US5326552A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants
Assignee: PARTICULATE PROSPECTS CORP
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Filing: 1992-12-17
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Granted: 1994-07-05
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Expires: 2012-12-17
Abstract
Abstract The present invention is directed to a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith. The present invention is still further directed to a method for diagnostic imaging for use in medical procedures comprising administering to the body of a test subject in need of an X-ray an effective contrast producing amount of a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.
Inventors
- 👤 George C. Na
- 👤 Natarajan Rajagopalan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:56
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0476; A61K49/0485; A61K49/049; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
72 words
A composition comprised of nanoparticles containing an X-ray diagnostic compound, having a nonionic surfactant having a molecular weight of at least 4000 as a surface modifier adsorbed on the surface thereof in an amount of 1 to 75% by weight based on the total weight of the particle and a cloud point modifier associated therewith present in an amount of 0.01-20% by weight based on the total weight of the composition .
Claim 2
Dependent Claim
72 words
A composition comprised of nanoparticles containing an X-ray diagnostic compound, having a nonionic surfactant having a molecular weight of at least 4000 as a surface modifier adsorbed on the surface thereof in an amount of 1 to 75% by weight based on the total weight of the particle and a cloud point modifier associated therewith present in an amount of 0.01-20% by weight based on the total weight of the composition .
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein said X-ray diagnostic compound is ethyl 3,5-diacetoamido-2,4,6-triiodobenzoate.
Claim 4
Dependent Claim
12 words
The composition of claim 1 wherein said non-ionic surfactant is a poloxamine.
Claim 5
Dependent Claim
25 words
The composition of claim 3 wherein said poloxamine is a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine.
Claim 6
Dependent Claim
13 words
The composition of claim 1 wherein said cloud point modifier is a phospholipid.
Claim 7
Dependent Claim
12 words
The composition of claim 5 wherein said phospholipid is dimyristoyl phosphatidyl glycerol.
Claim 8
Dependent Claim
14 words
The composition of claim 1 wherein said cloud point modifier is an anionic surfactant.
Claim 9
Dependent Claim
12 words
The composition of claim 7 wherein said cloud point modifier is dioctylsulfosuccinate.
Claim 10
Dependent Claim
32 words
The composition of claim 1 wherein said cloud point modifier is selected from the group consisting of polyethylene glycol, propylene glycol, ethanol, cyclodextrin, sodium dodecyl sulfate, dioctylsulfosuccinate, cetrimide, dimyristoylphosphatidylglycerol, cardiolipin and dimyristoylphosphatidylserine.
Claim 11
Dependent Claim
11 words
The composition of claim 1 further comprising a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
43 words
A method for X-ray imaging for use in medical procedures comprising administering to the body of a test subject need of an X-ray an effective contrast producing amount of a composition of claim 1; and performing an X-ray imaging procedure on said subject.
Claim 13
Dependent Claim
33 words
A composition comprised of nanoparticles containing an X-ray diagnostic compound having a nonionic poloxamine surfactant having a molecular weight of at least about 30,000 as a surface modifier adsorbed on the surface thereof.
Claim 14
Dependent Claim
33 words
A composition comprised of nanoparticles containing an X-ray diagnostic compound having a nonionic poloxamine surfactant having a molecular weight of at least about 30,000 as a surface modifier adsorbed on the surface thereof.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-07-04 | 1998-01-03 | 1998-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-07-04 | 2002-01-03 | 2002-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-07-04 | 2006-01-03 | 2006-07-05 | $7700.00 | Window Closed / Lapsed |