US5298022A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Wearable artificial pancreas
Assignee: A Menarini Industrie Farmaceutiche Riunite SRL
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Filing: 1993-01-04
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Granted: 1994-03-29
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Expires: 2013-01-04
Abstract
Abstract A device for the continuous quantitative determination of glucose in the blood of a diabetic patient over a period of 24-36 hours, comprises a container for a saline solution with heparin, a microdialyzing needle inserted into a vein of a diabetic patient, a pump for injecting the solution into the microdialyzing needle, a semipermeable hollow fiber membrane located externally of the needle whereby dialysis occurs between the blood and the solution and only glucose and other substances of low molecular weight below 100,000 daltons go through the membrane and the concentration of the glucose and other substances of low molecular weight below 100,000 daltons inside the needle is proportional to that of the external side of the membrane. The needle is provided with an outgoing conduit, the conduit leads to a sensor, which comprises an enzymatic membrane coupled with a Platinum-Silver electrode. The glucose goes into the conduit, oxidation of glucose to gluconic acid and hydrogen peroxide occurs and the hydrogen peroxide is decomposed to give H 2 O and oxygen with the liberation of two electrons whereby electric current is produced and the concentration of glucose in the blood is determined by determining the amount of current produced. It is possible to vary the dilution ratio of the fluid circulating inside the microdialyzing needle by varying the pump speed so that it is possible to have a ratio of the glucose containing saline solution to the actual concentration of glucose in the blood of 1/2-1/20.
Inventors
- 👤 Luigi Bernardi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:21
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; A61B5/14525; A61B5/14528
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
241 words
A device for the continuous quantitative determination of glucose in the blood of a diabetic patient over a period of 24-36 hours, which comprises a container for a saline solution containing heparin, a microdialyzing needle inserted into a vein of said diabetic patient, pumping means for injecting said solution through said microdialyzing needle which contains a semipermeable plastic hollow fiber membrane located on its outer surface whereby dialysis occurs between the blood in the vein and said solution and only glucose and other substances of low molecular weight below 100,000 daltons go through said semipermeable fiber membrane and the concentration of said glucose and other substances of low molecular weight below 100,000 daltons reaches an equilibrium which is proportional to the actual concentration of glucose in the blood, and a glucose-containing saline solution is obtained, said microdialyzing needle being provided with an outgoing conduit, said conduit leading to a sensor, said sensor comprising a platinum silver electrode and an enzymatic membrane containing glucose oxidase, said glucose containing saline solution goes into said conduit, oxidation of glucose to gluconic acid and hydrogen peroxide occurs and said hydrogen peroxide is decomposed with the liberation of two electrons whereby electric current is produced, the concentration of glucose in the blood is determined by determining the amount of current produced, without recirculation of blood, said glucose containing saline solution contains about 1/2-1/20 of the glucose concentration in the blood and said saline solution is discarded.
Claim 2
Independent Claim
241 words
A device for the continuous quantitative determination of glucose in the blood of a diabetic patient over a period of 24-36 hours, which comprises a container for a saline solution containing heparin, a microdialyzing needle inserted into a vein of said diabetic patient, pumping means for injecting said solution through said microdialyzing needle which contains a semipermeable plastic hollow fiber membrane located on its outer surface whereby dialysis occurs between the blood in the vein and said solution and only glucose and other substances of low molecular weight below 100,000 daltons go through said semipermeable fiber membrane and the concentration of said glucose and other substances of low molecular weight below 100,000 daltons reaches an equilibrium which is proportional to the actual concentration of glucose in the blood, and a glucose-containing saline solution is obtained, said microdialyzing needle being provided with an outgoing conduit, said conduit leading to a sensor, said sensor comprising a platinum silver electrode and an enzymatic membrane containing glucose oxidase, said glucose containing saline solution goes into said conduit, oxidation of glucose to gluconic acid and hydrogen peroxide occurs and said hydrogen peroxide is decomposed with the liberation of two electrons whereby electric current is produced, the concentration of glucose in the blood is determined by determining the amount of current produced, without recirculation of blood, said glucose containing saline solution contains about 1/2-1/20 of the glucose concentration in the blood and said saline solution is discarded.
Claim 3
Independent Claim
244 words
A device for the short term continuous quantitative determination of lactate in the blood of an athlete or of a heart patient, which comprises a container for a saline solution containing heparin, a microdialyzing needle inserted into a vein of said athlete or heart patient, pumping means for injecting said solution through said microdialyzing needle which contains a semipermeable plastic hollow fiber membrane located on its outer surface whereby dialysis occurs between the blood in the vein and said solution and only lactate and other substances of low molecular weight below 100,000 daltons go through said semipermeable fiber membrane and the concentration of said lactate and other substances of low molecular weight below 100,000 daltons reaches an equilibrium which is proportional to the actual concentration of lactate in the blood, and a lactate containing saline solution is obtained, said microdialyzing needle being provided with an outgoing conduit, said conduit leading to a sensor, said sensor comprising a platinum silver electrode and an enzymatic membrane containing lactate oxidase, said lactate containing saline solution goes into said conduit, oxidation of lactate to pyruvate and hydrogen peroxide occurs and said hydrogen peroxide is decomposed with the liberation of two electrons whereby electric current is produced, and the concentration of lactate in the blood is determined by determining the amount of current produced without recirculation of blood, said lactate containing saline solution contains about 1/2-1/20 of the lactate concentration in the blood, and said saline solution is discarded.
Claim 4
Independent Claim
244 words
A device for the short term continuous quantitative determination of lactate in the blood of an athlete or of a heart patient, which comprises a container for a saline solution containing heparin, a microdialyzing needle inserted into a vein of said athlete or heart patient, pumping means for injecting said solution through said microdialyzing needle which contains a semipermeable plastic hollow fiber membrane located on its outer surface whereby dialysis occurs between the blood in the vein and said solution and only lactate and other substances of low molecular weight below 100,000 daltons go through said semipermeable fiber membrane and the concentration of said lactate and other substances of low molecular weight below 100,000 daltons reaches an equilibrium which is proportional to the actual concentration of lactate in the blood, and a lactate containing saline solution is obtained, said microdialyzing needle being provided with an outgoing conduit, said conduit leading to a sensor, said sensor comprising a platinum silver electrode and an enzymatic membrane containing lactate oxidase, said lactate containing saline solution goes into said conduit, oxidation of lactate to pyruvate and hydrogen peroxide occurs and said hydrogen peroxide is decomposed with the liberation of two electrons whereby electric current is produced, and the concentration of lactate in the blood is determined by determining the amount of current produced without recirculation of blood, said lactate containing saline solution contains about 1/2-1/20 of the lactate concentration in the blood, and said saline solution is discarded.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-28 | 1997-09-27 | 1998-03-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-28 | 2001-09-27 | 2002-03-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-28 | 2005-09-27 | 2006-03-29 | $7700.00 | Window Closed / Lapsed |