US5348002A
Expired / Lapsed
US
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Method and apparatus for material analysis
Assignee: SIRRAYA Inc A CORP OF
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Filing: 1992-04-23
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Granted: 1994-09-20
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Expires: 2012-04-23
Abstract
Abstract Disclosed is a method and apparatus for determining the presence and/or concentration of chemical species which absorb electromagnetic energy, dependent to a degree upon the chemical species and the wavelength of electromagnetic energy applied to matter including said species. The absorbed electromagnetic energy generates acoustic energy which is detected and analyzed to determine the presence and/or concentration of the chemical species in the matter.
Inventors
- 👤 Richard G. Caro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 03:51
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/14551; A61B5/14552; A61B5/0093; A61B5/0095; A61B5/14532; A61B5/68; A61B5/6801; A61B5/6813; A61B5/6825; A61B5/6826; A61B5/683; A61B5/6838; G; G01; G01N; G01N29/00; G01N29/14; G01N29/22; G01N29/24; G01N29/2412; G01N29/44; G01N29/449; G01N2291/00; G01N2291/01; G01N2291/015; G01N2291/02; G01N2291/024; G01N2291/02475; G01N2291/02483; G01N2291/028; G01N2291/02809
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
108 words
The method of determining the concentration of a chemical species in condensed that scatters and absorbs electromagnetic energy comprising the steps of exciting a volume of said matter with electromagnetic energy of predetermined wavelength to cause said volume to generate acoustic energy, detecting said acoustic energy and generating a signal representative of the amplitude of the acoustic energy; developing a relationship between the amplitude of the acoustic energy generated in said condensed matter and the degree of absorption of said electromagnetic energy by said matter and chemical species; and analyzing the amplitude of said acoustic energy, making use of said relationship to determine the concentration of said species.
Claim 2
Independent Claim
108 words
The method of determining the concentration of a chemical species in condensed that scatters and absorbs electromagnetic energy comprising the steps of exciting a volume of said matter with electromagnetic energy of predetermined wavelength to cause said volume to generate acoustic energy, detecting said acoustic energy and generating a signal representative of the amplitude of the acoustic energy; developing a relationship between the amplitude of the acoustic energy generated in said condensed matter and the degree of absorption of said electromagnetic energy by said matter and chemical species; and analyzing the amplitude of said acoustic energy, making use of said relationship to determine the concentration of said species.
Claim 3
Dependent Claim
15 words
The method as in claim 1 in which the condensed matter is a biological material.
Claim 4
Independent Claim
128 words
The method of determining the concentration of multiple or single chemical species in a sample which both scatters and absorbs electromagnetic energy comprising the steps of irradiating the sample with electromagnetic energy at selected wavelengths to cause the sample to generate acoustic energy; detecting the acoustic energy and generating signals representative of the amplitude of said acoustic energy at said wavelengths; developing a relationship between the amplitude of said acoustic energy in said sample and the degree of absorption by said sample and multiple or single species for each selected wavelength; and analyzing the dependence of the amplitude of said acoustic signal on the selected wavelength of the electromagnetic energy, making use of said relationship to determine the concentration of said multiple or single species in said sample.
Claim 5
Independent Claim
128 words
The method of determining the concentration of multiple or single chemical species in a sample which both scatters and absorbs electromagnetic energy comprising the steps of irradiating the sample with electromagnetic energy at selected wavelengths to cause the sample to generate acoustic energy; detecting the acoustic energy and generating signals representative of the amplitude of said acoustic energy at said wavelengths; developing a relationship between the amplitude of said acoustic energy in said sample and the degree of absorption by said sample and multiple or single species for each selected wavelength; and analyzing the dependence of the amplitude of said acoustic signal on the selected wavelength of the electromagnetic energy, making use of said relationship to determine the concentration of said multiple or single species in said sample.
Claim 6
Dependent Claim
90 words
The method of claim 3 including the additional steps of detecting the irradiating electromagnetic energy at said selected wavelengths after it has traversed a volume of said sample and generating intensity signals representative of the intensity of said electromagnetic radiation at said wavelengths; analyzing the dependence of said intensity signals on the selected wavelengths of the electromagnetic energy to determine the concentration of said multiple or single species; and correlating said electromagnetic and acoustic analysis to enhance the accuracy of said determination of concentration of said multiple or single species.
Claim 7
Independent Claim
30 words
The method as in claims 1, 3 or 4 in which the scattering coefficient μ, of the sample and the sample thickness L are selected such that μ s L>>1.
Claim 8
Dependent Claim
16 words
The method of claim 1, 3 or 4 in which the analysis is by multivariate analysis.
