US5308771A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemical sensors
Assignee: Science Applications International Corp SAIC
•
Filing: 1992-04-13
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Granted: 1994-05-03
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Expires: 2012-04-13
Abstract
Abstract A device for detecting the presence or concentration of an analyte, a method of making the device, and a method of detecting the presence or concentration of an analyte. The invention features one or more supports, such as beads, which carry a thin film of polymer substrate. The polymer substrate has a sensing reagent and a porous matrix. The sensing reagent alters the optical properties of the polymer substrate in the presence of analyte.
Inventors
- 👤 Quan Zhou
- 👤 Mary E. Tabacco
- 👤 Bruce N. Nelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 18:59
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; G01N2021/7769; G01N2021/7783; Y; Y10; Y10T; Y10T436/00; Y10T436/17; Y10T436/173845; Y10T436/175383; Y10T436/20; Y10T436/204998; Y10T436/205831; Y10T436/21; Y10T436/214; Y10T436/216
Claims Analysis
Total Claims: 54
Claim 1
Independent Claim
136 words
A device for detecting the presence or concentration of an analyte comprising: a sensing element comprising at least one bead having an outer film layer of a polymer substrate, said polymer substrate being capable of receiving and discharging light, and said polymer substrate having a porous matrix and sensing reagent; said sensing reagent being entrapped within and chemically bound to the polymer substrate and having a first absorption spectra in the presence of analyte and a second absorption spectra in the absence of analyte; said porous matrix expanding the effective surface area of said polymer substrate for receiving analyte, said polymer substrate allowing said sensing reagent to alter the spectra of light passing through said polymer substrate in the presence of analyte; and said bead comprising a material for providing mechanical strength to the polymer substrate.
Claim 2
Independent Claim
136 words
A device for detecting the presence or concentration of an analyte comprising: a sensing element comprising at least one bead having an outer film layer of a polymer substrate, said polymer substrate being capable of receiving and discharging light, and said polymer substrate having a porous matrix and sensing reagent; said sensing reagent being entrapped within and chemically bound to the polymer substrate and having a first absorption spectra in the presence of analyte and a second absorption spectra in the absence of analyte; said porous matrix expanding the effective surface area of said polymer substrate for receiving analyte, said polymer substrate allowing said sensing reagent to alter the spectra of light passing through said polymer substrate in the presence of analyte; and said bead comprising a material for providing mechanical strength to the polymer substrate.
Claim 3
Dependent Claim
44 words
The device of claim 1 further comprising light inputting and discharging means in communication with said polymer substrate, said light inputting and discharging means being capable of directing light from a light source into said polymer substrate and receiving light from said polymer substrate.
Claim 4
Dependent Claim
29 words
The device of claim 2 wherein said light receiving and discharging means comprise a housing which housing retains said polymer substrate in communication with one or more optical fibers.
Claim 5
Dependent Claim
83 words
The device of claim 3 wherein said housing has wall means and two ends defining an interior chamber and an exterior surface, one of said ends having an optical fiber for directing light into said interior chamber, and one of said ends having an optical fiber for receiving light rom said interior chamber, said interior chamber being in communication with said exterior surface by one or more openings in said wall means, and said sensing element being substantially enclosed within said interior chamber.
Claim 6
Dependent Claim
12 words
The device of claim 1 wherein said bead is made of glass.
Claim 7
Dependent Claim
15 words
The device of claim 1 wherein said sensing element includes a plurality of said beads.
Claim 8
Dependent Claim
16 words
The device of claim 6 wherein said bead is approximately 100 to 1000 microns in diameter.
Claim 9
Dependent Claim
19 words
The device of claim 6 wherein said polymer substrate film has a thickness of up to about 200 microns.
Claim 10
Dependent Claim
20 words
The device of claim 8 wherein said polymer substrate has a pore size of about 50 angstrom to 200 angstroms.
Claim 11
Dependent Claim
46 words
The device of claim 1 wherein said sensing reagent has a first absorption spectra and a second absorption spectra in the presence or absence of one or more of the analytes selected from the group consisting of hydrogen ion, hydrazine, ethylene, ammonia, carbon monoxide and water.
Claim 12
Dependent Claim
29 words
The device of claim 1 wherein said sensing reagent is selected from the groups of sensing reagents consisting of bromophenol red, bromocresol purple, vanillin, cobalt chloride and palladious chloride.
Claim 13
Dependent Claim
16 words
The device of claim 1 wherein said sensing reagent is substantially dispersed in said polymer substrate.
Claim 14
Dependent Claim
11 words
The device of claim 1 wherein said polymer substrate is hydrophilic.
