US5162525A
Expired / Lapsed
US
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Fluorogenic and chromogenic three-dimensional ionophores as selective reagents for detecting ions in biological fluids
Assignee: Honeywell International Inc
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Filing: 1987-07-31
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Granted: 1992-11-10
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Expires: 2007-07-31
Abstract
Abstract Novel fluorogenic and chromogenic three-dimensional ionophores are provided which selectively bond ions such as potassium, sodium, and lithium, even in neutral aqueous or alcohol media. The novel ionophores comprse an "ion-recognizing system" fused to a "signal-moiety" through one or more heteroatoms having a non-bonded electron pair. The signal-moieties are selected from the group consisting of fused ring heterocyclics, fused aromatics, and substituted aromatics having at least one nitro or azo moiety. The ion-recognizing system is a three-dimensional cryptand. The ionophores are ideal for the selective and direct termination of ions in biological or environmental samples and the like.
Inventors
- 👤 Davakaran Masilamani
- 👤 Mariann E. Lucas
- 👤 George S. Hammond
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:58
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/02; C07D498/08; C07D498/12; C07D498/18; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/86
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
99 words
An ionophore compound of an ion-recognizing system fused to a signal moiety through two heteroatoms having a non-bonded electron pair, having the formula: ##STR11## wherein: said signal moiety is selected from the group consisting of unsubstituted and substituted coumarins, and wherein said ion-recognizing system is a three dimensional cryptand, wherein X 1 , and X 2 of said cryptand are the same or different and are selected from the group consisting of S, p, N, O, and Se; and wherein the repeating units m and n are the same or different are each an integer of 0 to 12.
Claim 2
Dependent Claim
99 words
An ionophore compound of an ion-recognizing system fused to a signal moiety through two heteroatoms having a non-bonded electron pair, having the formula: ##STR11## wherein: said signal moiety is selected from the group consisting of unsubstituted and substituted coumarins, and wherein said ion-recognizing system is a three dimensional cryptand, wherein X 1 , and X 2 of said cryptand are the same or different and are selected from the group consisting of S, p, N, O, and Se; and wherein the repeating units m and n are the same or different are each an integer of 0 to 12.
Claim 3
Dependent Claim
18 words
The inophore compound of claim 1 wherein X 1 and X 2 are the same and are O.
Claim 4
Dependent Claim
18 words
The ionophore compound of claim 2 wherein n is from 0 to 3 and m is about 0-5.
Claim 5
Dependent Claim
17 words
The ionophore compound of claim 3 wherein n is 2 and the signal moiety is a coumarin.
Claim 6
Dependent Claim
60 words
The inophore compound of claim 1 wherein the inophore compound corresponds to a formula selected from the group consisting of: ##STR12## wherein R 1 , R 2 , R 3 and R 4 are the same or different and are N, hydroxyl, amine, alkyl, aromatic hydrocarbyl, fluoroalkyl, alkyloarbonyloxyl, carboxyl, alkoxyl, mercapto or alkylthio and 3-DC represents a 3 dimensional cryptand.
Claim 7
Dependent Claim
13 words
A compound having the following formula: ##STR13## wherein 3-DC is a 3-dimensional cryptand.
Claim 8
Dependent Claim
13 words
A compound having the following formula: ##STR13## wherein 3-DC is a 3-dimensional cryptand.
Claim 9
Dependent Claim
34 words
The compound of claim 5 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are selected from H and alkyl having 1 to 4 carbons.
Claim 10
Dependent Claim
31 words
The compound of claim 5 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are selected from H or methyl or ethyl.
Claim 11
Dependent Claim
24 words
A compound according to claim 5 having the formula: ##STR14## wherein said compound is a fluorogenic reagent selective for the detection of potassium ion.
Claim 12
Dependent Claim
23 words
A compound according to claim 5 having the formula: ##STR15## wherein said compound is a fluorogenic reagent for the detection of sodium ion.
Claim 13
Dependent Claim
23 words
A compound according to claim 5 having the formula: ##STR16## wherein said compound is a fluorogenic reagent for the detection of lithium ion.
References Cited (Backward Citations)
US4645744A
Cited
US4808539A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-10 | 1996-05-11 | 1996-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-10 | 2000-05-11 | 2000-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-10 | 2004-05-11 | 2004-11-10 | $7700.00 | Window Closed / Lapsed |