US5164598A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Capillary flow device
Assignee: Roche Diagnostics Operations Inc
•
Filing: 1991-02-05
•
Granted: 1992-11-17
•
Expires: 2011-02-05
Abstract
Abstract Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
Inventors
- 👤 Robert S. Hillman
- 👤 Michael E. Cobb
- 👤 Jimmy D. Allen
- 👤 Ian Gibbons
- 👤 Vladimir E. Ostoich
- 👤 Laura J. Winfrey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 23:47
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5027; B01F; B01F25/00; B01F25/40; B01F25/42; B01F25/43; B01F25/433; B01F25/431; B01F25/4316; B01F25/4338; B01F33/00; B01F33/30; B01F35/00; B01F35/71; B01F35/717; B01F35/7172; B29; B29C; B29C65/00; B29C65/02; B29C65/08; B29C66/00; B29C66/01; B29C66/05; B29C66/302; B29C66/3022; B29C66/30223; B29C66/50; B29C66/51; B29C66/54; B29C66/70; B29C66/73; B29C66/739; B29C66/7392; B29C66/73921; G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/82; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4905; G01N33/50; G01N33/86; B01F21/00; B01F2101/00; B01F2101/23; B01F23/00; B01F23/50; B01F23/56; B01L2300/00; B01L2300/06; B01L2300/0627; B01L2300/0654; B01L2300/0681; B01L2300/08; B01L2300/0809; B01L2300/0816; B01L2300/0825; B01L2300/0861; B01L2300/087; B01L2300/0887; B01L2400/00; B01L2400/04; B01L2400/0403; B01L2400/0406; B01L2400/06; B01L2400/0694; B01L3/502723; B29C45/00; B29C59/00; B29C59/16; B29C65/48; B29C65/4895; B29C66/71; B29C66/90; B29C66/95; B29C66/951; B29C66/9513; B29K; B29K2055/00; B29K2055/02; B29L; B29L2031/00; B29L2031/756; G01N15/00; G01N2015/0092; G01N15/10; G01N15/1012; G01N2015/1016; G01N21/01; G01N21/03; G01N2021/0346; G01N35/00; G01N2035/00465; G01N2035/00514; G01N21/17; G01N21/47; G01N21/49; G01N33/53; G01N33/543; G01N33/54366
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
105 words
A system for detecting the presence of an analyte in or a property of blood, comprising: a housing containing a capillary passageway capable of independently pumping blood into said passageway as the sole motive source in said passageway; a reagent contained within said passageway capable of causing said blood to clot to provide a detectable signal in relationship to said analyte or property; and a monitor comprising means for holding said housing, means for passing light through said capillary passageway, means for detecting scattering of light that passes through said passageway, and means for analyzing scattered light to determine when clotting occurs in said passageway.
Claim 2
Independent Claim
105 words
A system for detecting the presence of an analyte in or a property of blood, comprising: a housing containing a capillary passageway capable of independently pumping blood into said passageway as the sole motive source in said passageway; a reagent contained within said passageway capable of causing said blood to clot to provide a detectable signal in relationship to said analyte or property; and a monitor comprising means for holding said housing, means for passing light through said capillary passageway, means for detecting scattering of light that passes through said passageway, and means for analyzing scattered light to determine when clotting occurs in said passageway.
Claim 3
Independent Claim
94 words
A device for use in a system for detecting the presence of an analyte in a blood sample, comprising: a substantially hydrophobic housing having at least a portion of the walls treated to provide hydrophilicity, said housing comprising a capillary passageway having hydrophilic walls and being capable of pumping blood as the sole motive source in said device; and a reagent in said passageway, wherein said reagent causes blood to clot and is a member of a system capable of providing a detectable signal in relation to the presence of said analyte or property.
Claim 4
Independent Claim
94 words
A device for use in a system for detecting the presence of an analyte in a blood sample, comprising: a substantially hydrophobic housing having at least a portion of the walls treated to provide hydrophilicity, said housing comprising a capillary passageway having hydrophilic walls and being capable of pumping blood as the sole motive source in said device; and a reagent in said passageway, wherein said reagent causes blood to clot and is a member of a system capable of providing a detectable signal in relation to the presence of said analyte or property.
References Cited (Backward Citations)
DE2007405A1
Cited
SE376300B
Cited
US3799742A
Cited
US4135819A
Cited
US4088448A
Cited
US4964728A
Cited
US4233029A
Cited
US4492462A
Cited
US4876069A
Cited
DE3134611A1
Cited
US4948961A
Cited
US4963498A
Cited
US4756884A
Cited
US5004923A
Cited
US4849340A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-17 | 1996-05-18 | 1996-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-17 | 2000-05-18 | 2000-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-17 | 2004-05-18 | 2004-11-17 | $7700.00 | Window Closed / Lapsed |