61N1/0444; A61N1/0448

Claims Analysis

Total Claims: 19
Claim 1
Independent Claim 177 words
An electrotransport device for delivering a beneficial agent in the form of a water soluble salt through a body surface, comprising: A donor electrode electrically connected to a donor electrode pad containing the beneficial agent to be delivered, the donor electrode pad being positioned in beneficial agent ion transmitting relationship to said body surface; a counter electrode electrically connected to a counter electrode pad containing a water soluble electrolyte salt, the counter electrode pad being positioned in electrolyte salt ion transmitting relationship to said body surface at a location spaced apart from the donor electrode pad; a source of electrical power electrically connected to the donor and counter electrodes; wherein the donor electrode pad comprises a hydrophobic polymer matrix which is substantially free of any hydrophilic polymer, the hydrophobic polymer matrix containing the water soluble beneficial agent salt blended therein, the beneficial agent salt being present as about 25 to 90 weight % of the total blend of the reservoir and the agent, the blended beneficial agent salt creating a microporous structure in the hydrophobic polymer matrix.
Claim 2
Dependent Claim 177 words
An electrotransport device for delivering a beneficial agent in the form of a water soluble salt through a body surface, comprising: A donor electrode electrically connected to a donor electrode pad containing the beneficial agent to be delivered, the donor electrode pad being positioned in beneficial agent ion transmitting relationship to said body surface; a counter electrode electrically connected to a counter electrode pad containing a water soluble electrolyte salt, the counter electrode pad being positioned in electrolyte salt ion transmitting relationship to said body surface at a location spaced apart from the donor electrode pad; a source of electrical power electrically connected to the donor and counter electrodes; wherein the donor electrode pad comprises a hydrophobic polymer matrix which is substantially free of any hydrophilic polymer, the hydrophobic polymer matrix containing the water soluble beneficial agent salt blended therein, the beneficial agent salt being present as about 25 to 90 weight % of the total blend of the reservoir and the agent, the blended beneficial agent salt creating a microporous structure in the hydrophobic polymer matrix.
Claim 3
Dependent Claim 15 words
The device of claim 1, wherein the hydrophobic polymer comprises an ethylene vinyl acetate copolymer.
Claim 4
Dependent Claim 12 words
The device of claim 1, wherein the hydrophobic polymer comprises a polyalkene.
Claim 5
Dependent Claim 13 words
The device of claim 1, wherein the hydrophobic polymer comprises a polyisobutylene copolymer.
Claim 6
Dependent Claim 26 words
The device of claim 1, wherein the hydrophobic polymer comprises a mixture of a high molecular weight polyiosbutylene copolymer and a low molecular weight polyisobutylene copolymer.
Claim 7
Dependent Claim 24 words
The device of claim 1, wherein the donor electrode pad contains about 50 wt % of the beneficial agent on a dry weight basis.
Claim 8
Dependent Claim 14 words
The device of claim 1, wherein the donor electrode pad comprises a self-adhering matrix.
Claim 9
Dependent Claim 15 words
The device of claim 1, wherein the donor electrode pad also contains a resinous tackifier.
Claim 10
Dependent Claim 23 words
The device of claim 1, including a layer of an ion transmitting adhesive on a skin facing side of the donor electrode pad.
Claim 11
Dependent Claim 14 words
The device of claim 1, wherein the source of electrical power comprises a battery.
Claim 12
Dependent Claim 22 words
The device of claim 10, wherein the source of electrical power applies an electrical current density of about 100 μA/cm 2 .
Claim 13
Dependent Claim 13 words
The device of claim 1, wherein the donor electrode comprises a metal foil.
Claim 14
Dependent Claim 21 words
The device of claim 1, wherein the donor electrode comprises an electrochemically oxidizable or reducible powdered material in a binder matrix.
Claim 15
Dependent Claim 28 words
The device of claim 13, wherein the electrochemically oxidizable or reducible powdered material is selected from the group consisting of silver powder, zinc powder, and silver chloride powder.
Claim 16
Dependent Claim 13 words
The device of claim 1, wherein the beneficial agent salt comprises a drug.
Claim 17
Dependent Claim 10 words
The device of claim 15, wherein the drug comprises metoclopramide.
Claim 18
Dependent Claim 11 words
The device of claim 15, wherein the drug comprises a peptide.
Claim 19
Dependent Claim 11 words
The device of claim 15, wherein the drug comprises a protein.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1995-11-10 1996-05-11 1996-11-10 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1999-11-10 2000-05-11 2000-11-10 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2003-11-10 2004-05-11 2004-11-10 $7700.00 Window Closed / Lapsed

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