Claim 9
Independent Claim
40 words
The method of claims 1, 3 or 4 in which the analysis is performed by comparison of the measured signals for the selected wavelengths with signals obtained from known or partially known mixtures of chemical species in said sample material.
Claim 10
Independent Claim
18 words
The method as in claims 1, 3 or 4 in which the chemical species is glucose in blood.
Claim 11
Independent Claim
18 words
The method as in claims 1, 3 or 4 in which the chemical species is oxygen in blood.
Claim 12
Independent Claim
15 words
The method as in claims 3 or 4 in which the sample is biological material.
Claim 13
Independent Claim
20 words
The method as in claims 1, 3, or 4 in which the analysis is made by partial least square correlation.
Claim 14
Independent Claim
124 words
The method of determining the absorption coefficient of a biological substance comprising the steps of exciting a volume of said biological substance with electromagnetic energy of predetermined wavelength to cause said volume to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of said biological substance at said wavelength; detecting said acoustic energy and generating a signal representative of the amplitude of said acoustic energy; developing a relationship between the amplitude of said acoustic energy in said biological substance and the degree of absorption of said electromagnetic energy, from said relationship and from the amplitude of the acoustic signal, determining the absorption coefficient of said biological substance at said wavelength.
Claim 15
Independent Claim
124 words
The method of determining the absorption coefficient of a biological substance comprising the steps of exciting a volume of said biological substance with electromagnetic energy of predetermined wavelength to cause said volume to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of said biological substance at said wavelength; detecting said acoustic energy and generating a signal representative of the amplitude of said acoustic energy; developing a relationship between the amplitude of said acoustic energy in said biological substance and the degree of absorption of said electromagnetic energy, from said relationship and from the amplitude of the acoustic signal, determining the absorption coefficient of said biological substance at said wavelength.
Claim 16
Independent Claim
158 words
The method of determining the concentration of a component species in an electromagnetic energy scattering medium comprising the steps of irradiating said medium with electromagnetic energy at selected wavelengths to cause said medium to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of said component and scattering medium at said wavelength; scanning the wavelength of said electromagnetic energy over a predetermined range of frequencies; measuring the intensity of said electromagnetic energy at said wavelengths and generating an intensity signal representative of the intensity at each of said wavelengths; detecting the acoustic energy at said wavelengths to provide an output signal having an amplitude representative of the amplitude of said acoustic energy at said wavelengths; and determining the concentration of said component species by comparing the electromagnetic energy signal and the acoustic amplitude signal with known signals for component species in a scattering medium.
Claim 17
Independent Claim
158 words
The method of determining the concentration of a component species in an electromagnetic energy scattering medium comprising the steps of irradiating said medium with electromagnetic energy at selected wavelengths to cause said medium to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of said component and scattering medium at said wavelength; scanning the wavelength of said electromagnetic energy over a predetermined range of frequencies; measuring the intensity of said electromagnetic energy at said wavelengths and generating an intensity signal representative of the intensity at each of said wavelengths; detecting the acoustic energy at said wavelengths to provide an output signal having an amplitude representative of the amplitude of said acoustic energy at said wavelengths; and determining the concentration of said component species by comparing the electromagnetic energy signal and the acoustic amplitude signal with known signals for component species in a scattering medium.
Claim 18
Dependent Claim
53 words
The method as in claim 13 in which the steps of irradiating, scanning, measuring and detecting are repeated a predetermined number of times and the electromagnetic energy intensity signals and the acoustic amplitude signals are stored and then averaged and the averaged signals are then used to determined the concentration of said species.
Claim 19
Independent Claim
151 words
The method of determining the concentration of a component in a biological material, said method comprising the steps of exciting a volume of said material with electromagnetic energy to cause a finite volume of said material to generate acoustic energy whose amplitude is dependent upon the intensity and wavelength of said electromagnetic energy and the absorption coefficient of said component at said wavelength; detecting said generated acoustic energy and generating a representative acoustic signal; developing a relationship between the amplitude of said acoustic energy in said biological material and the degree of absorption of said electromagnetic energy by said biological material and said component; determining by analysis from the intensity of the electromagnetic energy and the amplitude of the acoustic signal the absorption coefficient at said wavelength; and comparing said absorption at said wavelength with known absorption coefficients for various concentrations of said component to determine the concentration of said component.
