Benzimidazole derivatives, their preparation and use

Abstract

Abstract A compound having the formula ##STR1## wherein R 1 is hydrogen, NH 2 or C 1-6 -alkyl which may be branched; X is O, S, NCN; Y is O, S; R 4 , R 5 , R 6 and R 7 independently of each other are hydrogen, halogen, CF 3 , NO 2 , NH 2 , OH, C 1-6 -alkoxy, C(═O)-phenyl or SO 2 NR I R II wherein R I and R II independently are hydrogen or C 1-6 -alkyl; R 11 is hydrogen, halogen, NO 2 or SO 2 NR'R" wherein R' and R" independently are hydrogen or C 1-6 -alkyl; R 13 is hydrogen, halogen, phenyl, CF 3 , NO 2 ; R 12 is hydrogen or together with R 13 forms a C 4-7 -carbocyclic ring which may be aromatic or partially saturated; R 14 is hydrogen or together with R 13 forms a C 4-7 -carbocyclic ring which may be aromatic or partially saturated; pharmaceutical compositions thereof, and a method of treating a disease in a mammal, including a human, responsive to opening of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound as first above indicated, are disclosed.

Inventors

• 👤 Soren-Peter Olesen
• 👤 Frank Watjen

Bibliographic Details