US5246013A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Probe, system and method for detecting cartilage degeneration
Assignee: Massachusetts Institute of Technology
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Filing: 1992-01-07
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Granted: 1993-09-21
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Expires: 2012-01-07
Abstract
Abstract A surface probe is disclosed for use in detecting the degree of degeneration in mammalian tissue. The surface probe comprises in combination with each other surface probe means for applying to a surface of the mammalian tissue a force which affects an electrokinetic parameter indicative of the amount of charged specie involved in tissue degeneration and surface detection means for detecting the electrokinetic parameter at the same surface of the mammalian tissue. A method is disclosed for detecting the degree of degeneration in mammalian tissues. Further, a system for diagnosing degenerative changes in cartilage tissue is disclosed. The system discloses a waveform generator as a source of current connected with connectors for transmitting electrical current between the generator and the surface electrodes of the surface probe and a computer connected by connectors to surface electrodes and transmitting electrodes in the surface probe for controlling electromechanical input to the surface electrodes and processing electromechanical output from the transmitting electrodes.
Inventors
- 👤 Eliot H. Frank
- 👤 Evan P. Salant
- 👤 Alan J. Grodzinsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:04
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/45; A61B5/4514; A61B5/0048; A61B5/0051; A61B5/0053; A61B5/4528
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
80 words
A surface probe for use in detecting the degree of degeneration in mammalian tissue, comprising a self-contained unit having mounted thereon in combination with each other: a) surface probe means for applying to a surface of the mammalian tissue a force which affects an electrokinetic parameter indicative of the amount of charged specie involved in tissue degeneration; and b) surface detection means for detecting said electrokinetic parameter at the same surface of the mammalian tissue where said force is applied.
Claim 2
Dependent Claim
80 words
A surface probe for use in detecting the degree of degeneration in mammalian tissue, comprising a self-contained unit having mounted thereon in combination with each other: a) surface probe means for applying to a surface of the mammalian tissue a force which affects an electrokinetic parameter indicative of the amount of charged specie involved in tissue degeneration; and b) surface detection means for detecting said electrokinetic parameter at the same surface of the mammalian tissue where said force is applied.
Claim 3
Dependent Claim
38 words
A surface probe of claim 1 wherein said surface probe means for applying comprises means for applying an electrical force into said tissue and said surface detection means for detecting said electrokinetic parameter comprises a mechanical stress detector.
Claim 4
Dependent Claim
31 words
A surface probe of claim 2 wherein said surface probe means for applying has electrodes for directing an electrical force into said tissue which comprise an interdigitating grid of conductive material.
Claim 5
Dependent Claim
16 words
A surface probe of claim 3 wherein the conductive material of said electrodes comprise a metal.
Claim 6
Dependent Claim
17 words
A surface probe of claim 4 wherein the conductive material of said electrodes comprise a metal salt.
Claim 7
Dependent Claim
17 words
A surface probe of claim 5 wherein said conductive metal salt of said electrodes comprises silver chloride.
Claim 8
Dependent Claim
23 words
A surface probe of claim 5 wherein the metal salt electrode has receiving means for receiving input from a time varying current source.
Claim 9
Dependent Claim
21 words
A surface probe of claim 7 wherein the surface detection means for detecting said electrokinetic parameter comprises a piezoelectric polymeric film.
Claim 10
Dependent Claim
31 words
A surface probe of claim 8 wherein said surface detection means for detecting said electrokinetic parameter has means for transmitting a current to a computer system for data acquisition and processing.
Claim 11
Dependent Claim
32 words
A surface probe of claim 8 further comprises means for electrically isolating the surface probe means for applying said electrokinetic parameter from the surface detection probe means for detecting said electrokinetic parameters.
Claim 12
Dependent Claim
37 words
A surface probe of claim 1 wherein said surface probe means for applying comprises means for applying a mechanical stress to said tissue and said surface detection means for detecting comprises a detector for stress-generated streaming potential.
