Technetium chelates to be used for determining the renal function

Abstract

Abstract The invention relates to a method of preparing technetium chelate of the general formula ##STR1## wherein x is a sulphur atom or an imino group, Z is a hydrogen atom, a carboxy group, an alkoxycarbonyl group having 1-4 carbon atoms, an aminocarbonyl group, a sulpho group, an aminosulphonyl group or a carboxymethylaminocarbonyl group, Tc represents technetium-99m, R 1 is a hydrogen atom or an alkyl group having 1 or 2 carbon atoms, and R 2 , R 4 and R 5 are equal or different and represent hydrogen atoms or branched or non-branched alkyl groups having 1-4 carbon atoms, which alkyl groups are optionally substituted with an amino group, a hydroxy group, a mercapto group, a halogen atom, a carboxy group or an aminocarbonyl group, with the proviso that R 3 , R 4 and R 5 do not all three of them represent hydrogen atoms; as well as water-soluble salts of these compounds. The invention also relates to a tripeptide compound to be used for preparing said chelate and to a kit comprising a composition of said tripeptide compound.

Inventors

• 👤 Alfons M. Verbruggen

Bibliographic Details