Claim 20
Independent Claim
151 words
The method of determining the concentration of a component in a biological material, said method comprising the steps of exciting a volume of said material with electromagnetic energy to cause a finite volume of said material to generate acoustic energy whose amplitude is dependent upon the intensity and wavelength of said electromagnetic energy and the absorption coefficient of said component at said wavelength; detecting said generated acoustic energy and generating a representative acoustic signal; developing a relationship between the amplitude of said acoustic energy in said biological material and the degree of absorption of said electromagnetic energy by said biological material and said component; determining by analysis from the intensity of the electromagnetic energy and the amplitude of the acoustic signal the absorption coefficient at said wavelength; and comparing said absorption at said wavelength with known absorption coefficients for various concentrations of said component to determine the concentration of said component.
Claim 21
Independent Claim
162 words
The method of determining the concentration of a component chemical species in an electromagnetic energy scattering medium which comprises the steps of exciting a volume of said medium with electromagnetic energy at a predetermined wavelength to cause said medium to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of said component species at said wavelength; detecting said acoustic energy and generating a signal representative of the amplitude of the acoustic energy; developing a relationship between the amplitude of said acoustic energy in said scattering medium and the degree of absorption of said electromagnetic energy by said medium and said chemical species; determining from the intensity of said electromagnetic energy and the amplitude of the acoustic signal the absorption coefficient at said wavelength; and comparing said absorption coefficient at said wavelength with known absorption coefficients for said component at various concentrations to determine the concentration of said component.
Claim 22
Independent Claim
162 words
The method of determining the concentration of a component chemical species in an electromagnetic energy scattering medium which comprises the steps of exciting a volume of said medium with electromagnetic energy at a predetermined wavelength to cause said medium to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of said component species at said wavelength; detecting said acoustic energy and generating a signal representative of the amplitude of the acoustic energy; developing a relationship between the amplitude of said acoustic energy in said scattering medium and the degree of absorption of said electromagnetic energy by said medium and said chemical species; determining from the intensity of said electromagnetic energy and the amplitude of the acoustic signal the absorption coefficient at said wavelength; and comparing said absorption coefficient at said wavelength with known absorption coefficients for said component at various concentrations to determine the concentration of said component.
Claim 23
Dependent Claim
53 words
The method of claim 16 which includes additionally the step of identifying the material composition which comprises the additional step of comparing said absorption coefficient at said wavelength with known absorption coefficients of various components or various concentrations to determine not only the concentration of said component but also to identify the components.
Claim 24
Dependent Claim
27 words
The method as in claim 12, 13, 14, 15, or 16 in which the acoustic energy is gated to detect acoustic signals generated at a selected volume.
Claim 25
Independent Claim
13 words
The method as in claims 14 or 16 wherein the component is oxygen.
Claim 26
Independent Claim
197 words
The method of determining the concentration of chemical species in an electromagnetic energy scattering medium which comprises the steps of irradiating said material with electromagnetic energy to cause said medium to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of aid species at said wavelength; scanning the wavelength of said electromagnetic energy over a predetermined band of wavelengths; measuring the intensity of said electromagnetic energy at said scanned wavelengths and generating an intensity signal representative of the intensity at each of said scanned wavelengths; detecting the acoustic energy at said wavelengths to provide an output signal having an amplitude representative of said acoustic energy at said wavelengths; developing a relationship between the amplitude of said acoustic energy in said medium and the degree of absorption in said medium for each of said scanned wavelengths; determining from the electromagnetic energy signal and the acoustic energy signal the absorption coefficient of said species and scattering medium at said wavelengths; and comparing said absorption coefficients at said wavelengths with known absorption coefficients for various concentrations of said species to determine the concentrations of said species.
Claim 27
Independent Claim
197 words
The method of determining the concentration of chemical species in an electromagnetic energy scattering medium which comprises the steps of irradiating said material with electromagnetic energy to cause said medium to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of aid species at said wavelength; scanning the wavelength of said electromagnetic energy over a predetermined band of wavelengths; measuring the intensity of said electromagnetic energy at said scanned wavelengths and generating an intensity signal representative of the intensity at each of said scanned wavelengths; detecting the acoustic energy at said wavelengths to provide an output signal having an amplitude representative of said acoustic energy at said wavelengths; developing a relationship between the amplitude of said acoustic energy in said medium and the degree of absorption in said medium for each of said scanned wavelengths; determining from the electromagnetic energy signal and the acoustic energy signal the absorption coefficient of said species and scattering medium at said wavelengths; and comparing said absorption coefficients at said wavelengths with known absorption coefficients for various concentrations of said species to determine the concentrations of said species.
Claim 28
Dependent Claim
55 words
The method as in claim 20 which includes additionally the step of identifying the material composition which comprises the additional step of comparing said absorption coefficients at said scanned wavelengths with known absorption coefficients of various components or various concentrations to determine not only the concentration of said components but also to identify the components.