Claim 15
Dependent Claim
14 words
The device of claim 13 wherein said polymer substrate is 2-hydroxyethyl methacrylate and polyacrylamide.
Claim 16
Dependent Claim
11 words
The device of claim 1 wherein said polymer substrate is hydrophobic.
Claim 17
Dependent Claim
16 words
The device of claim 15 wherein said polymer substrate is methyl methacrylate and triethylene glycol dimethacrylate.
Claim 18
Dependent Claim
31 words
The device of claim 1 wherein said polymer substrate is expanded by the presence of a solvent during a polymerization reaction, which solvent is removed after the polymerization reaction is completed.
Claim 19
Dependent Claim
12 words
The device of claim 17 wherein said solvent is an organic solvent.
Claim 20
Dependent Claim
12 words
The device of claim 17 wherein said solvent is an inorganic solvent.
Claim 21
Independent Claim
180 words
A method of detecting the presence or concentration of an analyte comprising the following steps: a) contacting a sample potentially containing analyte with a sensing element comprising at least one bead having an outer film layer of a polymer substrate, said polymer substrate being capable of receiving and discharging light, and said polymer substrate having a porous matrix and sensing reagent; said sensing reagent being chemically bound to the polymer substrate and having a first absorption spectra in the presence of analyte and a second absorption spectra in the absence of analyte; said porous matrix expanding the effective surface area of said polymer substrate, said sensing reagent altering the spectra of light passing through said polymeric substrate in the presence of analyte; and said bead comprising a material which is capable of providing mechanical strength to the polymer substrate; and b) inputting light into said polymer substrate, said light having a spectra capable of being altered by said sensing reagent; and c) monitoring light leaving said polymer substrate for alteration indicative of the presence or absence or concentration of analyte.
Claim 22
Independent Claim
180 words
A method of detecting the presence or concentration of an analyte comprising the following steps: a) contacting a sample potentially containing analyte with a sensing element comprising at least one bead having an outer film layer of a polymer substrate, said polymer substrate being capable of receiving and discharging light, and said polymer substrate having a porous matrix and sensing reagent; said sensing reagent being chemically bound to the polymer substrate and having a first absorption spectra in the presence of analyte and a second absorption spectra in the absence of analyte; said porous matrix expanding the effective surface area of said polymer substrate, said sensing reagent altering the spectra of light passing through said polymeric substrate in the presence of analyte; and said bead comprising a material which is capable of providing mechanical strength to the polymer substrate; and b) inputting light into said polymer substrate, said light having a spectra capable of being altered by said sensing reagent; and c) monitoring light leaving said polymer substrate for alteration indicative of the presence or absence or concentration of analyte.
Claim 23
Dependent Claim
52 words
The method of claim 20 wherein said support means and polymer substrate are held in light inputting and discharging means in communication with said polymer substrate, said light inputting and discharging means being capable of directing light from a light source into said polymer substrate and receiving light leaving said polymer substrate.
Claim 24
Dependent Claim
30 words
The method of claim 21 wherein said light receiving and discharging means comprise a housing which housing retains said polymer substrate in communication with said one or more optical fibers.
Claim 25
Dependent Claim
80 words
The method of claim 22 wherein said housing has wall means and two ends defining an interior chamber and an exterior surface, one of said ends having an optical fiber for directing light into said interior chamber, and one of said ends having an optical fiber for receiving light from said interior chamber, said interior chamber in communication with said exterior surface by at least one opening in said wall means, sensing element being substantially enclosed within said interior chamber.
Claim 26
Dependent Claim
12 words
The method of claim 20 wherein said bead is made of glass.
Claim 27
Dependent Claim
15 words
The method of claim 20 wherein said sensing element includes a plurality of said beads.
Claim 28
Dependent Claim
16 words
The method of claim 25 wherein said bead is approximately 100 to 1000 microns in diameter.
Claim 29
Dependent Claim
19 words
The method of claim 25 wherein said polymer substrate film has a thickness of up to about 200 microns.
Claim 30
Dependent Claim
20 words
The method of claim 25 wherein said polymer substrate has a pore size of about 50 angstroms to 200 angstroms.
Claim 31
Dependent Claim
45 words
The method of claim 20 wherein said sensing reagent has a first absorption spectra and a second absorption spectra in the presence or absence of one or more of the analytes selected from the group consisting of hydrogen ion, ethylene, ammonia, carbon monoxide and water.
Claim 32
Dependent Claim
29 words
The method of claim 20 wherein said sensing reagent is selected from the group of sensing reagents consisting of bromophenol red, bromocresol purple, vanillin, cobalt chloride and palladious chloride.
