US5204085A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents
Assignee: Mallinckrodt Inc
•
Filing: 1991-11-18
•
Granted: 1993-04-20
•
Expires: 2011-11-18
Abstract
Abstract Paramagnetic chelates, as for example, Gadolinium diethylenetriaminepentaacetic acid (DTPA), manganese, ethylenediaminetetraacetic acid (EDTA), and others used as X-ray contrast agents are more toxic acutely when injected in high concentration or at rapid rates. The use of effective amounts of calcium in the form of, calcium chloride, calcium gluconate, or balanced salt solutions substantially reduces this toxicity without the need to add additional ligand.
Inventors
- 👤 Donald R. VanDeripe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 09:56
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
108 words
In a method for enhancing safety in the in vivo use of metal-ligand chelate complexes as X-ray contrast agents comprising administering to a mammal a diagnostically effective amount of a metal-ligand complex, the improvement comprising: adding calcium ions to a charge-balanced metal-ligand complex formed from the anion of a complexing acid and a central ion of an element with an atomic number of 57 to 83, said calcium ions being added in substantially less than stoichiometric amounted to the metal-ligand complex, said calcium ions being provided from a member of the group consisting of inorganic calcium salts, organic calcium salts and mixtures thereof without excess ligand being added.
Claim 2
Dependent Claim
108 words
In a method for enhancing safety in the in vivo use of metal-ligand chelate complexes as X-ray contrast agents comprising administering to a mammal a diagnostically effective amount of a metal-ligand complex, the improvement comprising: adding calcium ions to a charge-balanced metal-ligand complex formed from the anion of a complexing acid and a central ion of an element with an atomic number of 57 to 83, said calcium ions being added in substantially less than stoichiometric amounted to the metal-ligand complex, said calcium ions being provided from a member of the group consisting of inorganic calcium salts, organic calcium salts and mixtures thereof without excess ligand being added.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein the metal-ligand chelate complex is used in the form of a salt.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein the metal-ligand chelate complex is used in non-ionic form.
Claim 5
Dependent Claim
29 words
The method of claim 1 wherein the calcium ions are provided at levels of from about 1 to about 25% of the stoichiometric amount required by the metal-ligand complex.
Claim 6
Dependent Claim
23 words
The method of claim 4 wherein the calcium ions are provided at levels of about 3 to about 15% of the stoichiometric amount.
Claim 7
Dependent Claim
17 words
The method of claim 1 wherein the calcium ions are provided in the form of calcium chloride.
Claim 8
Dependent Claim
29 words
The method of claim 2 wherein the calcium ions are provided at levels of from about 1 to about 25% of the stoichiometric amount required by the metal-ligand complex.
Claim 9
Dependent Claim
29 words
The method of claim 3 wherein the calcium ions are provided at levels of from about 1 to about 25% of the stoichiometric amount required by the metal-ligand complex.
Claim 10
Dependent Claim
23 words
The method of claim 7 wherein the calcium ions are provided at levels of about 3 to about 15% of the stoichiometric amount.
Claim 11
Dependent Claim
23 words
The method of claim 8 wherein the calcium ions are provided at levels of about 3 to about 15% of the stoichiometric amount.
Claim 12
Dependent Claim
119 words
In a method for enhancing safety in the in vivo use of metal-ligand chelate complexes as X-ray contrast agents comprising administering to a mammal a diagnostically effective amount of a metal-ligand complex, the improvement comprising: adding calcium ions to a charge-balanced metal-ligand complex formed from the anion of a complexing acid and a central ion of an element with an atomic number of 57 to 83, said calcium ions being added in substantially less than stoichiometric amounts to the metal-ligand complex, said calcium ions being provided from a member of the group consisting of inorganic calcium salts, organic calcium salts and mixtures thereof and being added to any calcium present as the salt of an excess of said ligand.
Claim 13
Dependent Claim
119 words
In a method for enhancing safety in the in vivo use of metal-ligand chelate complexes as X-ray contrast agents comprising administering to a mammal a diagnostically effective amount of a metal-ligand complex, the improvement comprising: adding calcium ions to a charge-balanced metal-ligand complex formed from the anion of a complexing acid and a central ion of an element with an atomic number of 57 to 83, said calcium ions being added in substantially less than stoichiometric amounts to the metal-ligand complex, said calcium ions being provided from a member of the group consisting of inorganic calcium salts, organic calcium salts and mixtures thereof and being added to any calcium present as the salt of an excess of said ligand.
Claim 14
Dependent Claim
17 words
The method of claim 11 wherein the metal-ligand complex is used in the form of a salt.
Claim 15
Dependent Claim
14 words
The method of claim 11 wherein the metal-ligand complex is used in non-ionic form.
References Cited (Backward Citations)
GB736432A
Cited
US4176173A
Cited
US4647447A
Cited
US4478816A
Cited
US4810782A
Cited
US4822594A
Cited
US5082649A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-04-19 | 1996-10-19 | 1997-04-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-04-19 | 2000-10-19 | 2001-04-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-04-19 | 2004-10-19 | 2005-04-20 | $7700.00 | Window Closed / Lapsed |