Claim 29
Independent Claim
20 words
The method as in claims 13, 14, 15, 16, 20 or 17 in which the component is within biological tissue.
Claim 30
Dependent Claim
20 words
The method as in claim 13, 14, 15, 16, 20, or 17 in which the component is in vitro material.
Claim 31
Independent Claim
54 words
The method as in claims 12, 13, 14, 15, 16, 20 or 17 including the additional step of detecting electromagnetic energy which is transmitted through the material to generate a transmitted radiation signal and comparing the intensity of the transmitted signal to the intensity of the irradiation signal to determine an optical absorption coefficient.
Claim 32
Independent Claim
15 words
The method as in claims 13, 16 or 17 wherein the component is blood glucose.
Claim 33
Independent Claim
121 words
The apparatus for determining the concentration of species in a biological substance comprising electromechanical means for exciting a volume of said material with electromagnetic energy to cause a finite volume of said material to generate acoustic energy whose amplitude is dependent upon the intensity and wavelength of said electromagnetic energy and the absorption coefficient of said species; transducer means for detecting said generated acoustic energy and generating a representative acoustic signal; processing means for developing a relationship between the amplitude of said acoustic energy in said biological substance and the degree of absorption of said electromagnetic energy by said biological substance; and processing means for receiving said acoustic signal, making use of the relationship and determining the concentration of said species.
Claim 34
Independent Claim
121 words
The apparatus for determining the concentration of species in a biological substance comprising electromechanical means for exciting a volume of said material with electromagnetic energy to cause a finite volume of said material to generate acoustic energy whose amplitude is dependent upon the intensity and wavelength of said electromagnetic energy and the absorption coefficient of said species; transducer means for detecting said generated acoustic energy and generating a representative acoustic signal; processing means for developing a relationship between the amplitude of said acoustic energy in said biological substance and the degree of absorption of said electromagnetic energy by said biological substance; and processing means for receiving said acoustic signal, making use of the relationship and determining the concentration of said species.
Claim 35
Dependent Claim
157 words
Apparatus for determining the concentration of a component in an electromagnetic energy scattering medium which comprises means for irradiating said material with electromagnetic energy at selected wavelengths to cause said medium to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of said component and scattering medium at said wavelength; means for scanning the selected wavelengths of said electromagnetic energy over a predetermined band; means for detecting the acoustic energy at said wavelengths and providing an output signal having an amplitude representative of said acoustic energy at said wavelengths; means for determining from the acoustic amplitude signal and the intensity of said electromagnetic energy the absorption coefficient of said component and scattering medium at said wavelengths; and means for comparing said absorption coefficients at said wavelengths with known absorption coefficients for various concentrations of said components to determine the concentration of said components.
Claim 36
Dependent Claim
157 words
Apparatus for determining the concentration of a component in an electromagnetic energy scattering medium which comprises means for irradiating said material with electromagnetic energy at selected wavelengths to cause said medium to generate acoustic energy within said medium whose amplitude is dependent upon the wavelength and intensity of said electromagnetic energy and the absorption coefficient of said component and scattering medium at said wavelength; means for scanning the selected wavelengths of said electromagnetic energy over a predetermined band; means for detecting the acoustic energy at said wavelengths and providing an output signal having an amplitude representative of said acoustic energy at said wavelengths; means for determining from the acoustic amplitude signal and the intensity of said electromagnetic energy the absorption coefficient of said component and scattering medium at said wavelengths; and means for comparing said absorption coefficients at said wavelengths with known absorption coefficients for various concentrations of said components to determine the concentration of said components.
Claim 37
Dependent Claim
32 words
The apparatus as in claim 26 or 27 in which means are provided for storing the acoustic amplitude signals and averaging said signals over a plurality of scans before determining the concentration.
Claim 38
Dependent Claim
28 words
The apparatus as in claim 26 or 27 including gating means to gate the acoustic signal to detect acoustic signals generated at a selected volume within the sample.
Claim 39
Dependent Claim
14 words
The apparatus as in claim 27 in which the component is within biological tissue.
Claim 40
Dependent Claim
14 words
The apparatus as in claim 27 in which the component is in in-vitro material.
References Cited (Backward Citations)
US3948345A
Cited
US4223680A
Cited
US4281645A
Cited
US4303343A
Cited
US4621643A
Cited
EP0160768B1
Cited
US4655225A
Cited
US5012809A
Cited
US5028787A
Cited
US4975581A
Cited
US5054487A
Cited
US5077476A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-19 | 1998-03-21 | 1998-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-19 | 2002-03-21 | 2002-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-19 | 2006-03-21 | 2006-09-20 | $7700.00 | Window Closed / Lapsed |