Claim 33
Dependent Claim
11 words
The method of claim 20 wherein said polymer substrate is hydrophilic.
Claim 34
Dependent Claim
14 words
The method of claim 31 wherein said polymer substrate is 2-hydroxyethyl methacrylate and polyacrylamide.
Claim 35
Dependent Claim
10 words
The method of claim 31 wherein said solvent is inorganic.
Claim 36
Dependent Claim
11 words
The method of claim 20 wherein said polymer substrate is hydrophobic.
Claim 37
Dependent Claim
16 words
The method of claim 34 wherein said polymer substrate is methyl methacrylate and triethylene glycol dimethacrylate.
Claim 38
Dependent Claim
31 words
The method of claim 20 wherein said polymer substrate is expanded by the presence of a solvent during a polymeric reaction, which solvent is removed after the polymerization reaction is completed
Claim 39
Dependent Claim
10 words
The method of claim 36 wherein said solvent is organic.
Claim 40
Independent Claim
164 words
A method of making a device for detecting the presence or concentration of analyte comprising the following steps: a) providing a mixture of at least one monomer, sensing reagent and solvent; b) polymerizing the mixture in the presence of beads to form an outer film layer of a polymer substrate on each of the beads, the polymer substrate including a porous matrix formed by elimination of the solvent and the sensing reagent being chemically bound to the matrix; wherein said polymer substrate is capable of receiving and discharging light, said sensing reagent having a first absorption spectra in the presence of analyte and a second absorption spectra in the absence of analyte; said porous matrix expanding the effective surface area of said polymer substrate for receiving analyte, said polymer substrate allowing said sensor reagent to alter the spectra of light passing through said polymer substrate in the presence of analyte; and said bead comprising the material for providing mechanical support to the polymer substrate.
Claim 41
Independent Claim
164 words
A method of making a device for detecting the presence or concentration of analyte comprising the following steps: a) providing a mixture of at least one monomer, sensing reagent and solvent; b) polymerizing the mixture in the presence of beads to form an outer film layer of a polymer substrate on each of the beads, the polymer substrate including a porous matrix formed by elimination of the solvent and the sensing reagent being chemically bound to the matrix; wherein said polymer substrate is capable of receiving and discharging light, said sensing reagent having a first absorption spectra in the presence of analyte and a second absorption spectra in the absence of analyte; said porous matrix expanding the effective surface area of said polymer substrate for receiving analyte, said polymer substrate allowing said sensor reagent to alter the spectra of light passing through said polymer substrate in the presence of analyte; and said bead comprising the material for providing mechanical support to the polymer substrate.
Claim 42
Dependent Claim
12 words
The method of claim 38 wherein said bead is made of glass.
Claim 43
Dependent Claim
17 words
The method of claim 39 wherein said film has a thickness of up to about 200 microns.
Claim 44
Dependent Claim
16 words
The method of claim 39 wherein said bead is approximately 100 to 1000 microns in diameter.
Claim 45
Dependent Claim
45 words
The method of claim 38 wherein said sensing reagent has a first absorption spectra and a second absorption spectra in the presence or absence of one or more of the analytes selected from the group consisting of hydrogen ion, ethylene, ammonia, carbon monoxide and water.
Claim 46
Dependent Claim
29 words
The method of claim 38 wherein said sensing reagent is selected from the group of sensing reagents consisting of bromophenol red, bromocresol purple, vanillin, cobalt chloride and palladious chloride.
Claim 47
Dependent Claim
20 words
The method of claim 38 wherein said polymer substrate has a pore size of about 50 angstroms to 200 angstroms.
Claim 48
Dependent Claim
11 words
The method of claim 38 wherein said polymer substrate is hydrophilic.
Claim 49
Dependent Claim
15 words
The method of claim 45 wherein said polymer substrate is 2 hydroxyethyl methacrylate and polyacrylamide.
Claim 50
Dependent Claim
11 words
The method of claim 38 wherein said polymer substrate is hydrophobic.
Claim 51
Dependent Claim
16 words
The method of claim 47 wherein said polymer substrate is methyl methacrylate and triethylene glycol dimethacrylate.
Claim 52
Dependent Claim
10 words
The method of claim 48 wherein said solvent is organic.
Claim 53
Dependent Claim
10 words
The method of claim 48 wherein said solvent is inorganic.
Claim 54
Dependent Claim
33 words
The method of claim 38 wherein said polymer substrate is expanded by the presence of a solvent during a polymeric reaction, which solvent is removed by washing after the polymerization reaction is completed.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-05-02 | 1997-11-01 | 1998-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-05-02 | 2001-11-01 | 2002-05-03 | $3760.00 | Window Closed / Lapsed |
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