Claim 13
Independent Claim
92 words
A method for detecting the degree of degeneration in mammalian tissue, comprising: a) applying to a surface of the mammalian tissue a force which affects an electrokinetic parameter indicative of the amount of charged species involved in tissue degeneration of said mammalian tissue; b) detecting said electrokinetic parameter at the same surface of the mammalian tissue where said force is applied; and c) comparing the detected electrokinetic parameter values to a normal value for said tissue previously measured from clinically normal tissue to thereby detect the degree of degeneration in mammalian tissue.
Claim 14
Independent Claim
92 words
A method for detecting the degree of degeneration in mammalian tissue, comprising: a) applying to a surface of the mammalian tissue a force which affects an electrokinetic parameter indicative of the amount of charged species involved in tissue degeneration of said mammalian tissue; b) detecting said electrokinetic parameter at the same surface of the mammalian tissue where said force is applied; and c) comparing the detected electrokinetic parameter values to a normal value for said tissue previously measured from clinically normal tissue to thereby detect the degree of degeneration in mammalian tissue.
Claim 15
Dependent Claim
48 words
A method of claim 12 wherein the force in step (a) is applied into said tissue at varying depths or thicknesses by using electrical currents of variable temporal frequency and a variable imposed spatial wavelength by means of selectable excitation of elecrode segments of an interdigitating conductive grid.
Claim 16
Dependent Claim
33 words
A method of claim 13 wherein the force in step (a) which affects an electrokinetic parameter and said step of detecting said electrokinetic parameter occurs simultaneously with the step of applying the force.
Claim 17
Dependent Claim
19 words
A method of claim 12 wherein the force in step (a) is applied to cartilage tissue of a mammal.
Claim 18
Dependent Claim
114 words
A planar, multilayered, surface probe for diagnosing degenerative changes in cartilage tissue, comprising: a) surface electrodes with an interdigitating grid of conductive material for application of electrical current to a cartilage surface; b) a first insulating sheet with its lower surface metalized for electrical grounding and said surface electrodes bonded to the upper insulating surface of said first insulating sheet; c) a second insulating sheet bonded to the metalized side of the first insulating sheet; d) a piezoelectric polymeric film for transduction of mechanical stress to electrical current, bonded to the second insulating sheet; and e) electrodes bonded to said film for transmitting electrical current generated by the piezoelectric polymeric film to a detector.
Claim 19
Dependent Claim
114 words
A planar, multilayered, surface probe for diagnosing degenerative changes in cartilage tissue, comprising: a) surface electrodes with an interdigitating grid of conductive material for application of electrical current to a cartilage surface; b) a first insulating sheet with its lower surface metalized for electrical grounding and said surface electrodes bonded to the upper insulating surface of said first insulating sheet; c) a second insulating sheet bonded to the metalized side of the first insulating sheet; d) a piezoelectric polymeric film for transduction of mechanical stress to electrical current, bonded to the second insulating sheet; and e) electrodes bonded to said film for transmitting electrical current generated by the piezoelectric polymeric film to a detector.
Claim 20
Dependent Claim
98 words
A system for diagnosing degenerative changes in cartilage tissue, comprising: a) a surface probe of claim 16 with means for mounting said probe to the surface of the tissue; b) a waveform generator, as a source of electrical current, connected with converters for transmitting electrical current between said generator and said surface electrodes of said surface probe, to the surface electrode of said surface probe; and c) a computer connected by connectors to surface electrodes and transmitting electrodes in said surface probe for controlling electromechanical input to the surface electrodes and processing electromechanical output from the transmitting electrodes.
References Cited (Backward Citations)
US4361154A
Cited
US4754763A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-20 | 1997-03-22 | 1997-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-20 | 2001-03-22 | 2001-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-20 | 2005-03-22 | 2005-09-21 | $7700.00 | Window Closed / Lapsed |